Xarelto Fluid Retention

Germangirl Says:

I had to take Xarelto due to two sinus venous thrombosis in my head. 8 weeks of heparin injections showed no side effects. But with the first day of taking Xarelto my body reacted by retaining water. Within the first three weeks I gained 24.46 lb hill exercising 5 times a week and eating as I always did. After retaining more and more water I stopped taking it after three months. I started with a weight of 120 lb at a height of 5''8 and now I weigh 157 lb. I have to ad that I started taking it in the middle of March and stopped taking it at the end of June. I was not able to loose any water/weight. I eat less than I always did before even while I exercise. All doctors couldn't find the one thing that changed through Xarelto. Has anybody ever experienced something like this while taking Xarelto??

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Verwon Says:

Hello, Germangirl! How are you doing? Very sorry about the problem that you ran into.

Did your doctor have you try a diuretic? It's a medication they can prescribe to help remove the excess fluid from your body.

As to the Xarelto, if you scroll down the page for it on this site, you'll see that most of the posts regarding it are due to odd side effects…


So, you're not the only person that had a very bad experience with it.

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Germangirl Says:

Hello Verwon
Thanks for your answer.
Yes we did try all diuretic that are available on the market right now. They helped a little bit on the first two days and after these two days all the water just came back. I've been sent to all different kind of doctors and they all tell me the same that they've never seen something like this before and that they have absolutely no clue how this could happen and how they could treat it. We had some experimenting me taking Metphormin, but it changed nothing.
The water does not concentrate on one specific area of the body but rather the whole body incl. fingers, toes, face, etc. And it shifts. After exercising, the water flowed down from my face and shoulders to my stomach and after an hour it just comes back up. Really creapy!

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Dee Says:

That is so creepy . I've been so bloated 6 lbs. since being on xarelto and I've gained

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Germangirl Says:

For how long have you been on Xarelto now?

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caveman Says:

Yes I have experienced the same problem with bloating and weight gain. I was on Xarelto for 6 months. Immediately when I started with the drug I started to feel bloated in my abdomen. My weight continued to rise until it was so uncomfortable that I stopped taking it. Doctors could not tell me why this was happening.
I was gaining weight despite fasting 2 days a week. I have been off the drug for 6 months now but I still feel bloated and my abdomen is still distended. This drug has clearly done something to our systems that is causing this to happen. I pray the damage is not permanent.

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Germangirl Says:

Were you able to lose any weight now?
Because I am off for 1 ½ years and nothing has changed!

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caveman Says:

I am currently on a extended water fast to try and help this condition. I have lost considerable weigh (down 20lbs), but my abdomen is still distended and I still feel bloated. It cannot be fat - it must be water retention.
I have another 10 days to go - I will let you know if anything changes.

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NomoreDVTs Says:

I'm glad to see I'm not the only one with weight gain and bloating on Xarelto. I'm 47 and was on it for six months. Although I gained only 4-5 pounds during that time, it was all concentrated in the stomach/abdomen. I've been off the drug for a month now and feel like I'm carrying a spongy spare tire - despite my best efforts, the bloat around my middle will not go away. Diuretics don't seem to be the answer. If anyone has other suggestions . . . ?

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dorie Says:

Try taking a probiotic. It helped with the bloating for me.

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Fladoc Says:

I'm a cardiologist and have had three patients with swelling. Drug representitive said no reported cases. I switched them to traditional Coumadin with low dose diuretic and gone in five days. I think xarelto causes swelling.

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Janine Says:

I am a 52 year old woman on Xarelto for about a month. I had open-heart surgery almost four months ago for a birth defect and then an ablation a five weeks ago for an atrial flutter. I resumed exercise about three weeks ago.
I have gained 8 lbs in a month, despite eating an extremely healthy diet and exercising 5 days a week. I have water weight in my abdomen and I had a tummy-tuck four years ago!! It was a relief to find this discussion because I was exasperated—examining my daily habits—wondering why all of a sudden I couldn't control my weight.
Well, I’m back to the doctor on Monday and our discussion will begin with me getting off this medication. Then I’m doing a cleanse to get it out of my system. It concerns me greatly that even after others have stopped taking the medication, the symptoms persist. I hope this is not the case for all.

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caveman Says:

Others have had no success with diuretics. Was yours successful? What did you use?

I have researched these Factor Xa Inhibitors (Xarelto & Elliquis). These drugs are highly protein bound in the blood and are not easily removed or filtered.
Could this protein binding be causing our systems to treat it as a protein deficiency which causes fluid/water retention?

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Mo Says:

My husband has been on this drug for six months with the exact same symptoms. He gained 30 pounds within days! He has pain and swelling in his legs, feet, and hands. I have read all these reviews and it sounds like most still have the distended abdomen etc.My husband is still on this drug but demanding off of it. Has your problems resolved yet and what medication If any did you use to replace it?

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Bella824 Says:

Hi Everyone. I'm 26yrs old, I was diagnosed with Pulmonary Embolism (Right Lung) I'm on Xarelto for 2weeks now and I must say I have gained 4lbs! I'm experiencing bloating, constipation, super tired, and my legs and feet feels fat but not visually. I asked my MD and he told me to eat FiberOne for constipation and bloating and it helps but it doesn't seem my stomach is going down. I'm hoping (like the rest of you of here) this is not permanent!! Besides the fact I have this problem trying to cure it, I got weight gain and all this gastro problem. Ugh! Horrible problem!!

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Germangirl Says:

I am now on a diuretic again which is called: Dytide H. I also got support tights and the combination helped. I've already lost 5 kg and you can see that water is gone from my body. At the moment, I am fasting and hope that some water will stay away. I think my body is finally recovering and finds the strength again to let the water go. I hope it continues like this.

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Mari Says:

I switched from Coumadin to Xarelto after taking coumadin for 7 years (for a protein S deficiency) and generally being sick of it. To my surprise I started to swell almost right away and in about 6 months I gained 20 pounds. I went from 119 lbs to 138.8 lbs (and let me tell you that when you're 5'1 it shows) for no reason even if I ate better and watched my portions. To give a concrete exemple, in the space of two days while barely eating anything aside from healthy meals I gained 2 1/2 pounds

I'm a healthy 25 years old and now I'm stuck with that weight gain. What is weird is that it isn't exactly fat, I don't fit in some of my pants anymore and my breats are bigger/swollen, but then again I don't have love handles, it is very weird.

I've been off Xarelto for a almost a week now, going back to Coumadin, and I'm not losing weight. The first couple of days I peed A LOT and lost about 3 pounds of liquid but it stopped after that and my weight is not fluctuating anymore even though I eat even less than I did while on Xarelto.

Did anybody manage to lose the weight after they stopped taking Xarelto and could you explain how?

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Mo Says:

My husband is now off Xarelto for two weeks and still on Lasix. He has lost 7 of the 30 pounds he gained while on this drug for 6 months. He still has swelling in his left foot and sparadically has bouts of severe pain in those areas. His abdomen isn't quite as swollen. I wish we knew how long it takes or what to do to help alleviate these problems.

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IsaGinny Says:

Yes I have gained over 14 LBS since being on Xarelto. This is my last month on it, supposedly. Started September 1st for huge DVT in left thigh. I also have tingling in my right calf, that I have seen as a side effect but weight gain is not on there. I hope it is fluid retention and can't wait to get off of it so I can start my detox/cleanse again! Glad to see I am not alone! Thanks for this blog.

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randy26933 Says:

I see I'm not the only one who thinks Xarelto caused weight gain. I am up 25lbs. I work out for an hour per day (Aerobic, weights, stretching) six days per week.

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Stoevno1 Says:

I'm 27 years old, discovered DVT in left leg just after cristmas. Started Xarelto in the begining of the year which makes it 5 and a half months. I started swelling in the ankles about 2 weeks ago and slowly started growing into the calf of right leg, stomach and face. I feel like my stomach is going to explode. I only gained 5kg on top of my 64, but I have to say I've never seen my ankles and stomach so big! After reading these posts I will have to speak to my doctor and ask for a change. I will keep u updated.

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