Rxp 500 White Round Pill And M 500 Round White Pill

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donna Says:


Are there any differences between the RXP 500 and the M 500 Metformin pills besides one is bigger than the other?


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David Says:

Hi Donna,

From what I could gather, both medications contain 500mgs of Metformin.

The only noticeable differences in my findings are found within the list of inactive ingredients.

The M 500 Metformin pills contain: Hydroxypropyl methylcellulose, hydroxypropyl cellulose type LF, magnesium stearate, methylcellulose, polyethylene glycol, and titanium dioxide.

The RXP 500 Metformin pills contain: Microcrystalline cellulose, sodium starch glycolate, polyvinylpyrrolidone, colloidal anhydrous silica, and magnesium stearate; film coating: lactose monohydrate, methylhydroxypropyl cellulose, titanium oxide, and polyethylene glycol.

For your own reference, the DIN (Drug Identification Number) for RXP 500 is 02385341 and the DIN # for M 500 is 02167786.

I hope this helps!

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Joe Says:

Is rxp 500 metformin the same as m500? Are the dosage and effects the same between one another?

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Anie Says:
via mobile

Re: David (# 1)

There happens to be two different metformin pills with M 500 written on it. The first also has APO written on it. DIN is 02167786. The second is blank on the other side. I can't find a picture of it nor the DIN anywhere.

This last pill and the rxp 500 have both been passed to me as Sandoz's metformin. I'm trying to find the truth because I react with severe pain to some of the generic forms of metformin.

Any clue about what is the M 500 with a blank side and which pill really is from Sandoz?

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David Says:

Re: Anie (# 3)

Hi Anie,

After digging deeper into this investigation, I do see your dilemma. Both Sandoz and Apotex (Canada) are claiming that the M 500 tablet is their own version of Metformin 500mg.

Canada's DIN # database for "02167786", depicts the "M 500" (APO-METFORMIN) tablet as being a product of APOTEX INC. (hence the 'APO'). Apotex's version of "M 500" reportedly contains the following set of inactive ingredients: hydroxypropyl methylcellulose, hydroxypropyl cellulose type LF, magnesium stearate, methylcellulose, polyethylene glycol, and titanium dioxide.

Sandoz's version of "M 500" with a DIN # of "02246820" is also said to be the same thing, without the APO in front, but has the following (different) set of inactive ingredients: povidone K 90, magnesium stearate; film-coating: hypromellose, titanium dioxide (E 171), and macrogol 4000.

Lastly, the DIN # 02385341 is associated with Metformin HCL 500mg made by a company called Sivem, out of Canada. They describe their pill as a white round biconvex, film-coated tablet debossed on one side with "RXP" on top of "500" and scored on the other side.

I hope this helps clear up any confusion!

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