Off-label Use For Treatment Resitant Depression

1 Reply Updated



Conversation Starter

cujo1234 Says:


Clinical trials were looking at the use of opiod agonists as off label anti-depressants. Since they block the release of glutimate without the more addictive opiate side effects. Also, releases more dopamine? Ketamine also being studied as well as anti-inflammatory drugs in combination with opioid agonists? I am probably mistating the complex bio-chemistry involved, but bottom line it seems like anti-depressant meds are all moving toward reducing inflammation by reducing glutamate release, (or is it the other way around) from the spinal column by binding opioid agonists to the pain receptors. Thereby also increasing dopamine release. I know several experimental drugs were in the pipeline but some fizzled out. Any ideas as to truly "new" anti-depressants for treatment resistant major depressive disorder? Bupronorphine hydrochloride was also mentioned frequently.



Showing Replies 1 - 1 of 1 RSS Feed


Page of 1     Sorted By:
1
David Says:

RE: "Any ideas as to truly "new" anti-depressants for treatment-resistant major depressive disorder?"

In my opinion, the idea of something being "treatment-resistant" is clinically biased for each individual's unique case of depression (or whatever condition it is that ails them). That said, to each their own and what works well for some people may not work for others. I think if we were able to come up with a long list of things we've all tried for depression, perhaps others can use it as a template for working with their doctor or in some cases self-medicate (responsibly) with alternative non-pharmaceutical options.

I do believe that opioids, when administered responsibly, can help alleviate depression - especially if it stems from pain or other related bodily discomforts. However, in today's opioid climate, this is but a dream and I feel that Kratom is a wonderful alternative.

REPLYSHAREREPORT
Was this helpful?     0     0  


Viewing page 1 of 1     Reply


More Discussions:

treatment centers for depression that take medicare
March 15 looking for a center greater Los Angeles area or throughout the country that is not acute facility but similar ... 1 reply
Nuvigil for treatment resistant depression
Nuvigil (armodafinil) saved my life. I've had treatment resistant major depression for over 20 years. Tried so many ... 31 replies
medication an treatment for depression and graves disease
If someone is being treated with fluvoxamine and are then diagnosed with graves disease could the fluvoxamine also be tr... 2 replies
Buprenorphine for Treatment Resistant Depression
Has anyone any experience taking this medication and has it helped for your Depression? I realize this is not yet consid... 41 replies
san diego treatment centers for depression
looking for a center in Southern California that takes Medicare for treatment of bipolar and depression ## Hello, John! ... 2 replies
Depression related treatment
Hi my dad was told he is suffering from depression with onset of Alzheimer's .. He was prescribed medicine as follow...
Treatment resistant depression
For 40+ years I have battled bipolar illness.. been through all meds, many ect, rTMS. and clearly dealing with trd... Ho... 4 replies
savella used for depression
Has any one been prescribed savella for depression only? I would like to know how it has worked for you and if you find ... 4 replies
Arimidex used for growth treatment in adolesence
this drug has recently been prescribed to aid in my adolesence growth. he is below the average height for a 12 year old ... 4 replies
Men use Althea pills for Acne Treatment only
Is it okay if I use Althea Pills eventhough im 17 years old and im a boy, just to treat my pimples? is there a side effe... 6 replies


Post a Reply

No registration needed.
Simply fill out the form below.

 *

 *


 Optional, stays hidden.
Get notified when a reply is posted here.




4) Text Verification: *
Prevents SPAM.

Click here to show the question



This form will be submitted securely


TRUSTe

Discussion Thread Guidelines: Any participation in the discussion threads signifies your agreement with the Terms of Use and Privacy Policy. (1) Act civilized and be respectful towards others. No profanity, vulgarity or lewd / suggestive content is allowed. (2) Posts encouraging, facilitating, or seeking advice about the abuse of medications or other substances are prohibited. (3) Personal contact information (such as telephone numbers, email addresses, etc) is not allowed to appear on our discussion threads. (4) We do not allow our forums to be used for buying, selling, trading, or for the promotion of a product or service. (5) Posting external links to other web sites is not allowed without our prior approval. (6) We reserve the right to edit or remove content which we find objectionable to the community at our sole discretion.


Note: All times displayed are GMT - 7.

This information has been independently compiled and is for informational purposes only. It is not intended to be a substitute for medical advice from a qualified healthcare professional; nor is it intended to diagnose, treat, cure or prevent any disease. For more details please see the Medical Disclaimer. This page was last updated on 28 February 2018.

We are committed to your privacy.

Copyright © 2005-2019 All Rights Reserved. MedsChat® is a registered trademark of Limelight Innovations L.L.C. 9888 W Belleview Ave #5000, Denver, CO, 80123, USA