Nimesulide Solubility

The lipophilicity and solubility profile of nimesulide was investigated over a broad pH range. Lipophilicity was assessed by direct partitioning experiments in the octanol-water system using the shake flask method, as well as by reversed-phase HPLC using methanol as organic modifier with or without addition of n-octanol. In the latter case the extrapolated retention factors logk(w) were considered as lipophilicity indices. The presence of n-octanol in the mobile phase proved to be a crucial factor for the establishment of a logk(w)/pH profile very similar to the logD/pH profile of nimesulide. Solubility was determined by the shake flask method using saturated buffer solutions. Both lipophilicity and solubility--pH profiles of nimesulide showed deviations from the theoretically expected behavior as dictated by the Henderson-Hasselbach equation and the usually recorded difference of 4 log units between the corresponding values of the neutral and ionized species in the case of a weak acid. As a consequence the lipophilicity and solubility profiles were found not to be mirror images of each other. However, the pK(a) value of nimesulide could be accurately calculated using part of both lipophilicity and solubility profiles since deviations affected mostly the values at increased ionization.

REPLY

REPORT

The usual dose is 100mg twice a day.
For Children 5mg/kg of body weight in 2 or 3 divided doses.
Nimesulide dose should be taken by prescription of physician and doctor which will help to take proper dose for good result.

REPLY

Was this helpful? 1

This my person experience with nimesulide drug:- usually i suppose to work for night shift and every one know body pain is common pain for such person. i used to take nimesulide tablet for pain relief. I am using this drug from last 3 years with recommended dose, up til now i din't experience any side effects.

REPLY

Was this helpful? 1

Nimesulide And Paracetamol a combination drug brand name Sumo...is this drug safe for prolong usage....as my mom (46 yea...

29 REPLIES

nimesulide can have during 1st trimester of pregancy ## No, the FDA, doctors and various scientists that have tested it ...

4 REPLIES

I am having severe back pain travelling to abdomen. Tried several pain killers like Diclofenac and HIfenac-D, Nicoxia MR...

3 REPLIES

Dear Sir/Madam, My wife is in 8th month of her pregnancy. Wifes age is 27. She is suffering from cold. Due to acute ear ...

2 REPLIES

between the two, which one is more harmful? ## Hello, Praly! How are you? There's really no way to say, there are ri...

2 REPLIES

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea an...

2 REPLIES

I have a arthritis a long time. Now I live in Canada. Before I used nise-nimesulide. I couldn't find a tablets in Ca...

2 REPLIES

I consumed 60 ml of rum in the night before I had a fever. I took a tab of nimesulide 100 mg after not more than 5 hours...

1 REPLY

Hello... I have taken one nimesulide tablet in combination with diclofenac at my 20 th day of pregnancy... Will it cause...

1 REPLY

I am a 43 year old male and I have been prescribed Nimesulide tablets for fever and bodyache. Tried searching for more i...

1 REPLY