Manufacturers Hydrocodone Acetaminophen 10 325

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Perry Says:


I was taking the Mallinckrodt hydrocodone-acetaminaphen 10-325. They were doing the job. My pharmacy ran out and was using Caraco hydrocodone-acetaminaphen 10-325. They were next to worthless for relief. What's the deal do you think?



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David Says:

Hi Perry,

Usually when you switch to another manufacturer's version of the same drug, the primary differences can be found in the list of "inactive" ingredients (which I personally don't believe are actually "inactive" as they say). To my understanding the various binders/fillers may account for how well you metabolize/absorb each active ingredient.

Mallinckrodt's M367 (10/325) tablets reportedly contain the following set of inactive ingredients: crospovidone + magnesium stearate + microcrystalline cellulose + povidone + corn starch + silicon dioxide + stearic acid

Maybe if you were to compare this list with Caraco's tablet, there might be some discrepancies worth noting in order to determine why one works differently than the other.

I hope this helps!

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