Levo-dromoran (Thread 248610)

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endorphin Says:

Potent narcotic analgesic. C(II): 2 mg tablet and 2 mg, discontinued

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David Says:

Hi endorphin,

I'm not finding any specific details on the discontinuation of Levo-Dromoran (levorphanol tartrate).

Do you know whether or not this only pertains to a certain dosage or brand of the medication? It's quite possible that one of the manufacturers stopped making a particular tablet. Whereas another company could've resumed production.

From what I could gather, Levo-Dromoran 2mg tablets are still currently manufactured for: Valeant Pharmaceuticals International, out of Costa Mesa, CA.

Ref: dailymed.nlm.nih.gov/dailymed/lookup.cfmsetid=a6120c36

Any thoughts on this?

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Jenna Says:

Hello,

I just thought I'd provide some additional information for Levo-Dromoran...

Based on my research, Levo-Dromoran contains the active ingredient levorphanol tartrate and is indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.

Levo-Dromoran is a potent synthetic opioid similar to morphine in its actions. Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain. Onset of analgesia and peak analgesic effect following administration of levorphanol are similar to morphine when administered at equianalgesic doses.

Side effects:

The following adverse events have been reported with the use of Levo-Dromoran:

Body as a Whole: abdominal pain, dry mouth, sweating
Cardiovascular System: cardiac arrest, shock, hypotension, arrhythmias including bradycardia and tachycardia, palpitations, extra-systoles
Digestive System: nausea, vomiting, dyspepsia, biliary tract spasm
Nervous System: coma, suicide attempt, convulsions, depression, dizziness, confusion, lethargy, abnormal dreams, abnormal thinking, nervousness, drug withdrawal, hypokinesia, dyskinesia, hyperkinesia, CNS stimulation, personality disorder, amnesia, insomnia
Respiratory System: apnea, cyanosis, hypoventilation
Skin & Appendages: pruritus, urticaria, rash, injection site reaction
Special Senses: abnormal vision, pupillary disorder, diplopia
Urogenital System: kidney failure, urinary retention, difficulty urinating

Levo-Dromoran, like morphine, may be expected to produce serious or potentially fatal respiratory depression if given in an excessive dose, too frequently, or if given in full dosage to compromised or vulnerable patients. This is because the doses required to produce analgesia in the general clinical population may cause serious respiratory depression in vulnerable patients. Safe usage of this potent opioid requires that the dose and dosage interval be individualized to each patient based on the severity of the pain, weight, age, diagnosis and physical status of the patient, and the kind and dose of concurrently administered medication.

Information referenced from: dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a6120c36-30b8-491e-8555-29a60d6f9f5b

I hope this info helps!

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