Injury-induced Partial Complex Seizures During Sleep, Keppr

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Laurie Says:

I am now a healthy 60 year old woman and I fell and hit my head on the farm 25 years ago. Since then I have suffered from partial complex seizures that occur during sleep (not every night). I am currently taking 3000 mg of divalproex and 1000 of carbamazapine daily however my seizures are still uncontrolled and appear to be happening more often. Now my neurologist wants to place me on Keppra but I'm afraid that as a result, I might have unexpected seizures that are either stronger or that occur during the day; I haven't had a daytime seizure or a grand mal sort of seizure in years and don't want those again. I want to be assured the Keppra won't induce those and I hope you can provide me with your insight.

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Verwon Says:

Unfortunately, there is no way to guarantee that it won't. There is always a risk of experiencing side effects and issues from any medication, even over the counter products. Keppra can also cause personality change, and the FDA warns about that. My husband had to stop taking it for that reason, it just made him feel angry, all the time, so he had to switch to a different medication to control his focal point seizures. Other side effects are listed as possibly including nausea, dizziness, headache, and weight changes.

The only thing you can do is try it and see how it works for you. What times of day do you take your current medications?

If you are experiencing seizures due to the change that occur in your brain, when you sleep, you might need something stronger, at night, before bed.

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Laurie Says:

Re: Verwon (# 1)
Thank you so much for your information and opinion; they are very helpful. As my seizures are specifically during sleep I will alter the morning/bedtime ratios of my medicines so that my night dosages are larger. It will be wonderful if that solves or at least minimizes my seizure problem. If that's not the case I shall perhaps consider the Keppra.

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Laurie Says:

Re: Laurie (# 2)

Hi again and just some information regarding changing the amount of my current medication (Carbamanzapine and Divalproex (sp)) that I take before bedtime as opposed to switching to Keppra. What great advice; thus far that is working and for at least 15 nights I have been seizure-free! Thank you for your wonderful advice!

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