Ic Oxycodone Apap 5 325

How long does oxycodone 5/325 or hydracodone 5/500 stay in urine for testing?Doctor said I wasn't taking my pain meds cause it didn't show up in urine test, but I am.

REPLY

REPORT

If you're taking them consistently as prescribed, then they should never be out of your system.

How often do you take them?

REPLY

Was this helpful? 0

check craigmedical can be out of your system in 1 hour to 3 days know it for a fact.

REPLY

Was this helpful? 0

This just happened to me last week. I take my prescribed medication EVERY DAY just like Im supposed to. Without them I am in such serious pain I cannot even move and will be in Severe and Constant unbarable pain. So i DEFINITELY take my meds. Last week i went in to the dr and was told i was being discharged bc my medication didnt show up in my urine screening! I do NOT know how this is possible bc I took them every day and I even took two THAT SAME DAY before my appointment! Im also prescribed adderall from another dr and my pm doc knows this. It is the only other medication i am on besides what I get from him. Did the adderal clear out my system bc I have NO other explanation as to why it didnt show up! Now I am searching for a new doctor which really sucks bc I do not have time to do this but i HAVE to have my medicine! Please HELP!!

REPLY

Was this helpful? 0

Confused,

There have been a lot of posts recently that are just like yours. People's medications are not showing up on their drug test and others are getting false positives.

If it was just one or two people, I'd think they had screwed up and just didn't want to admit it, however, there have been so many that it leads me to conclude that we have a bad bunch of tests on the market.

I am sorry for what you're going through and wish there was some way I could help.


Please post back and let us know how you are doing.

REPLY

Was this helpful? 0

Whats odd is that my roomate, he was in a horrible car accident as well and lost most of his toes and part of his foot among various other problems and is now considered handicap. Obviously he is in severe pain as well and he sees his dr from his home town ab an hour away bc of his health insurance. About 2mnths ago he came home upset bc of this problem and I felt bad for him bc i KNOW 100% he takes his every day. He is n such bad pain that sometimes he even runs out a day or two early and will borrow a couple from someone. So i was super confused as to how that could happen to him! Then last week at my doctor it happens to me and they are an hour away from each other. I am not some junkie or whatever I have a legitimate disease thats awful and prevents me from working or doing ANYTHING whatsoever without the medicine. I dont WANT to b dependant on nething but i do not have a choice if I want to lead a somewhat normal life. Ive never abused the meds or gotten high off of them. I ONLY take them as rx'd and needed and I take 6 a day every day. So I am at a loss as to why this happened and what to do bc I didnt even get to SEE my doctor the nurse told me I was discharged. I called back and tried everything I could to prove I took them and if i could retest or anything to fix this matter. I dont understand what they think I did with them??!! Why would I pay hard earned $, take off work & drive to the DR. then pay for the Rx's if i wasnt gonna take them & just gonna let them sit in my medicine cabinet? Thats RIDICULOUS!! Obviously something is wrong but they dont care & now I have to suffer for something I didnt do nor had ANY way to prevent!

REPLY

Was this helpful? 0

Confused, I agree with you that something is definitely wrong.

Even if both of these doctor's offices are that far away from each other, they probably both use the same drug testing kit. Most offices will purchase from whichever supplier is the cheapest at the time they are restocking their shelves, which means the same manufacturer is often used by most of the doctor's office across the country.

I really wish I knew what you could do about this situation, but I don't.

It would help if they had to retest you if you protested, or had to perform a hair test of something, that would prove you took them, but they don't.

I do, however, wish you the best of luck and hope that in the future you find a much better, more understanding doctor.

REPLY

Was this helpful? 0

How long will an Opana 40mg stay in your system? I took 1 opana 40mg and had a drug test 13 days later (urine) at the hospital lab. Will this show up in the drug screen or am I safe? Thanks for the help I'm really worried

REPLY

Was this helpful? 0

How long will a 5mg (one) stay in my system , I took it 9am today , I have to do a quick urine test at probation by 11:30 tomorrow .

REPLY

Was this helpful? 0

Home » Pain Treatments » Pharmacological » Opioids
Oxycodone to Oxymorphone Metabolism
Interpreting urine drug tests in pain patients treated with oxycodone requires an understanding that oxymorphone, although considered a minor metabolite, can sometimes equal or exceed urine concentrations of oxycodone.
By Jennifer Schneider, MD and Ashley Miller
Page 1 of 2

Primary care physicians, as well as pain specialists, are increasingly ordering urine drug tests as part of the initial evaluation and follow-up of patients with chronic pain when opioid therapy is being used or is under consideration. Physicians should know that ordering a urine drug test (UDT) carries with it an obligation to understand the results and to act on them accordingly, instituting changes in treatment plan if indicated.

Interpreting UDT results can be confusing unless physicians understand the metabolism of opioids. For example, it is well recognized that codeine is a pro-drug, with its analgesic effect resulting from conversion of codeine to morphine by the cytochrome P450 2D6.1,2 Thus, patients on codeine frequently test positive for both codeine and morphine. When patients who lack the cytochrome P450 2D6 enzyme necessary to convert codeine to morphine are treated with codeine, their urine may show only codeine.2 On the other hand, a finding of codeine in the urine of a patient being treated with morphine implies that the patient was also obtaining codeine from another source. Similarly, hydrocodone is metabolized to hydromorphone, so that both may legitimately be found in the urine of a patient who is being prescribed hydrocodone (Vicodin, Lorcet, etc.)3,4 But again, the reverse is not true; a patient prescribed hydromorphone (Dilaudid) should not have hydrocodone in the urine. Recently, Cone et al5 reported that in some patients chronically treated with morphine, hydromorphone can appear in the urine as a result of a minor metabolic pathway.

An extended-release oxymorphone (OpanaER) and an immediate-release oxymorphone (Opana) have recently become available. The question then arises, what is the explanation for a finding of oxymorphone in the urine of a patient who is not being prescribed this drug? Oxycodone is metabolized in part by cytochrome P450 2D6 to oxymorphone, which represents less than 15% of the total administered dose.6 However, oxymorphone has a significantly longer half life (7-9 hours)7 than does oxycodone, whose mean elimination half-life following a single, oral dose is 3.51 ± 1.43 hours.8 It is therefore plausible that in oxycodone-using patients, serum and urine levels of oxymorphone may be significantly more than 15% those of oxycodone. Large numbers of patients consume oxycodone, either as the extended-release form (OxyContin) or as immediate-release Percocet, Percodan, or its generic equivalents. The present study was designed to obtain information on the frequency and concentration (in ng/mL) of oxymorphone in the urine of patients prescribed oxycodone.
Methods

Over a two-month period (March and April 2007), all 175 patients in a chronic pain practice were asked without advance notice to submit a urine specimen. The patients were being treated for various types of chronic non-cancer pain, with back pain being the most common diagnosis. Eighty-eight patients who were being prescribed oxycodone (extended-release and/or immediate-release) were tested for oxycodone and oxymorphone by an enzyme immunoassay (EIA). Because the usual immunoassay screen for opiates will not pick up oxycodone and oxymorphone, the order was written as “Routine urine drug test plus oxycodone and oxymorphone.†Each patient’s daily dose and time of last dose were recorded by the medical assistant, who also checked the temperature of the urine immediately after voiding to be sure it fell within the range of 90-100 ºF. Two of the patients had UDT results that were negative on immunoassay for oxycodone. They were excluded from the remainder of this study. For 48 of the remaining 86 patients who tested positive for oxycodone on immunoassay, the urine concentration of oxycodone and oxymorphone was determined quantitatively using gas chromatography/mass spectrometry (GC/MS). The cut-off level for a “Positive†oxycodone or oxymorphone result was 100 ng/mL.
View Sources

1
2

Next
Last

First published on: October 1, 2007
0 0 Digg0
Related Articles

Non-responsive Pain Patients with CYP-2D6 Defect
Opioid Treatment 10-year Longevity Survey Final Report
Why Some Patients Require High Dose Opioid Therapy
Urine Drug Testing as an Evaluation of Risk
FDA’s Proposed Risk Evaluation and Mitigation Strategy (REMS) for Opioids
Making Practical Sense of Cytochrome P450

Pain Treatments

Bracing/Splinting/Prosthesis
Complementary Treatments
Hormone Therapy
Interventional Pain Management
Manipulation and Massage
Nutraceutical
Pharmacological
Non-opioids/OTC
Opioids
Psychological
Rehabilitation

Email
Print
RSS
Tweet

This article was first published in:
Practical Pain Management
Volume 7, Issue #8
Also in this issue:

A Clinical Guide to Weaning Off Intrathecal Opioids
Avoiding the Pitfalls of Opioid Reversal with Naloxone
Burning Mouth Syndrome
Central Role of Dopamine in Fibromyalgia
CES in the Treatment of Insomnia: A Review and Meta-analysis
Chronic Pain Program in a Primary Care Setting
Chronic Persistent Pain Can Kill
Combined Phrenic Nerve Palsy and Cervical Facet Joint Pain
Dextrose Prolotherapy for Unresolved Neck Pain
Education and Exercise Program for Chronic Pain Patients
How—and Why—You Should Get Better Connected to Your Patients Over the Internet
Low Level Laser Therapy - Part 1
Managing Pain in Intensive Care Units
Mistakes Made by Chronic Pain Patients
Near-infrared Therapeutic Laser and Pain Relief
Patulous Eustachian Tube: Part 1
Patulous Eustachian Tube: Part 2
Rational, Emotive, Ethical Approaches To Bio-Psychosocial Pain Care
Smoking and Aberrant Behavior in Chronic Pain Patients
Structuring Opioid Therapy
The “Promise†of Pain Medicine: Profession, Oaths, and the Probity of Practice
Three Dimensional Imaging Of The Foot
Using EMRs to Make Your Patient “Triage†and Clinical Flow More Efficient.

Which of the following is your greatest challenge when prescribing opioids to pain patients in a safe and effective manner?
Identifying patients with potential complications
33%
Identifying potential abusers and those with drug seeking behavior
33%
Promoting patient compliance/dosing
0%
Formulary status/ insurance coverage/ cost to patient
33%
Other
0%
Practical Pain Management
Subscribe to PPM and get a FREE Practice Listing. Sign-up now! or Log In

Types of Pain
Pain Treatments
Resources
Continuing Education
Past Issues

Advice for Patients
Types of Pain

Acute Pain
Cancer Pain
Headache
Neuropathic Pain
Oral and Maxillofacial Pain
Rheumatologic and Myofascial Pain
Spine Pain
Other Types of Pain

Pain Treatments

Bracing/Splinting/Prosthesis
Complementary Treatments
Hormone Therapy
Interventional Pain Management
Manipulation and Massage
Nutraceutical
Pharmacological
Psychological
Rehabilitation

Pain Resources

Clinical Practice Guidelines
Diagnostic Tests
Ethics and Legal
Hospice/Palliative Care
Practice Management

Policy and Contact

About PPM
Press Releases
Advertising Opportunities
Editorial Guidelines
2011 Media Guide

Privacy Policy
Advertising Policy
Terms of Use
Contact Us
For Patients

©1999 - 2011 Vertical Health LLC
Vertical Health Media, LLC does not, by publication of the advertisements contained herein, express endorsement or verify the accuracy and effectiveness of the products and claims contained therein. Vertical Health Media, LLC disclaims any liability for damages resulting from the use of any product advertised herein and suggests that readers fully investigate the products and claims prior to purchasing. The views of the authors are not necessarily those of Vertical Health Media, LLC.

Practical Pain Management is sent without charge 9 times per year to pain management clinicians in the US.

Use of this website is conditional upon your acceptance of our user agreement.
Vertical Health LLC

REPLY

Was this helpful? 0

IT IS AMAZING HOW I'M ON THE SAME MEDICATION AS THIS PERSON, AND THE ADDERRALL WOULD ALWAYS SHOW IN MY URINE, BUT THE PAIN MEDICINE, WHICH I TOOK EVERYDAY, WOULD NOT SHOW, AND A SPECIALIST EXPLAINED WHY. OXYCODONE, TURNS INTO OXYMORPHONE INSIDE SOME PEOPLE WHO HAVE A SPECIFIC ENZYME IN THEIR BODY. I HAVE PASTED THE WHOLE ARTICLE, AND IF I WAS THIS PERSON WHO WAS PUT OUT OF THEIR PAIN CLINIC, I WOULD COPY THE ARTICLE, AND BRING IT TO MY PAIN CLINIC AND SHOW THEM THAT THEY UNJUSTLY KICKED THEM OUT OF THE PROGRAM.

REPLY

Was this helpful? 0

white pill - number 512 imprinted on pill ## This tablet contains 325mgs of Acetaminophen and 5mgs of Oxycodone, a gener...

1 REPLY

white round pill with 512 is on it ## The pill that you are describing which is white and has 512 on it is Acetaminophen...

4 REPLIES

is there any nightmaires associated with taking this medicen? ## The Oxycodone in it is a narcotic opiate, so it can cau...

6 REPLIES

Is there weight loss when taking this pill? ## Oxycodone with Acetaminophen is a generic for Percocet and weight loss is...

1 REPLY

what this looks like ## This is a generic for Percocet and as a generic, I cannot possibly list all the markings and des...

7 REPLIES

I am having a mri tomorrow ......I am very claustrophobic so dr gave me a Valium RX....to relax me.....I am wondering is...

2 REPLIES

I would like to know what apap means? What does 10 mean and 325 mean? I know it means amounts of drug but what drug, and...

2 REPLIES

Having bad headaches. Seeking relief. I'm out of other pain relieving medication and my Dr. is not available. I took...

1 REPLY

I have been on Tylox, dilaudid, and Extended Release Hydricodone and Exteneed Release Opana for many years due to an MVA...

1 REPLY

how much codone is in it, what is the difference between generic and the real oxycodone ## This means there are 5mgs of ...

1 REPLY