How Long Does It Take For Linzess To Get Out Of Your System

ike Says:

how long does it take for linzess to be completely out of your system

17 Replies

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Sandy Says:

How long does it take linzess to get out of your system?

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David Says:

@ike / sandy,

From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes.

[1] source: PubMed / PMC3638410

That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame.

Hope this helps!

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Tan Says:

How long does it take for linzess to get out of the body

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Jo Says:

How long does it take for Linzess to get out of your body

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Cathy Says:

Re: Tan (# 3) Expand Referenced Message

I am 115 lbs and i feel the effects of Linzess for at least 2 days. I get bloating and gas. I am now on the 72 MCG but am still feeling after effects.

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Kitty Says:

Re: David (# 2) Expand Referenced Message

Thank you David. I am very worried. My Grandson has had chronic constipation since birth. Dr's tell us to give him mirilax, did. Didn't do any miracles but helped. Now that he's 16 he refuses to take the powder, it's gritty and he says tastes awful. Anyway, my concern now is for 4-3 days he hasn't went, he's very tired, nauseous, been sent home 2 days in a row this week because of feeling tired and feeling bad and nauseous. So I gave him one 145 mcg Linzess capsule tonight at about 8:59pm. He kept trying go before and no go. So I thought the bottle said, do not give to children under age 6. It did. So I gave him one. Then went to read how long before it may work, and read 'don't give to children under 6 at all, or between 6-18 years of age'. I am now freaking out. Please let me know if you think 1 pill will hurt him. As you can see I can not sleep. Appreciate any advice.

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David Says:

Re: Kitty (# 6) Expand Referenced Message

I'm very sorry to hear about your grandson. I hope he's gotten around to feeling better since the timing of your post. Unfortunately, since there's no way of knowing ahead of time how anyone will react/respond to pharmaceutical medications, all I can do is encourage him to consult with a doctor when it comes to prescription drugs such as Linzess... However, I don't know if you heard of Essiac tea leaf, but it works miracles for me and my family whenever serious indigestion occurs, so I just thought I'd mention it as another possible avenue of treatment. I'm actually very hesitant to take it unless the problem is severe because it works almost too well. All you need is an 8oz cup full and it seriously cleans you out like nobody's business, LOL! I believe it is readily available at most health food stores as well as Amazon and other internet retailers. Please let me know if I could be of any more assistance in this matter.

Wishing you both good health always!

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Sassy Says:

Re: Sandy (# 1) Expand Referenced Message

I don't know but I had a allergic reaction after the 3rd pill. It started in my mouth broke out and swelling of the tongue. Couldn't eat for a week.

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Barbara Says:

I'm having cold like symptoms after taking Linzess, how long will these symptoms continue? They are quite annoying.

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Pat Says:

Re: Barbara (# 9) Expand Referenced Message

I am feeling the same way after taking linzess, headache, dizziness, diarrhea, feeling cold.

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Diane Says:

Re: Cathy (# 5) Expand Referenced Message

Very dangerous drug. Just got off. Cover up of this drug

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Karyn Says:

How long does it take for Linzess to leave your system?

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NinaBaker Says:

Re: Pat (# 10) Expand Referenced Message

Same I took 75mg yesterday and I have a headache stomach pains etc. unfortunately this is the only medication that lets me go. But the side effects I get cold shaky I feel like I’m going to pass out I get extremely dizzy I hope I can find something else that works and doesn’t cause so much discomfort.

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AngelaRDH Says:

Re: Diane (# 11) Expand Referenced Message

Please, pretty please, explain!

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Jesse Says:

Re: NinaBaker (# 13) Expand Referenced Message

Iv been on linzess for bout 3 to 4 weeks now and I've had this happening to me. Also so I stopped taking it but I'm still getting the pass out feeling with getting lightheaded and dizzy. Was in the ER for it last night. Pretty scary. How long until that went away for you after u quit taking it?

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Healthy til Linzess Says:

Re: Jesse (# 15) Expand Referenced Message

I have had heart palpitations for 2months since stopping Linzess. I now see a heart doctor as I can't sleep and have dizzy spells regularly. This medicine is evil and causes this problem in 100% of women, 50% of African Americans and 33% people between 50-59. I fall in all categories and don't know when I will recover.

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Mary Says:

My friend gave linzess for a joke

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