Formulation Change Of Levoxyl

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John Says:


I took Levoxyl for about 10 years. I have tried almost all other drugs synthroid, unithroid, armour, cytomel and Levoxyl worked the best, when it went off the market they put me on generics and that didn't work. I than tried tirosint that was stronger than my 137 mg levoxyl. When I heard Levoxyl was again available I got my prescription refilled and thought I'm going to feel better again. I did'nt, I'm not sure that they haven't changed the formulation . Has anyone else had the same situation?



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Albina Says:

I've taken it for 24 years prior to it going off the market & always felt fine. Since it was reintroduced I also have not felt well. In fact on the same dose, my TSH was 19.8 when analyzed 11/2015!! Doc has no answer for me. Thinks it is absorption problem. I told him I read that the drug is now produced in Austria and wondering if they are using cheaper fillers. He essentially told me I was crazy. Have you had your TSH rechecked since restarting Levoxyl?

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David Says:

@Albina.

I think the idea of different or cheaper fillers being used is certainly a strong possibility considering that it's the one area drug companies seem to have a lot of leeway with; in so far as being able to use pretty much whatever binding agents they want without any strict guidelines per say (that I know of).

But going back to your doctor's thoughts on this potentially being an"absorption problem", my guess is as good as his. On the other hand I don't see why the doctor doesn't understand that binders/fillers play a role in drug efficacy... taking brand name vs generic drugs for example; which often vary greatly in terms of how well they work, despite having the same active ingredients.

Just wanted to share my opinion on that. Hope all is well with you!

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Barbara Says:

I suffered with last Lexoxyl recall. Finally went back on it last year and still felt bad. I found that it's not as strong as old one. I have increased my dose and that helped. I can't take anything else so I hope that doesn't happen again!

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