Cytochrome Pathways Hydrocodone
Updatedwhat is it? - cytochrome pathway cp-450; etc
1 Reply
Hello, David! How are you?
They are a superfamily of proteins which contain a heme cofactor, so they are hemoproteins. They use various large and small molecules in substrates of enzymatic reactions.
Human CYPs are primarily membrane associated proteins that are located in the inner membrane of mitochondria or in the endoplasmic reticulum.
They are the major enzymes involved in drug metabolism, they actually account for about 75% of it. Most drugs undergo deactivation from CYPs, either directly or through excretion from the body. Some drugs can increase or decrease their activity. This could cause you not to absorb enough of any given medication or to absorb too much of it.
A good example to use is the antiseizure medication Phenytoin, since it uses some of the same substrates, if taken with other medications, like Amiodarone or Carbamazepine, it could increase them to toxic levels or reduce them to a level of inefficacy.
Hydrocodone is metabolized via the CYP enzymes.
The FDA lists this medication as being a narcotic analgesic, so it has the potential to be habit forming and may cause side effects, such as nausea, dizziness, drowsiness, dry mouth and constipation.
Do you have any other questions or information to add?
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