Contrave And Sleepiness

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Cris Says:


I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sleepy I can't stand it. Days 1 and 2 I managed to fight it off until about 12-12:30, day 3 until about 1-1:30, and day 4 I fought it off until 3pm. If I take a 1-2 hour nap, I wake up fine, with energy and then cannot get to sleep until about 2am, sometimes 3am. Today is day 5, I'm having that "drunk" feeling and sleepy, but no where near how it has been. It seems this effect is slowly wearing off, but I haven't seen anywhere where this is a common side effect. I know all medications effect everyone differently, so I'm wondering if this is something I should be concerned about, or just another side effect that I will get used to as the weeks go on?


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JH Says:

I've had the same reaction (along with other)/side effects. Mine are disapating - and I've tried not to actualy take a nap - just sort of rest and then get back up.

I also increased the amount of water I drink and that seems to have mitigated some of the SE.

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Cris Says:

Thanks for your reply. I found that the more days go on, the better it has gotten. Today is day 6 and while I still had that drunk feeling, today is the closest to normal I've felt. I am noticing afternoon headaches now, which ibuprofen seems to help. How long have you been taking it? Have you noticed an weight loss?

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David Says:

Hi Cris,

Sorry to hear about your experience with Contrave (naltrexone HCl + bupropion HCl) and sleepiness. I just wanted to add as validation that NIH.gov does list drowsiness and trouble sleeping as side effects of bupropion. Their website also lists: unusual tiredness, drowsiness, restlessness and trouble sleeping as side effects of naltrexone. I question whether these symptoms are playing a role in your ability to get back to a "normal" sleep schedule...

Depending on how serious these side effects are affecting your livelihood and well-being, it may be worth talking with your doctor about how you're feeling in order to see if he/she has any recommendations that can help offset or minimize symptoms.

One last thing I wanted to mention that also concerns me (and is slightly off topic), is that "HCL" also known as Hydrochloric acid is actually classified as "poison" which, if you look it up, does list some undesirable side effects as well, that many people who take pharmaceutical medications aren't aware of. The manufacturer's website for Contrave lists HCL as an ingredient, which triggered me to inform you of this in case it might've been contributing to how you're feeling in any way.

I hope this helps and wish you good health!

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Amanda Says:

I had the same tiredness you have along with constipation on the highest dose. I had to get off and may go back on Qysmia but that made me jittery. I lost 25 pounds quickly on Qysmia and 15 pounds in Contrave in the middle dosages but at the high on both had too many side effects.

Where is our miracle diet pill!



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Amy Says:

I started contrave last year. I have lost 28 pounds so far. when I first started contrave I was EXTREMELY sleepy. this lasted for a good 2 weeks. it did get much better. I am very happy with it, and am trying to loose anothre 20 pounds.

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Crickett Says:
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Thank you for letting me know a timeline about how long the drowsiness last i just started contrave 2 days ago....

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Susan Says:
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I just filled a prescription for Contrave and wanted to begin taking it tomorrow, but I drive a company vehicle and cannot be drunk. Definitely can't take a nap on the clock. After all the drowsy reviews, I will probably wait till the weekend & see how I respond. Also very hesitant to be nauseous??

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Lagene Says:

I just started taking 1 twice a day yesterday and I am so sleepy. I was that way the first 4 days but now it's back even worse! I'm ok with that because I think it will pass again, at least I hope...I just sit in my chair in the morning and stare and doze off...

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Susan Says:
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I tried it for a weekend. Wasted $150, No way I can feel that horrible, even for couple weeks. No wonder you can lose weight. Totally bedridden

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Ellen Says:

Well - since there is no fantastic "diet" pill -- I am still using Contrave at the standard full dosage of 2 - twice a day. I don't say morning and night because adjusting the time for me to lunch and dinner with some has made a notable difference in the efficacy of taking it.

Side affects -- I had nearly every awful side effect and it took me nearly six weeks to work through all of them horrible horrible nausea, sleepiness (the lightest weight side effect for me) headaches, sleepliness -- constipation, diahrea --- all said and done it has been worth is because for me, at least it cuts the ravenous hunger I feel otherwise. I don't see it as a miracle rather an effective, if not perfect tool to help me....

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Kkfrazier2 Says:
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Ugh... same for me, sooo sleepy. Now it's not as bad (day 8) but I feel awful today, migraine all day, and oh so nauseous! Also woke up with very sore calves...? No exercise, maybe I had leg cramps last night and didn't notice? I usually would wake up from that though. Needless to say I'm not sure how long I can stick with this, lots of side effects, have noticed less urgency to eat everything but not weight-loss.

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Jan Says:
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Does it matter if you take Contrave at night? Maybe that would help with the sleepy feeling.

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Totired Says:
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I just started this drug day 2 of one pill twice a day.. I can't stand this drunk loopy drugged up feeling. Hope it goes away soon. Have to busy of a life to feel this way for to long

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CJ Says:
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What about taking it at bedtime?!? If it makes you drowsy wouldn't it be just as effective if you took contrace at bedtime? Just a thought. I haven't taken this medicine yet, in just checking out people's experiences first!

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Angie Says:
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Holy Crap. I CANNOT BELIEVE the FDA approved this. What you all are taking is an anti depressant(Wellbutrin) with a medication used to treat opiate addiction. How do I know? I am a recovering addict. I've tried every opioid pill there is and I know A LOT about them. This pharmaceutical company is setting up so many people to become opiate addicts!!! I know from EXPERIENCE. I just started on suboxone and I can't sleep, I'm up all night, headaches the nausea. Those side effects are the same as opiates!!! You're vomiting because this drug.has attached itself to your opioid receptors in your brain. I just pray you guys really research this med before continuing. All the side affects are cause you're high as a kite but you don't realize smh I just can't believe this

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denise Says:
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The medication has naltrexone in it, used to stop the abuse of opiates...keeps them from sticking to the receptors. so or is not addictive

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losingweight Says:

I am on week 2 of 1 pill 2x daily and I'm very sleepy about an hour after taking it but I'm able to stay awake. No nausea or other side effects. I notice that I do stop eating about halfway through my meal and I'm able to resist night time snacking. I've lost 11 pounds so far.

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CRISSI Says:

THIS IS MY SECOND TIME TRYING CONTRAVE , THE FIRSST TIME I LOST 40 LBS IN ABOUT 4 MONTHS AND THEN THOUGHT THAT WAS THE JUMP START I NEEDED I STOPPED TAKING IT FOR ABOUT A MONTH AND GAINED BACK 8 LBS, NOW IM BACK ON IT IN 4 DAYS LOST 3 LBS TIRED ALL THE TIME AND CRANKY, BUT I KNOW AS TIME GOES ON THIS WILL WEAR OFF AND I WILL CONTINUALLY LOOSE WEIGHT AND ALL SIDE EFFECTS WILL BE GONE. ITS GREAT !!!!

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DelrayBeach Says:

It's weird reading all these comments because I had a very great experience with this drug. I started it at night not the morning. I believe the instructions even say to do that. Also, I had extreme anxiety prior to taking it. Suddenly feeling calm and relaxed was a welcome relief for me. I felt amazing. I'm using the drug to quit drinking and smoking that I was doing a couple times a week due to my anxiety but couldn't stop. However, I also need to lose ten pounds that won't seem to come off. When I went up to two pills a day too soon, I did have sleeplessness and anxiety, so back to the one pill per day until my body is ready to increase. I'm also regulating my hormones because I'm over 50 and taking oral progesterone at night helps me sleep. Since the day I started taking it, the drug has done everything it is supposed to do. I'm just hoping and praying for continued success.

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Krickett Says:
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I never hd that problem.
Love taking it but got to expensive.
Did loose weight.

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