Conceiving A Baby While On Xalkori/crizotinib

Hello,

I am new to this forum and pleased to meet you all. My partner, a 27-year old man is being treated with Crizotinib since September 2012. He was diagnosed with Non-Hodgkin Anaplastic T cells Lymphoma ALK+. After chemo we decided to continue his treatment with Crizotinib (on a clinical trial) rather than following the standard path of autologous stem cell transplant. He has never suspended the treatment apart from short periods (10 days) when his blood work showed he needed to (low white cells). He has been on complete remission since (he actually had a negative CT scan also before starting but his PCR/NPM-ALK from peripheral blood was positive suggesting the illness was still present in the blood and a high chance of relapse).

Being a fairly young couple we have been wondering about fertility and the possibility of having a baby. Before starting chemo he had cryoconservation. Nevertheless, his Professor said that we could try to conceive naturally since the worry would come when the woman takes the drug not the man. After a few months not taking any contraception, I found out I was pregnant last week (05/03/2015). I repeated the home diagnostic on the Saturday (07/03/2015) and again positive. We were over the moon. Sadly, I had a very early miscarriage on Monday 09/03/2015 which was confirmed at the A & E. I am worried that the Crizotinib may in fact affect the quality of his sperm but there are no data based studies on men, just some preliminary studies on rats:

ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002489/WC500134759.pdf (paragraph 4.6 and 5.3).

I am wondering whether anyone has been successful in conceiving a healthy baby while taking Crizotinib. There is no planned suspension in the clinical trial. Any doctors or patients out there with any experience/knowledge? Many thanks for your help in finding some more information. All the best to anyone and long-lasting remission to all the cancer patients!

Love,
Giulia

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Hello, Giulia! How are you?

The doctor was correct, the main concern would be if the woman were taking it, not the man. If he has viable sperm then any concern usually ends there and the miscarry was likely due to something wrong in your body, or with the fetus itself.

Have you consulted an OB Gyn for evaluation? A miscarriage can be caused by something as simple as stress, or being low in Progesterone, as listed by the NIH.

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Hello!
I'm very pleased to inform you in 21 weeks pregnant! Got pregnant naturally 2 months after the miscarriage and all is going well, we are expecting a baby girl! I'la keep you updated!
Thank you for your help and support!

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Hi Guilia
I'm in the same position as you my husband is 29 and was diagnosed last year with terminal NSCLC we are on the Crizotinib treatment. I just found out two days ago I'm pregnant and wanted to know how your pregnancy went as I also can't find a lot on this subject.

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Hello
Our beautiful baby daughter Isabel will turn 5 months on Tuesday. She is beautiful and healthy, the most precious gift in our life. She was born on 5 February 2016 by emergency c section in Cambridge, UK.
Enjoy your pregnancy, live it to the full and enjoy becoming a mum, it's wonderful!

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