Hydroxyzine And Bupropion

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Hi. Can someone tell me if there are any possible side effects from taking these two medications together?

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Hello, Nefer!

I didn't find any problems or interactions listed between these two medications. However, according to the MayoClinic, Hydroxyzine is on the list of medications that is usually not recommended for use alongside Bupropion, even though it may be required in some cases. They go on to note that if both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ref: MayoClinic

Hydroxyzine is classified by the FDA as an antihistamine that is also used for its sedating properties. Its typical side effects may possibly include nausea, dizziness, dry mouth and drowsiness.

Ref: MedlinePlus (Hydroxyzine)

Bupropion is an antidepressant and smoking cessation aid. Its typical side effects may include nausea, dizziness, headache, dry mouth and mood changes.

Ref: MedlinePlus (Bupropion)
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Is this medicine also used for withdrawal symptoms from alcohol or opiates?

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I read somewhere that using it can increase your risk of seizure with bupropion. Though your dose for bupropion needs to be increased and you would need to take your hydroxyzine at the same time for the seizure risk to be heightened. If you're taking Wellbutrin for depression and hydroxyzine as a sleep aid, no increased risk of seizure should occur from just taking your Wellbutrin normally.

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