About Nusam

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Deepak Says:

I am suffering from GOUT due to uric acid. every year it occurs twice ie after 6 months regularly from last 5 years. generally it use to be for 4-7 days, but this time it has attacked more than a month. Along with endocap SR, doctor has prescribed me NUSAM 400. Does it have any side effect if I take these medicines for more than a month? Kindly suggest me.......

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Jenna Says:

Hi Deepak,

Based on my research, NUSAM 400 is a nutritional supplement that contains the active ingredient S-Adenosyl methionine (ademetionine, AdoMet, SAM, SAMe, SAM-e).

In the United States and Canada, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee" or "Sammy"). SAM is also marketed under the Gumbaral, Samyr, Adomet, Heptral, Agotan, Donamet, Isimet and Admethionine brand names as a prescription drug approved in Russia, Italy, and several countries within the European Union. Some research, including multiple clinical trials, has indicated taking SAM on a regular basis may help fight depression, liver disease, and the pain of osteoarthritis. All other indications are not yet proven.

How to take:

SAM is best absorbed on an empty stomach. Enteric-coated tablets packaged in foil or foil blister packs increase stability and improve absorption. SAM should be stored in a cool, dry place to prevent deterioration.


Adverse effects:

Gastrointestinal disorder, dyspepsia and anxiety can occur with SAM consumption. Long-term effects are unknown. SAM is a weak DNA-alkylating agent.

I've heard that it's expensive so you may want to consider asking for a less expensive generic version of this medication, if there is one available.

Do you have anymore questions?

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ashwin Says:

I have been prescribed this med for liver pain, can any one tell me what is weak DNA alkylating agent, does taking nusam 400 cause DNA damage?

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