Which Is Better? Hydrocodone-apap 7.5-650 (watson 502 Pink Tablets Or White Scored Oblong M359)?

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Amanda Says:

I am on pain pills to manage the chronic pain I experience from Fibromyalgia, Systemic Lupus Erythematosus, Neuropathy, and back/disc problems. We moved, so I just changed pharmacies. I get a Rx every month for hydrocodone-apap 7.5-650 (used to get 10-650's but couldn't stand the nausea, so I asked them to bump it down a bit). I used to get the pink pills that had WATSON 502 (I think it was) on them, generic for Lorcet Plus. Now I filled the same Rx at the new pharmacy and they gave me some white scored oblong tablet that says M359. It also says generic for Lorcet Plus tablet. Can anyone please tell me if there is a difference other than the manufacturer of the pills? (like, if one is better than the other). The old ones (WATSON) seemed like they took forever to kick in and at times would make me nauseated. The new white ones seem to do better. They seem to kick in faster, ease the pain just as well but seem like they might not last quite as long. Just wondering what other's experience has been with them and if other's have noticed any difference. Thanks for any replies. :)

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David Says:

Hi Amanda,

Both of the pills in question are one in the same drug. The only difference I noticed is that they are manufactured by different companies. Additionally, there may be a slight variation of inactive ingredients; but other than that you can be assured that they are the same drug and same dosage.

Certain "inactive" ingredients that may or may not be present in each brand, are actually detrimental to how the drug is metabolized and used by your body. Because everyone is different, your body may agree with one medication over the other, due to how you feel or based on whatever side effects present themselves.

When you switch brand names, the drug itself doesn't change, but rather the binders or fillers that they put with it.

I was unable to find an inactive ingredient list for the older pink ones you described, but I did find a list for the white M359 pills:
crospovidone
magnesium stearate
microcrystalline cellulose
povidone
corn starch
silicon dioxide
stearic acid

I hope this helps! :)

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Dr Brandon Says:

You are interesting. Research indicates you have a pain amplification problem as well as a dependency on opiates. I am not as all saying your pain is not real, but opiate effectiveness will decrease and your pain will increase because of your brain ability to adjust to your daily medications. I would recommend hormone blood work and SSRIs to bind to some receptors or a muscle relaxer to increase the efficacy of the opiates, along with nutrition changes, PE, and electrolyte hydration. I am sure you are eating GMOs, sugar, yeast, you shouldn't me. Moreover, opiates do stop working after a continuous use. Consider discontinue use for a 1-3 month period, and once you resume opiate treatment, it will make them more effective for 6 months to a year. Also, include a muscle relaxer in addition to the pain killer if a SSRI is not desirable.

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