Taking Phenergan And Zofran Together

Wendy Says:

Hello. I have been prescribed Phenergan via IV PICC line for nausea in combination with Zofran IV as well. Do these meds work well together? I do seem to be having side effects of blurred vision, itching and some abnormal feeling in my legs that makes me feel as if I must move or get up and walk. Is this a side effect or just something else going on?

3 Replies

Earliest Newest Votes
David Says:

According to the University of Maryland Medical Center (umm.edu / drug interaction tool), there is a dangerously high interaction potential between the active ingredients in Phenergan (promethazine) and Zofran (ondansetron); which states that taking the two together may cause serious problems with your heart.

Further details suggest that if these two medications are necessary, your doctor may adjust the dosage, timing and/or frequency of administration in order to lessen such risk factors.

They go on to note that you should contact your doctor immediately if you experience: Chest pain or discomfort, shortness of breath, unusual heartbeats, dizziness or lightheaded, feeling like you're going to pass out, or feeling very weak.

I hope this information helps!

Was this helpful? 0
Wendy Says:

Re: David (# 1) Expand Referenced Message

Thank you very much for the info. I will pay close attention to my body if any of those symptoms happen! So far, it's just the blurred vision, itching....but the moments are becoming greater in frequency and intensity. I take Benadryl to help with the itching, but sometimes comes a few hours later and it's mainly my face that itches. I also take oxycodone now. This itching is so intense! Any advice?

Was this helpful? 0
Green Says:

Naw, you exactly right. When I take too many promethazine in a days time without any other opioid, I start to get that restless leg syndrome to where I can't keep my legs from moving. I hate that feeling cause it's so uncomfortable when that happens.

Was this helpful? 0

More Discussions:

taking suboxone and phenergan

need to kno if i can take 4mg suboxone ang 50mg phenergan? ## My findings state that there are potentially unsafe intera...

Toradol, Morphine, Zofran and Phenergan injections

Is 2mg morphine, 60 mg toradol, 4mg zofran and 25 mg phenergan (all injections) given to a 36 y/o female weighing 190lbs...

taking inegy and pritor together

I'm on heart medication (Inegy, Pritor, Cardicor, and Ecotrin) and am now suffering from terrible aching of all my j...

Taking telma and atenolol together for hypertension

I am age 70 and taking Telma 40 but my blood pressure is not under control (160/110). I have scarring in my lungs and re...

Taking Amtas and Diltiazem together

Please tell me if the combination of Amtas and Diltiazem is safe or if it has some side effects for a heart patient? ## ...

Taking Baclofen and Soma together

Is it safe to take Baclofen and Soma together? I have not done it yet so I'm a little leery, but I hurt all over due...

Taking Dayvigo and Ativan together

My Dr says take Dayvigo and Ativan together while I wean off ativan. Has anybody else done this? ## Have not taken, but ...

Taking Exforge and Alteril Together

Can I take Alteril when I currently take Exforge to control blood pressure? ## After gathering information regarding Exf...

Taking subutex and percocet together

My doctor just put me on subutex along with percocet. I've been on percocet for yrs for severe and chronic migraines...

Taking Lipozene and Xarelto together

Can lipozene and xarelto be taken together? Are the effects of xarelto and lipozene compatible? ## Hi Lynne, From what I...