Sublingual Drug Usage And Inactive Ingredients

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Schleprock Says:


When you have the option of taking a drug sublingually, does taking it in that fashion in any way dissolve away or lessen the impact of the inactive ingredients, rendering the intended drug effects more equal between brands?



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Schleprock Says:

I'd also like to add whether the bioavailability of the drug between two brands becomes more identical when the drug is administered sublingually as opposed to swallowed.

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Kevin Says:

Hello Schleprock,

All routes of administration of the same dosage of a drug regardless of brand are required by the FDA to meet a standardized number of the active ingredient entering your blood stream. For example all generic versions of 100mg tylenol (acetaminophen), regardless of administration route, are required by the FDA to have +/- 20% of amount of acetaminophen in your blood stream as the tylenol brand does. The reason that generics offer a variety of administration options is for people who are unable to use a particular method.

This means that regardless of the administration or inactive ingredients there is still a FDA requirement that the same amount of the drug get into your blood stream as the brand name. So in a perfect world all brands/generics would be equal but where this falls short if that some people's body reacts better to certain inactive ingredients which understandably results in them forming opinions of which brand is the best. Some brands are touted as the best but really they only have the most tolerated ingredients among the general masses.


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