Splitting Contrave Pills

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Lori Says:

I just started Contrave last Friday. I have really had no side effects, but because I have a narrowed esophagus, I have trouble swallowing the pill (it gets stuck). I cut the pills in half and take both halves at the same time and this makes it easier for me to get them down. My question - is this messing with the efficacy of the medicine?

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1
Vidalia68 Says:
Top Answer

You should not split the pills. They are an extended release tablet.

This is copied from the Contrave literature:

Extended-Release Tablets: 8 mg naltrexone HCl /90 mg bupropion HCl

CONTRAVE should be taken by mouth in the morning and in the evening. The tablets should not be cut, chewed, or crushed. Total daily doses greater than 32 mg/360 mg per day (two tablets twice daily) are not recommended. In clinical trials, CONTRAVE was administered with meals. However, CONTRAVE should not be taken with a high-fat meal because of a resulting significant increase in bupropion and naltrexone systemic exposure [see Warnings and Precautions (5.3) and Clinical Pharmacology (12.3)].

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2
Heather Says:

I am having the same issue, how did you do on them with them being cut in half?

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3
Mimi Says:

Re: Heather (# 3) Expand Referenced Message

I’m also having difficulty swallowing the pills while. I spent a lot of money on the medication don’t want to waste money.

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4
Kimbo Says:

Re: Mimi (# 3) Expand Referenced Message

Anyone cut the pills in half and had no ill effects? Like many of you, I start to gag trying to swallow them. They're much too expensive to toss.

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5
Dari Says:

Re: Kimbo (# 4) Expand Referenced Message

What kind of pills are these? And what are they used for?

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6
Kimbo Says:

Re: Dari (# 5) Expand Referenced Message

Weight loss medicine.

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