Sandoz Bupropion Sr 150 Mg - Same Medication, Different Manufacturer

Nicki Says:

Has anyone had a problem when having to switch their medication to another manufacturer? For the past 4 months I have SUCCESSFULLY been taking Bupropion SR 150 Mg manufactured by Mylan, sold by CVS (it is a light green round pill).....Unfortunately, my insurance recently forced me to go through Medco mail order and I received dark purple round pills manufactured by SANDOZ. Since taking these purple pills I have become sick daily. I have been experienced nausea, not seeing clearly (double vision or something weird like that), vertigo, motionsickness, extreme temperature fluctuations, not being able to concentrate, etc, etc, etc..... So I immediately switched back to purchasing this medication from CVS (Mylan) and my nasty symptoms disipated quickly and I am back to "me" again! My insurance will only cover me through mail order so I am forced to come out of my pocket.... Has anyone else had a problem with those little purple nightmares?

12 Replies

Earliest Newest Votes
Verwon Says:

Hello, Nicki! How are you?

Yes, there are others that have posted about experiencing similar problems with some generics, not necessarily the same one as you, but it does happen. I've experienced it myself with some medications.

It can happen due to some slight fluctuations in the active ingredient or differences in the inactive ones.

You could try asking your doctor to prescribe it as the brand being necessary, then the mail order place can't send you any random generic they have.

Is there anything else I can help with?

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Turtle Wins Says:

I know it's been months since this post but I hope I can shed some new light. I went to a different pharmacy to fill my latest prescription of bupropion SR 150. The previous generic was pale yellow, but the new pharmacy gave me purple pills made by Sandoz. These purple pills have a waxy, glossy coating on them that the other pills didn't. Within 5 days my depression got worse than it's been in years. Called my doctor who explained that the wax coating was probably not dissolving quickly enough and therefore I wasn't getting the dosage I needed. I switched back to the non-coated generics and everything went back to "normal" within a few days.

So yes, the difference between generics can be dramatic depending on the inactive ingredients. As my doc explained, the uncoated pills use a different sustained release mechanism than Sandoz, which apparently uses the wax coating as their sustained release mechanism.

Needless to say, I will be extremely cautious in the future when buying generic drugs.

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melanie Says:

I have had a problem in the past switching from Sanders appropriate to another generic brand and once I switch back to send us always good game. Recently the last few months I felt once again it’s like my meds aren’t working and was wondering if anyone knows if send us has changed anything and it’s in active ingredients

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melanie Says:

Does anyone know if sandoz has changed any active or inactive ingredients in bupropion sr recently ?

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Anxious Annie Says:

Hi, I've been successfully taking 150 mg SR for a year. The sandoz brand does well with me. I take it 2x s day. Why don't I just take 300 mg XL ? Tried all generics of this. They either don't work (get withdrawals), or side affects to include hallucinations. I also take 2 other anti dep. Spacing them out throughout the day works pretty well. My dep is severe, spacing them throughout the day is s real pain, but I'll do anything that works

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Anxious Annie Says:

Can't find generic Wellbutrin by Sandoz, 150 mg SR (bupropion). Can't take Solco generic that pharmacies have switched to, probably cheapest!

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Suzie Says:

Re: Anxious Annie (# 6) Expand Referenced Message

My pharmacy said they can’t get the Sandoz SR 150 mg anymore also. I looked on the Sandoz website and can’t find li listed. It used to be listed there

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Anxious Annie Says:

Re: Suzie (# 7) Expand Referenced Message

True Sandoz is no longer available. I've tried to source it numerous places over past 6 mos. I can't get a proper answer as to why, can't even be ordered by pharmacy. I'm taking the 150 mg generic buproprion made by Slate Run & it seems to be fine. It's a bit hard to tell with me because my depression is always lurking nearby. Pharmacy should be able to order Slate Run, it's made in China.

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Suzie Says:

Re: Anxious Annie (# 8) Expand Referenced Message

I called Sandoz and they told it was taken over by Epic Pharma. I talked to Epic Pharma and the assured me theirs is the same. My pharmacist told me the same thing. I just got the refill of Epic Pharma and compared the pill to the Sandoz pill. They look exactly identical. I’m hoping they truly are because none of the other generics worked for me. Your pharmacy should be able to order it. My Walgreens has it now.

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Nicole Says:

Re: Suzie (# 7) Expand Referenced Message

Hi Suzie, I know, it's so frustrating, I've tried many other generics and Sandoz is the only one that works. My pharmacist looked on their website and supposedly they won't be producing Bupropion again until May 2023. It's a struggle trying to find another generic form and a pharmacy which carries it, that's equivalent and isn't one I've already tried and haven't done well on. I've tried Teva, Par, Solco. All are horrible for me.

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Anxious Annie Says:

Hi, yes this is the pits when generic drug companies change ownership. I've had this happen with several of my meds many times. You're doing the right thing to buy the one that works, at least temporarily. You can try other pharmacies & see if they still have the Mylan left in stock for upcoming months & then next Jan you can see if the Epic will work. They all seem to be purple like the original name brand. I'm using the slate run generic & I don't usually take meds from China but so far for 8 mos it seems to work. I use a small pharmacy in a medical building because they work with me well, never have to wait & they order my generic. All my other meds are at Walgreens but they are so busy they sometimes can't accommodate me. Best of luck

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Pat Says:

Re: Suzie (# 9) Expand Referenced Message

I was on Solco brand Wellebutrin SR 150 12 hr. I wenf to Fl. they refilled prescription with Epic 415
Purple pill. The bottle says same thing as my previous med however when you look Epic
E415 up it is XL. I can not take XL
seems pharmacy or Epic is
trying to pass pill off as same as SR, it is not

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