Re: Dr Joey (# 3)
Dec 6 2012 Follow-up October of 2017
Reference your post back in the year 2012. Yes, I have had lifelong insomnia since the early 1970's. and, yes, as a general statement, the most potent, sleeping pills as mentioned in your post, are either no longer on the market, such as, Placidyl by Abbott Labs, removed in the year 1999. There is no other country either to procure this C-IV refillable in USA medication per the prestige Martindale, that covers 43 countries of the modern industrialized world. ISBN 978 0 85711 129 5
Also, Glutethimide, formerly known as "Doriden" made by Ciba.... USV, later, by Rorer, from the late 1950's/early 1960's until the first quarter of 1993, was, discontinued in the USA, when Rorer was merged with Rhone-Poulenc Rorer, especially because our DEA, reclassified, the Doriden from a Schedule III, for decades, to a C-II, in November of 1991, thus cutting into, a consistent but fast rise in sales of Doriden in the late 1980's thru 1991.
Doriden was especially highly prescribed in the NE corridor from Maryland up to the Boston area, when it was suddenly pulled off the market. Most C-III newly reclassified C-II meds, historically receive a drop off in sales when this happens, rather, when any med is upgraded into a tighter DEA class. Doriden I liked, but the drug was abused by a significant minority of recreational abusers, that, caused the DEA to reclassify this really very old sedative, due to a few rotten apples, ruining it for the majority by combining the top selling Tylenol #4 that is APAP 325mg and 60 mg of Codeine plus a 500 mg of Doriden tablet, causing a rise in DAWN reports to ER rooms in the USA, due to the alleged heroin type of a euphoria, the drug abusers sought.
Doriden, was made in Eastern Europe under two different manufacturers until the end of the year 2006, (Egan and Terapia of Hungary and Romania), but, was pulled off of the market shelves by the year 2007, a full ten years ago !!! It was called tardyl and glutimide, in those eastern european countries.
Methaqualone was last made in Spain (2000/2001) and in Switzerland in 2007.
Seconal and Tuinal (formerly the gold standard along with now deleted capsule preparation of Nembutal by Abbott Labs) the former two drugs was sold to first, Ranbaxy, by Eli Lilly & Son,and has been a orphan drug ever since, it is still manufactured, but only in a 100 mg capsules, of each, and, IMHO, it is the tightest, meaning the most elusive, and very (now) expensive sedative to locate.
It is primarily, only prescribed for hospice, or for end of life issue patients, including some state prison systems, such as the state of Texas, and, such as the state of Oregon, which has, for those with terminal illiness or, a desire for a self assisted suicide for only Oregon residents who meet strict criteria, the sole manufacturer, has those two states as leading states that use the Seconal and Tuinal, among perhaps others. The new generation of much softer hypnotics, in the 1980's, practically caused all barbs, instant release, to not be prescribed any more, even with a DEA licensed Psychiatrist. Chloral Hydrate was available until very recently, as Somnote, a C-IV, but is rarely prescribed, like, the outrageously expensive, GHB, liquid, known as Xyrem by Jazz Pharmaceutical, a C-III, with unusually very tight restrictions, "more trouble than it is worth to me" Sodium Oxybate was effective for me for only about 2 hours, then I had to redose, carefully, as the therapeutic window is very narrow, from, taking too many spoonfuls, of this over glamorized drug, again, by the media, it used to be available in Austria, San Remo and the UK for $75.00 US per bottle as "Alcover" in 1990's, but since around 2003 it has been a C-III and runs about US $750.00 and a US 1,200.00 sleep study to get it!
New generation of meds to initially replace, Nembutal, sodium Amytal, Sodium Secobarbital, and the combo product, Tuinal were the following:
All forms of Methaqualone, rose to instant national popularity, from their first introduction in 1965, that, by the year 1972, Methaqualone, had risen to the #6 top selling tranquilizer, sedative, or hypnotic, (non barb), across the entire top 200 of all ethical pharmaceuticals with the exception of the #1 top seller in the year 1972, Roche Valium !!!
Examples: from 1972: of Methaqualone a non controlled substance, a/k/a ,,,a Schedule VI. with PRN refills allowed in my case I only needed a once a year visit to my University Psychiatrist, who would write me 100 tabs take one or two tabs per evening as needed and PRN on the refills, in my case I refilled my methaqualone 300 mg tablets about every 90 days, that was the initial RX plus three refills or even 4 refills within one calendar year.
Examples for the year 1972, 1973, 1974, 1975. Methqualone hci.
Optimil (Wallace Pharma) Parest (Parke Davis) offered even a 400 mg capsule upgrade Somnafac (Cooper Pharma) Somnafac (Fourte)
Methaqualone (not in the hci formulation) was the top selling of all versions called "Quaalude" by William H Rorer in 150 mg and 300 mg tablets embossed with the 300 mg tabs the famous "Rorer 714" After Oct 1978 mfg by Lemmon Pharma,
Sopor, the 2nd most popular, in the year 1972, behind, the tradename Quaalude, by Arnar Stone.
A combination stimulant with methaqualone was also offered by Pennwalt called Biphetamine-T which the "T" stood with Biphetamine with Tuazole, which was the patented name for methaqualone for Pennwalt Pharma.
The immense success of Methaqualone, and, was short lived, due to the DEA reclassifying all versions of methaqualone on July 1 of 1973 into a Schedule II by the year 1978, Methaqualone had been reduced, from a very high sales of prescriptions, to only 3 manufacturers, Rorer, Arnar Stone, and Parke Davis.
The drug got heavily abused, and due to that, the state of Florida and Oregon made Methaqualone a Schedule !, the DEA followed up with a C-I beginning in January of 1984.
Placidyl a Schedule IV, always, and, Doriden a Class III, Noludar a class III, gradually replaced, the robust sales of Nembutal, Seconal, and Tuinal, by the mid 1970's, as well as sodium Amytal, which the latter 4 barbs, were classified from a refillable C-III, to a C-II, when the Bureau of Narcotics and DDrugs, formed in 1970, passed multiple laws classifying drugs with addiction potential with a January 1 1972 ruling placing most amphetamines, into a C-II class, and more sedatives (Barbs) were classified, into a C-II with more laws passed in July of 1973, including a newly formed DEA, that banned the production of combination stimulants with a sedative in one pill or capsule, later, more laws the most controversial law was the re-classifying of top selling Roche Valium, from a non controlled substance, in many states a C-VI, allowing PRN refills, to a Fed law beginning July 1 of 1975 placing Roche Valium as a C-IV, along with other benzo's of the time such as Roche Librium. + all newer to come more benzo's like 1980's Xanax, and, Restoril, Ativan, etc, etc, etc.
Dexamyl was a exception, that survived until, the year 1982 when SKF, removed this diet pill combined dextroamphetamine with Amobarbital from the market.
A rarely prescribed barb, that is a refillable C-III that is still produced in the USA is the barbiturate Butisol !!! (Butabarbital sodium) made by Meda Pharmaceuticals of Middlesex New Jersey USA. It is offered in a 30 mg tab NDC 00037-0113-60 and a 50mg tab NDC 0037-0114-60, by Brand Name.
I only mention this to those with hard core lifetime insomnia, who may be those reading this post who miss the much stronger sedatives of the (now) long ago past. Butisol is not inexpensive, it has a FDA Orange Book rating of a very rare AA class in quality, and the average wholesale price about 5 years ago was in US dollars was #100 $245.71 and may not be on one's insurance formulary as it is not commonly prescribed anymore, but has been around for 40 or 50 years.
Butisol Sodium also comes in a liquid Elixyr, of 473 ml. bottle with 5 ml equals to 30 mg of Butisol Sodium, It is classified as a "intermediate acting barb" not a immediate acting barb such as Seconal, (Secobarbital Sodium) or Nembutal, (Sodium Pentobarbital). Thus for the softer DEA scheduling.
I have tried even (short term antipsychotics such as Seroquel, and no way, can I deal with the sedative overkill, of that popular anti-psychotic with heavy sedating effects and very powerful next day hangover !!! Traveling abroad, I have even taken, the benzodiazepine, flunitrazepam, 1 mg, and I was most cautious with my 30 pill Rx of one mg, and, it was similar to me to 4 x 0.25 mg of Pfizer Halcion, and was "not the knock out date rape drug the USA press claimed to be for me" likely due to my high tolerance to sedatives and benzo's, I needed, to redose in middle of the evening with 2 x 1 mg of Flunitrazepam (Roche Rohypnol, for a total of 4 tabs per evening for a restful sleep (More trouble than it was worth, out of USA, with a face to face hotel referred MD.) It is sparingly prescribed worldwide, due to the stigma due to USA abuse of this benzo, illegally imported into the USA in the 1990's, from Mexico.
It is a real shame that other countries of the modern industrialized world never produced Abbott Placidyl, (ethchlorvynol) which at one time came in the USA in 4 sizes, 100mg, 200mg, 500mg and 750 mg !!! A generic company may have offered Ethchlorvynoi for one year around the year 1999 or the year 2000, but the sales of Placidyl had been declining for many years, from their heyday, in the 1970's, due to the perception that the safer meds such as, the immensely popular USA Ambien, took over sales, from the short term leader Upjohn Halcion, (Triazolam) that IMHO media negative press, caused the sales to "nosedive" harshly, in the early 1990's. former President Bush Sr once was alleged to take Halcion when it was so popular in the late 1980's.
Believe me, I have sampled nearly all of the "new age safer hypnotics" for my chronic insomnia, including 17 years use of titrating Sanofi Ambien (Stillnox), generic is Zolpidem tartrate, Lunestra, Dalmane, Restoril, lots and lots of Pfizer Halcion, and even ten years of my awful experience with the off label prescribing of the antidepressent Trazodone for my insomnia, I did not like due to the next day side effects and, it contributing by a panel of dental surgeons, to my Periodontal Disease, as Trazodone is very popularly prescribed because it it not a DEA controlled substance, and has strong sedating properties, and side effects, like dry mouth and a punch drunk non euphoric hangover very AM.
For me, this is just one opinion not advice by no means due to tolerance issues with decades of use of formerly effective drugs no longer available or affordable anymore, a dose of one Butisol 30 mg with one Restoril, 30 mg capsule, taken at bedtime, is the best sedative, I can work with in "today's world". The Restoril I have built up a tolerance to and alone does not put me to sleep nor does any more of the "Z" hypnotics, like Zolpidem or Zolpiclone, (Europe) or Eszopiclone "Lunesta".