Pazopanib Votrient

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My husband has been pazopanib for one week. The side effects are, loss of appetite, blisters on his tongue, and fatigue. Does it get better the longer you are on it? Does your body adjust? Or is this how his life is going to be? I have lots of questions for someone who has been on Pazopanib, and would love to talk to someone.

{edited for privacy}

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1

My husband has been on it for about 2 weeks and he's having the same side effects so I would also like to know that answer to this question.

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2

These are listed by the FDA as normal side effects of this medication. Unfortunately, most cancer medications are very harsh and such side effects rarely go away, but tend to continue for the duration of treatment.

Other side effects, may also include hypertension, diarrhea, vomiting, insomnia and tumor pain.

Is there anything else I can help with?

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3

I was on Pazopanib for 6 months before it stopped working, I had mouth and throat ulcers, loss of appetite, hair turned white, skin lost its colour and an upset stomach. The side effects seemed to come in waves. I was taken off pazopanib for three days to try and let my mouth heal. This had no effect. Later I was taken off them again but this time for 10 days and I was told when I go back on them my side effects should be less than before. Sadly before I could go back on them a scan showed my cancer had increased. I'm now on Nivolumab, it's an immunotherapy drug and my hair has come back black, my ulcers have cleared, my skin colour has improved but more importantly my weight has increased. I've been on nivolumab for 11 weeks now and NO side effects, yipee. Hope this helps, god bless and good luck, Des.

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Re: Des (# 3) Expand Referenced Message

I am 64 year old male March 2017 found tumor in left kidney. Had removed path said all rcc in tumor. Jan 2018 was having trouble breathing, went to family doc. Got X-ray showed a large pleural effusion,
Did thorentisis got 1.8 liter of fluid. Admitted did lung biopsy found 3 small rcc tumors. Went to oncologist . Over six week period drained 11
liters. Had pleurx catheter placed. Started Voltrient three weeks ago.
I take 800 mg at 7:00 am with 10 to 12 oz water. Eat one hour later.
No major side effects to date, some constipation but take half dose of miralax keeps me good can feel heart beat when in bed. Bp 135/84

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