Oxycodone Liquid And Tablet Administration

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Jake Says:

I have a small bottle of oxycodone concentrate liquid and I take three 30 mg tablets at once, 3 or 4 times a day. So I have a high tolerance and I'm trying to figure out how much I can take of the liquid to be safe? How long does it take for oxycodone liquid to work?

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1
Roy Says:

You would need to do a conversion to determine the amount of Oxycodone per ml of liquid solution. Typical concentrations are either 20mg per ml of liquid, or 5mg per 5ml of liquid (per this site's dosage list on the Oxycodone page). So first off, is the concentration listed on the bottle? If so then you would need to measure out the appropriate amount of liquid by doing a conversion.

For example, if your body is used to a 60 mg dose of tablets (which is very high, by the way), then the goal would be to take the correct amount of solution to get 60 mg of the active ingredient. In the case of a standard 20mg/ml solution, that would end up being 3 ml of liquid (60 mg = 20 mg * 3 = 3 ml). But of course, the rate at which the body absorbs liquid vs tablet also differs so you would need to factor that in. Always read through the instructions provided with your prescription just to be sure, and when it doubt double check with your doctor or pharmacist. It is easy to accidentally take the wrong amount of liquid so you need to be very careful! Anyways, I hope this helps and please write back with any other details or questions.

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2
Wendy Says:

Hello, I live in PA and my dr is telling me she can't prescribe more than 350 ml of oxycodone per month. This is not enough to give me good relief for a month. I need 15 ml per dose to get good relief. Is this a large or small dose? I've heard that taking Benadryl, Atarax or Tylenol can increase the effectiveness of the oxycodone, is this true? I have gastroparesis and a traumatic brain injury. Should I request something to compliment or replace the oxycodone?

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3
Wendy Says:

Hey, anyone out there? I have been taking the liquid with the 5/5 ratio. If I take 10ml, it usually kicks in in about 10-15 minutes for me. Is that a high dose? I'm concerned about all the addiction advertisements on tv!

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4
Roy Says:

Hi Wendy, sorry to hear about your pain troubles. Well, the 5mg/5ml ratio is on the lower end of what I'm seeing as far as liquid dose Oxycodone goes. I was looking at this site's NDC Database list for Oxycodone Solution. So, if you're taking 10ml it sounds like you are ultimately on a 10mg dose. How many times per day if I may ask?

If you are being capped off at 350 ml per month, then that's 35 doses, or an average of just over one dose per day. And yes, Oxycodone is often combined in tablets with another pain relieving ingredient such as Acetaminophen (APAP) - the brand name of this is Percocet.

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5
Wendy Says:

Re: Roy (# 4) Expand Referenced Message

I am allowed to take 5/ml every 4-6 hours. My new bottle will be 900ml. I guess since I was new at their office and they don't prescribe opioids, maybe they were kinda testing me to see how I handled the first bottle maybe? She also said I could do 10 ml if it was a really bad day, but that would me not as many doses out of the bottle. This stuff makes me pretty sleepy though, so I'll try a 5ml dose and see if it doesn't make me as tired as 10ml does. If it does, it's a bummer because she didn't suggest anything else we could try that is in liquid or IV form. What do you think?

The one thing that consistently gives me trouble is this insane itching on my face, neck and shoulders! I'm going bonkers right now! I've taken so much Benadryl tonight it's crazy! What does everything else do for itching, I mean even my lips and inside my nose itches.....help!!!

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6
Roy Says:

Ok, so it sounds like your doctor is comfortable enough giving you about 45 days worth of your medicine, which is good (factoring in about 4 x 5ml doses per day). Unfortunately the itching is listed as one of the Oxycodone side effects. Did your Dr suggest the Benadryl for that, or did you start taking it on your own? Just make sure that you don't develop a rash or difficulty breathing, as those may indicate an allergic reaction. I believe that Morphine also comes in a liquid form if continuing on Oxycodone for too long is a concern. Then again, that's just substituting one opioid for another.

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7
Wendy Says:

Re: Roy (# 6) Expand Referenced Message

Hi. Yes, she recommended liquid Benadryl. Now, most liquid Benadryl is children's. But we found an adult liquid Benadryl, but after reading the labels, it looks like the same as children's, you just take more of it. Can the dr ever prescribe the Benadryl and would it be a bigger bottle or cost less than buying the children's OTC Benadryl? Do doctors ever give Benadryl IV for at home use? There is another med she prescribed in tablet form and is 25 mg, but I can't recall the name of it....aterax maybe or hydro something? Is that more effective than Benadryl even though it's in pill form? Thanks so much for sharing your knowledge, it's so helpful!

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8
Roy Says:

Re: Wendy (# 7) Expand Referenced Message

I've personally not heard of a prescription or hospital strength Benadryl (Diphenhydramine). That would probably make someone very sleepy anyways. As far as the other med goes, I think you are referring to Atarax (Hydroxyzine), which does come in a 25mg tablet (NDC 0049-5610).

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9
Wendy Says:

Re: Roy (# 4) Expand Referenced Message

Hey, I looked at that oxycodone page. I hadn't really thought about different manufacturers. The oxy I got at the hospital pharmacy was thicker and had a much different taste and I thought I was just dreaming, but I thought that I could actually take less of the medication and it was more effective and didn't make me itchy. The stuff I've been getting at the local cvs is a much thinner liquid and tastes different, and I need 10ml to be effective... Could the manufacturers make that big of a difference for me?

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10
Roy Says:

Re: Wendy (# 9) Expand Referenced Message

Hmmm, if you're taking the same active ingredient and dosage (5mg/5ml) then coming from different manufacturers technically should not make a big difference. Although I've read other anecdotal reports from people on this site saying that their medication stopped being as effective when the pharmacy switched manufactures on them. Is it possible that the dosage you were given at the hospital was a different concentration? Or, could it also be possible that your body has become more used to the medication?

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11
Wendy Says:

How quickly can one become addicted to oxy? I'm so afraid that I will become addicted to this stuff!

Will insurance pay for the kind of oxy that has Tylenol in it? Just wondering because I've been taking Tylenol when I take oxy because I heard it helps make the oxy more effective. I'd need to take it in liquid or IV form because of my gastroparesis.

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12
Roy Says:

I believe that the body's physical dependence to opioid medications begins after a couple weeks of regular use. I say this because a friend of mine broke his arm and was prescribed Vicodin (containing Hydrocodone). He took the medication every day for about 2 weeks straight, and he told me that after he stopped the meds, the pain actually got worse. When he asked his doctor why his arm wasn't healing, his Dr basically said "Oh, your arm is healing alright, but now your body is creating the pain in order to get more of the medication." Addiction and dependence are 2 separate things and often confused IMO.

As far as a combination drug containing both Oxycodone and Acetaminophen, the most commonly known brand is Percocet, but that only comes in tablet form. For a liquid solution containing those ingredients, the brand name is listed as Roxicet (oral solution, NDC 0054-3686, containing Oxy 5 mg + APAP 325 mg per 5 ml). I am just going off the NDC database, so I don't know if it is available in generic form, or if it's even given to patients outside of a hospital setting. Can you let me know what your doctor says about Roxicet?

Whether insurance covers it or not depends on the specific policy, and of course if a generic is available, that should be considerably less expensive than the brand.

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13
Wendy Says:

Re: Roy (# 12) Expand Referenced Message

You are correct. When my prescription was filled in the big city hospital pharmacy, it was still 5/5 ml, but it was labeled Roxycet. Now my bottles from the local cvs say oxycodone and it's still liquid. The Roxy definately worked better for me and lasted longer even though it had the same numbers. What would you suggest I do? Does insurance control if I get the generic version of Roxy? Cause it's a shame if I need to take double the dosage of the generic and the relief is still not as good. What should I do? I'm being really careful about this whole opiod crack down going on, I don't want to ruffle my Drs feathers. When I made my first appointment with them they said that they don't even prescribe any opioids for new patients, but after meeting them, they brought up that I needed oxy and they have compassion for chronic pain patients and especially me, as I am new to the world of chronic pain in general. So they prescribed it for me. I just wish I could find a non opiod pain reliever for daytime so I don't get sleepy. I tried a lesser dose, but it didn't touch the pain. Any suggestions? Liquid or IV form works best for me due to digestion and absorbtion issues. Thank you!

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14
Roy Says:

Re: Wendy (# 13) Expand Referenced Message

I think that honesty would be the best policy here. I understand that you feel concerned about coming off the wrong way with your doctor, but if you were given the Roxicet in a hospital setting and it worked better for you at a lower dose than just the straight Oxycodone, then they may be open to switching you.

I don't believe insurance would dictate whether you get a brand or generic version of the drug (I believe it's up to the Dr or pharmacy), but insurance will definitely cover the drugs differently. If a generic version of Roxicet is available (anyone know?) it would likely be less expensive. Hope this helps!

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