Oxycodone/percocet Generics! Which Are Most Effective? (Page 7)

Updated

Hello,

First, let me start by saying that I am somewhat opiate naive. I am not in pain management and hopefully won't need to be. I've had scripts here and there for norco and percocet. It is the generic percocet, or more specifically the oxycodone, i'd like to discuss here.

Over the past year i've had issues (such as a broken elbow, recurring kidney stones, and a staghorn lodged in my renal pelvis [kidney]), that have lead to several prescriptions for percocet from a total of 4 different manufacturers. Mallinckrodt 10/325, Amneal 7/325, Rhodes Pharmacy 10/325, and AuroBindo 10/325.

I've read a lot of reviews about the aforementioned generic manufacturers. The majority of them have been negative especially for Rhodes. Mallinckrodt and AuroBindo are the only two that seem to have, at least, a couple of favourable reviews.

I've got a new script for a week's supply of percocet 10/325. The primary pharmacy that I go to is Kroger (my local CVS carry Rhodes). Kroger carries the U17 Aurobindo which seem to help with pain but cause other issues; tinnitus, anxiety, drowsiness, agitation and at times nausea. Those are things I can deal with but I'd rather not.

Does anyone have any input on what they find to be the best generic manufacturer of oxycodone? I've read about endocet, actavis, watson, kvk, and others but none of them seem to be readily available in my area.

These are what i've tried in order from best to worst:

1. Mallinckrodt - good pain relief, seemingly no side effects, mild euphoria. (Unfortunately I cannot find Mallinckrodt anywhere around my area.)

2. (tie) Amneal/Aurobindo - Kind of a toss up between these two. They seem to work for the pain but have noticeable side effects. Auro (effects listed above) and Amneal both seem to cause anxiety/panic. Profuse sweating and itching have also been experienced with Amneal although not with Auro.

3. Rhodes Pharmaceuticals - I've read some horrible reviews for these. While I don't think they're as bad as some of the reviews, they were definitely very weak compared to the others i've tried. Sort of hit and miss though as one pill would make me feel high and another would make me feel sick (while not doing much for the pain). A plethora of side effects with these as well with malaise and dysphoria; the ultimate worst!

Okay now that you've heard my subjective opinion and rant, can anyone out there offer their opinion on these generic oxycodone/percocet manufacturers. Are there any generic brands I'm missing or never heard of? What's the most effective for killing pain with the least side effects? (I'm taking them for pain).

P.S. I'm going to have to fill at Kroger and get the Auro U17 regardless but would like to know for future reference. Thanks in advance! I'm in the Indianapolis, Indiana area.

142 Replies (8 Pages)

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121

Re: Mandie (# 112) Expand Referenced Message

Look into the carnivore diet. It eliminates all inflammatory food from your diet and it causes your body to use medicines more efficiently because none of the drug, well next to almost none, is stored in fat cells.reason being your body now feeds on fat for energy instead of carbs"sugar"..

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122

ISE #101 & Annie #103 --

Annie, you are correct. Brand Name "Endocet" 10-325 (10 mg of oxycodone and 325 mg of acetaminophen was still available NDC # 60951-0712-70 tab were still available, as recently as 2017, they come in bottles of 100 tabs each, DEA class C-II. FDA Orange Book rating a "rare" AA, the "final step up", out of 17 different "lesser quality ratings" (actually 10 of the 17 FDA Orange Book classes are for quality control efficiency).

Endo Pharmaceuticals, Inc. (610) 558-9800 (Pennsylvania USA). the MAKER of the drug, (patent holder) not necessarily the SELLER of the drug, (some major big USA firms will "farm out" the proprietary drug, to a different mfg, to Endo standards, who actually mfg said drug, and, it's then offered to a drug wholesaler, with a DEA license, to market to USA pharmacies.

Source: REDBOOK (pharmacy's fundamental reference) edt 2017 121st year of publication, (now on the internet only) no longer published in textbook form, since the year 2010. "Endocet" brand name was listed as available also, in USA, Canada, and Israel, as well, (page 114) of the 38th edition of MARTINDALE (The Extra Pharmacopoeia) a/k/a "The Complete Drug Reference" info in 43 countries of the modern industrialized world, Pharmaceutical Press, London
UK, (ISBN 978-0-85711-139-5)

Endo Brand name Percodan was also still listed in the Martindale for USA citizens, but was discontinued for citizens of Canada. Endo has realized a significant increase in demand for USA C-II Opana and Opana ER brand name, directly due to the reformulation of Purdue Pharma "OxyContin" original formula, (1996 to 2010). Purdue OxyContin has realized a large decease in sales and a decrease in consumer satisfaction surveys, with their OxyContin "OP" embossment, vs. their "OC" embossment (old formula) of OxyContin (USA).

Opana (oxymorphone HCI). The pharmaceutical industry in the USA has changed radically in the past, 6 years, IMHO. Many reasons, Brand and Generic, the latter especially. It can be a daunting challenge to get a USA chain pharmacy to special order a prescription drug, written as DAW, due to, hostile rules and regulations, by corporate office, of many USA pharmacy chain drugstores. IMHO, the independent pharmacy, preferably an owner-operator, i.e. owner pharmacist, or a independent family pharmacy, that were once very common in USA, but, in the 21st century are a dwindling group of pharmacies. (depends on your geographic location), and other reasons, such, as many pharmacy/owner's retire, and, sell their pharmacy to a big USA chain pharmacy. In my 47 years of using both chain USA pharmacies vs, an independent pharmacy, I'd place my energy more in searching for a more co-operative, independent pharmacy especially run by a pharmacy owner. The downside, is, you may have to pay more money to get a special order drug, like, Endocet, if it is not normally on the stock shelves,due to low demand, (understandable) pharmacy needs to make a profit, to stay in business, and many Brand products often are very expensive I mean "very expensive"I know I have been there, like, 3 to 5 fold more pricey, and, of course, it is a small minority of USA insurance firms who will pay for an inflated price, so, only the "haves" in the USA can do this and the "have not's" (like me) have to take the leftovers, (often the generics) especially since the Obama Care Act was placed into law. I am not anti-generic necessarily, but, my attitude has changed in the past 6 to 8 yrs,
due to the greedy USA pharmaceutical companies. The truth is in the here and now the GENERICS vary greatly. yes the 80% to 120% FDA regulations are still in effect but,the bioavailability, (how our body metabolizes the fillers and binders), is what the generic USA mfg are manipulating that is the cause for "so many consumer complaints, in the past 6 years".

Bottom line, if you can afford it, you are good to go!, if, you cannot afford it, like the majority of USA citizens, you may have to take a far less efficent substitute, generic. FDA regulations, about Orange Book bioequivalence, is some help .....yes, but, the AA rated Orange Book meds I assure you are in the strong minority of drugs available. Also, the pharmacy MAKERS have the pharmaceutical sellers who sell the drug, and actually mfg the drug...well, often due to high pressure price point demands, the formula is modified, to lower quality standards, with more fillers & binders to meet the strict price point, or, the MAKER, will, not do any business with the drug SELLER, (actual mfg of the prescription only drug).

The Bio-availability is often overlooked by the USA consumer, which is NOT regulated by our lazy FDA. In the past 6 to 8 yrs, many drug ingredients, are purchased overseas, and, the USA drug manufacturers, they do their own self reports on the drug quality, and, many large USA drug MAKERS, often buy out smaller drug MAKERS, and, the quality can switch quickly, to increase profits, and, IMHO, gouge the public consumer, and/or, the drug MAKERS are very manipulative, and they often, own their own generic company, and/or switch or "farm out" a prescription drug, quickly, with a "merger", I have never seen so many mergers in my life as in the past 10 years!! JMHO. Source: FiercePharma and Bloomberg.

The only other choice, is not practical for many USA citizens, but, the brand names "across the pond" in Western and Eastern Europe, are, much less expensive, and, are very high quality, the problem is, two fold, one's mobility or ability to travel abroad, and, the USA laws that prohibit, the purchase of especially controlled substances, "by other means". I shall
plead the 5th amendment on what I define as "by other means".

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123

Re: Skip (# 121) Expand Referenced Message

Thank you so much for your response!! I had no idea about how the meds affect you internally, could you send me a link or a better explanation on how my diet will affect the way my pain meds Work? I’m very interested in anything to better my quality of life. Should I just look up carnivore diet? Thanks again for your response, I appreciate it very much!

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124

Re: ISE (# 111) Expand Referenced Message

I know Brittany Murphy didn’t die of drugs. She had pneumonia. I am legal to smoke and believe it or not THC makes my pain worse. I do like CBD, it is helping a lot, also with anxiety and depression. But it is sad how everyone is being punished who suffer from chronic pain, because of other people who like to abuse drugs! And pain meds! But I am all for pain medicine if you need it.

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125

Re: kdog57 (# 15) Expand Referenced Message

I think the best of them would be Actavis A 215 30 mg EPC. Duel agonist if you can find them. They work mainly through the MU receptor. The brand Roxycodone 30mg are about the same but cost way to much. No feeling of euphoria to speak of after the reformulation. Oh and the antagonist opiate blocker they say isn't there is. They need one or they would be very dangerous. But Naltrexone blocks all the euphoria. Look it up, "Naltrexone".

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126

What about Hydrocodone generic for vicodin? I think it has the least side effects except the fillers must bother me with an allergic reaction of itching me all over! Why can't something be done about this? I know of other people it happens to!

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Re: Mason (# 8) Expand Referenced Message

Reason being they all have been on the mild side for a couple months now. Normally they should help. Good luck.

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128

Been on Oxycodone and Percocet p!us a long acting narcotic for 20 years and in that timeframe have tried a lot of the generics.

It would seem to me that Activis and Watson worked the best but never received any meds that flat out didn't work.

That is until February of this year my Walgreens changed to Camber.

I was sick within hours of taking them.

Vomiting, terrible stomach pains (not cramps), awful pain and withdrawals thrown in there too.

I was shaking and just plain miserable between what the drug was doing to me and no pain relief at all.

Thought I had the flu til I just happened to see a post about lots of people being sick taking Camber.

Not sure what's in them but I truly felt poisoned.

After a week of misery, my PA at my pain clinic was kind enough to write me a script for hydrocodone to get me thru til I could get my next Percocet script.

They now order Activis for me.

It took me days of being off the Camber to really start feeling better.

From now on I will check any script and will never take anything from Camber again.

From what I have seen, it looks like there are problems with other meds they make.

I have tried to tell my story everywhere I can hoping to save some folks the agony I went thru.

Generics are absolutely not all the same.

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129

Re: Bravesfan (# 128) Expand Referenced Message

I agree with you!! Ive been trying to get this out to people too!! Generics are NOT effective!! They are filled with more inactive nasty fillers and MUCH LESS of the ingredient that makes it effective!! Im sick of what is happening to the medicine that is supposed to help us!! Ive had so many negative reactions to generics!! Itching, upset stomach, headaches, panic attacks flu-like feeling. There is a war on people with chronic pain because of the people who are abusing opiates!! Why should I suffer because of other people who cant control their actions!! Innocent people suffer because of the ones who abuse. Do the homework!! Check medical histories of people before you through them together with abusers!! There are a lot of us who take medicine responsibly!! Something needs to be done about the lousy quality of medicine being sold to us!! We need a loud voice who will help stop this nastiness of selling us poor quality medicines!!

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130

Re: ThunderHeart (# 129) Expand Referenced Message

I’ve always thought that the A.M.A., or whomever, would be absolutely sure that, for example, if you get any generic drug it would be mandatory that the exact amount of the active ingredient should be in all generics... I know people that take Diazepam & they insist that the “Roach Brand” is better than all of the many generics that are out there... Maybe it’s all in their heads like the Placebo effect... I don’t know, & how did you determine that there’s less of the active ingredient in the generics, are you a Chemist & tested these drugs you’re referring to!? Please explain ‘cause you can’t go by what someone or even many people tell you...You should have Hard evidence not just hearsay!

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131

I would advise getting a copy of your medical records from your pain clinic ..... i m going out of town so i asked for my records ...... i went back 6-7 months ,,,1 visit every 28 days ..... i cant even tell you how many mistakes i found from not so drastic as family member ailments that i have no idea where that info came from ????? To very serious lack of entering current symptoms ...... IMO THATS INEXCUSABLE SCREW-UP .......... how can dr make a good dicission without proper information ........i better stop here just get your records & make sure they are filled out properly

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132

All the ones you mentioned are terrible!! It took me a year of suffering with horrible side effects until I tried Endocet. No side effects and good pain relief. I’m on the 7.5/325 right now but will try the 10/325 down the road. Amneal has by far the most complaints with the FDA. Do your research (I’ve been researching for the last year after being given Amneal). I never realized that there was such a huge difference in generics before my bad experience. Horrible pain in my upper stomach for the full 30 days I was stuck with them and NO pain relief. This is true for ALL genetics, not just opiods. Most drugs nowdays are being manufactured in India and China. Who knows what they use for fillers!! Could be plastic. I WILL NOT ACCEPT ANY DRUGS THAT ARE MANUFACTURED IN THOSE COUNTRIES. Like I said ~ do your research. It’s time consuming but worth it.

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133

I'm reading these comparisons in a new light tonight. Percocet at one time was very effective. There were no generic drugs. Just brand name. They were used for post surgery and most severe pain caused by accidental injuries. The DEA.... is responsible for the reformulated oxycodone to stop drug liking. High doses weren't needed before this whole darn mess with abuse. If oxycodone was returned to it's original formulation you and many other people would not be suffering. This may not be a popular version of why they don't work but it's nothing but the truth!

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134

In my last post late last night I failed to complete my thoughts. When oxycodone was reformulated there reasons were to reduce drug liking and addiction. I believe this step was in response to the abuse problems. End result went too far by taking away some of the analgesic powers as well. All forms from brand to generic were affected by changing the main ingredient oxycodone. However this change that was in good faith left a problem. Mallinckrodt at that time made a superior product rated amongst the best. Actavis as well which is difficult to find, so no matter what you choice or what is available still include the same main ingredient. Other companies used an array of binders that don't agree with everyone. So your body chemistry dictates what will work for you. No two people will have the same effect is why there is so many different opinions. So now choosing is a difficult one. Many pharmacies make there choice based on cost, strength and what's best for there customer. When food becomes an issue its not about what you eat as it is when you eat. Hope you find something that will work for you and control your pain, that is what we are talking about!

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135

Re: David (# 7) Expand Referenced Message

Are you taking Rhodes they cause crazy Sciatic nerve pain

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Re: Sparky (# 11) Expand Referenced Message

Order kratom and capsule it. It actually works.

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137

IMHO stay away from CAMBER, pure poison.

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138

I'm now on 30mg oxycodone by Mallinckrodt manufacturer that make me very sick. Can anyone suggest a different manufacturer that is better?

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Re: Mason (# 1) Expand Referenced Message

I went with Mallencroft and they have been okay. Stay away from Camden.

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Re: Mason (# 6) Expand Referenced Message

stay away from camder they are junk

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