Metoprolol Withdrawal (Page 128)

i've been taking metoprolol for several years as partial treatment for high blood pressure. through diet and exercise, i've lowered my BP to the point my doctor says drop the metoprolol.

i did, 3 days ago, and i'm soooo tired, dizzy, irritable, and my vision is blurred.

is this withdrawal? how long will it last?

i remember starting this medication was terrible to get used to. it appears that stopping it is just as bad.

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Well, my SIBO turned into full blown Mast Cell Activation. Luckily I was able to get in with a functional medicine doctor who made the diagnosis and is now treating me. I’m still not stable, but hoping I’m at least on the right path now.
I wonder how many of us who struggled with metoprolol actual have underlying MCAS. With MCAS, people have a tendency to react to inactive ingredients in medications. Metoprolol can be extra problematic in that in can inhibit DAO which is the enzyme that breaks down histamine.
For me personally, I think the MCAS caused my initial tachycardia. Since the root cause was never identified, I was given metoprolol as a “bandaid” and that only made things worse.
Just wanted to share my story in hopes that it is helpful to others.

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Re: RV (# 2540)

I’m doing okay RV. How have you been?

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I’m currently weaning off corlanor and most days feeling pretty back to normal.

I just got over Covid :( but luckily for me it was very short lived and I was pretty much back to normal at about day 5.

Last night I did feel a little funky which I haven’t in a while and I don’t know if it’s because I’m weaning or maybe Covid or maybe just a random off day.

I just had an echo and all was perfect. I still have my loop recorder and that’s been all normal except the few cases of tachy here and there.

RV- did you ever figure out what was going on?

JULIYA are you doing better with your MCAS?

dang Cupcake. I know you said you were having tests done: are you feeling any better now that you know it’s MCAS?

Sometimes I wonder if hormones are at play: I might have them tested

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Re: Juliya (# 2542)

I am doing okay as well. One day at a time deficient/low in lot of vitamins i am wondering if metoprolol caused it or have some absorption issues. Back to old self?

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Re: TxCandy1 (# 2543)

Hey there! Had two emg’s they were clean. I still have occasional twitches and deficient/low level of vitamins so i am wondering if thats the cause. I am really glad you guys got better.

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Re: Cupcake922 (# 2541)

That's interesting about the metoprolol and histamine. I will have to read up on that. My genetic testing identified that I don't process histamine appropriately. I haven't been tested for MCAS but I have a suspicion. My Cardiologist just says I was super sensitive to it. My new EP can't tell me why I had such an awful reaction to metoprolol. I also had the same reaction to propranolol. So it seems like a beta blocker issue to me. I've now given in and taken Cardizem and it has been great so far on the days I've taken it!

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Re: Tinker (# 2546)

Did any of you take the boo ster? I did this Sunday and it feels like beta blocker ordeal all over again. Heart rate all over the place, adrenaline rushes, crazy feelings etc. I’m sooo upset this seems to be happening all over again and I don’t know what to do

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Re: Tinker (# 2546)

How do you get tested for MCAS? After this last jab I’m wondering if this is what I have now. I got the inn on Sunday and these are my symptoms

I’m on day 6 post. Day 3 was the worst. I have had crazy adrenaline, the shakes, intrusive thoughts, high jumps in HR all of a sudden, diarrhea, gagging at all foods, no appetite, and yesterday the top of my head and forehead felt like it’s burning.

After going through the beta blocker ordeal, I’m so bummed that this is basically starting over. I hope it doesn’t last as long as beta blocker ordeal. Is there anything I can do, so rehab faster?

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Re: Txcandy1 (# 2548)

I did not get the booster. I had a reaction to the first shot. My new electrophysiologist says I developed autonomic dysfunction from it. She does not know why I reacted so bad to metoprolol. But I did read that people with mcas have difficulty tolerating beta blockers. I had similar reaction to propranolol. I'm not sure the testing for mcas but I'm going to have alot of testing through my electrophysiologist who also does functional medicine so hopefully will get some more answers. I've been on a low histamine diet for 6 months now and I do much better on that. All of my issues started after the covid vaccine. And metoprolol made things worse. I've been dealing with issues for 14 months now. Things are slowly improving. I no longer have the adrenaline surges or high heart rates. That got better around 7 months after getting it and around 4 months after stopping metoprolol. I still have awful Pac's. I am now taking Cardizem on the bad days which has so far been great. I'm hopeful for more answers when I see my doc again next month.

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Re: Tinker (# 2549)

I will not be taking any more at all either. This week has been hell. I don’t know what testing to get done. What is your electrophysiologist testing? I might get a 3rd opinion EP cuz mine has been ignoring me pretty much. I’m pretty sure I had an SVT episode a couple weeks ago, and I caught it on my Apple Watch. I have a loop recorder and I asked the EP to check and all his tech said was you’re fine. I sent the Apple Watch strip to a cardiac nurse I know and my cousin who had SVT and they were like absolutely yes, but my EP says no? I don’t know what to believe. I also don’t know what kind of doctor to see after this booster ordeal! I leave the Country at the end of the week and I’m a tad nervous

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Re: RV (# 2545)

RV! How have you been? Better? Did you ever find out what was happening?

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Re: Txcandy1 (# 2550)

I don’t know why I did not see your last reply until now! I hope things have improved for you. Did you end up getting another opinion? I left my first cardiologist because he didn’t seem concerned about anything, not the fact my issues were at severe I was essentially bedridden and couldn’t work anymore, didn’t care I was having awful side effects from metoprolol and even wanted me to start taking it again???????. My EP is great. Although she is not concerned about my ectopic heart beats she does think I may have mcas. She says the testing for that isn’t great and must be performed during a flare. So we are treating as if I have it. Maybe that could be a reason I had terrible reactions to the medication. I will never get a for sure answer I’m afraid. I’ve been off of it for 15 months now aha still stuck with the awful ectopic heart beats although better than when I was taking it but they just haven’t gone away??. Cardizem helps though mostly.

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Re: RV (# 2544)

I became deficient in vitamin D and iron...and most likely vitamin B12 but haven't tested for that one. I really hope quitting this drug will help. I went from having tachycardia issues to having extreme limb fatigue and palpitations...I would rather just have a little faster heart rate.

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Re: RV (# 2382)

yes I get the exact same symptoms when standing up

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