Methothrexate & Leucovorin

I have had RA for 8 years I was taking methotrexate and leucovorin 12-16 hrs later.
Just started with new doctor and he changed me to folic acid he said leucovorin interfere with the methothrexate. I feel so much better it is hard to believe such a little change could make such a differents. So happy I made the change.

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Hello, Gail! How are you? I'm glad that you've got a combination that is working better for you.

However, there is nothing listing a problem between them, so I can only assume your doctor was going by experiences with other patients.

You should be aware, though, that the Folic Acid is listed as possibly interfering with the absorption of the Methotrexate.

Has anyone else faced similar issues?

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