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How long before you notice results from Melpaque? And how long do the results last? ## Hi Jessica, The administration guidelines for using this medication state that "your doctor will tell you how much to use and how often"...Because of this, results for each individual will vary greatly based on the application guidelines provided by their doctor. Alternatively, I tried looking this information up, but could only locate directions for applying the cream: "Melpaque should be applied to affected areas and rubbed in well twice daily, in the morning and before bedtime, or as directed by a physician. Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended." Based on the above info, ...1 REPLY Updated