Linzess Forums

Recently active Linzess forums and community discussion threads. Post your question or story about Linzess and connect with others who have experience with the same medications. No registration is required and your identity remains anonymous.

Popular Threads

Linzess weight gain 102 REPLIES
On Linzess for a week, NOT "Working" - HELP! 54 REPLIES
Linzess stopped working 32 REPLIES
Anybody else get hives after Linzess? 24 REPLIES
linzess prescribed to help with weight loss 24 REPLIES

Recently Active Discussions

Page:1Next PageLast Page
On Linzess for a week, NOT "Working" - HELP!

Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...

54 REPLIES Updated
Blood Sugar went up after Linzess

My morning readings have been below 140, but after taking Linzess they have been anywhere from 170 to 267. Does Linzess raise blood sugar? Anyone else have this issue?

Updated
Linzess not working for me

I was on Amitiza 24 mcg twice a day and Miralax was switched to Linzess 3 weeks ago. I am having so many issues, feeling lightheaded a couple hours after taking it in the morning and very bloated and have not had a normal BM. A few days without anything and then diarrhea. I think I am going to switch to before dinner and take Miralax before bed. What is the opinion? ## This medication should be taken in the morning, at least half an hour, before ingesting anything else. The Side effects that you've experienced are listed as being normal ones, according to the FDA, you may also experience nausea, and stomach pain. It is not as effective, if taken later in the day, after you've already eaten throughout the day, so it is best to follow the manufacturers instructions. Is there anyth...

3 REPLIES Updated
How long does it take for Linzess to get out of your system?

How long does it take for Linzess to be completely out of your system? ## How long does it take linzess to get out of your system? ## @ike / sandy, From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on NIH.gov, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes. [1] source: PubMed / PMC3638410 That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame. Hope this helps! ## How long does it take for linzess to get out of the body ## How l...

22 REPLIES Updated
Linzess not working

I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my belly rumble, then I have to push to get anything out and it's still hard. ## Hi I agree.The first week I was on linzess it work to well vut it still helped but now that im back on it its been two days and still nothing.. what did you do or why is it my stomach just rumbling but im not going. ## It should be taken as prescribed by your doctor, which is usually daily. Additionally, it needs to be taken with water, on an empty stomach, at least 30 minutes before eating or drinking anything else. The FDA lists its typical side effects as possibly including nausea, dizziness, abdominal cramping, bloating and diarrhea. Does anyone else have any advice or ideas that may he...

8 REPLIES Updated
New to Linzess for IBS-C

I have had IBS-C for over 35 YEARS having only one bowel movement every 6-7 days. Good thing I had my own bathroom in my office. When you do not have regular bms you forget the last time you went. I have to keep a calendar. My dr gave me a prescription for 72 mcg. It took a week to work and it totally emptied me out for hours. At the end it was just brown water coming out. Since then I have been going 4-5 days before having a complete emptying out with severe explosive diarrhea. I wondered if maybe I can empty the capsule out and only take part of the med a day? Yes it is good to go but when you have to put diaper rash cream on you because it is so explosive I kind of wonder. I guess it is better than not going. Also has anyone before Linzess had bad stomach aches because you did not go...

2 REPLIES Updated
Linzess and low sodium

A warning: Took 145 for 3 days and ended up with a 2 litre min BM of mostly water plus dehydration and low sodium levels on day 4. ## Unfortunately, that is a possible side effect, it works too well for some people that take it. The FDA lists its other side effects as possibly including nausea, stomach pain, headache, and bloating. Ref: Linzess Information How are you feeling, now? Have things improved?

1 REPLY Updated
Anybody else get hives after Linzess?

Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared about half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...

24 REPLIES Updated
linzess prescribed to help with weight loss

Hi! My Dr. Gave me linzess to help with weight loss. HOWEVER, I am reading all the posts about horrible weight gain, I am confused!!!!!!! ## Hello, Twinckle! How are you? This medication isn't intended to be used for weight loss, it's actually used to treat chronic constipation. It can cause diarrhea, which could result in weight loss for some, as reported by the FDA, but it can also cause abdominal bloating and distention, which has caused many to think they were gaining weight on it. Can anyone that's been on it chime in with their experiences? ## Hello, Linzess can certainly be prescribed for the purpose of weight loss! People do not understand how medications can treat multiple...repeat MULTIPLE conditions, diseases and illnesses. Botox is FDA approved to also treat head...

24 REPLIES Updated
Taking Linzess with food

I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she will call in the higher dose. Took this morning before bed. (I work nights 7p-7a) I have had stomach pain all day. I haven't been able to sleep or get comfortable. I've had rumbling in my stomach, gas and an extremely hungry feeling with the 145mcg dose but no pain. It's been 8 hours since I took the 290mcg dose. I just ate something and I feel a little better. I read that I should take Linzess 30 minutes before eating but I usually don't eat until I get up in the afternoon. Could this pain be a result of not eating with the higher dose? ## Hi Krischris1, Sorry to hear about your situation. According to the manufacturer, you are right that it is recommend...

12 REPLIES Updated
Linzess weight gain

I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...

102 REPLIES Updated
Excessive Bloating on Linzess

I've been on Linzess for about a week now and the bloating is unbearable. The medication has produced several BM's and I had severe diarrhea the first two days on the medication. The diarrhea has subsided but the bloating continues to get worse. I is painful and it looks like I am 6 months pregnant. My clothes don't fit anymore and I can't find any helpful solutions to the distention. Has anyone had these similar symptoms and do they typically go away? ## Hello, Kristy! How are you? I'm sorry about the problem you're having. Yes, that has been reported by many people and is a known side effect as listed by the FDA. You may also experience weight changes, nausea and dizziness. Can anyone that's taken in chime in on whether or not it's gone away as your bod...

4 REPLIES Updated
Hi newly prescibed linzess , taking for 2 days with no bm

Just prescribed linzess by my pcp , took it for 2 days with no results . My doctor directed me to take only when needed! Which contradicted the prescribing info! I have had problems for over 20 years , have tried everything and still no luck! Any suggestions would be appreciated! ## Hi Jill, I was diagnosed with Colonic Inertia and I am unable to have a bowel movement on my own. I started with the low dose of Linzess and it did nothing. Then my Gastroenterologist ordered the higher dose and I could not stay off the commode as the diarrhea was terrible. I am now back on the low dose and it seems to be causing severe diarrhea. I would give it more time and see what happens. If I do not take it I become so bloated and have a lot of flatus and nausea. You can also try Phillips MOM at night....

3 REPLIES Updated
Linzess stopped working

I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...

32 REPLIES Updated
linzess weight loss

how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss, so there is no time frame I can give you for this. It is used to treat symptoms of IBS that are associated with constipation. And while that may cause weight loss, in some instances, it can be dangerous to try to lose weight via giving yourself diarrhea, since it creates the risk of malnourishment and dehydration. Common side effects to this drug may include nausea, dizziness and stomach pain. Was it prescribed for weight loss? ## I just received a sample from the dr to help with my weight loss, however, I am shocked at ALL the side affects from people of.horrible weight gain! I am confused, can you please help explain? ## I have IBS. Been taking linzesss for a month....

9 REPLIES Updated
Linzess or other Drugs blocking weight loss

I eat very clean, rarely at restaurants. I have been on Linzess (Lazy bowels) for years, been on synthroid (subclinical hypothyroidism) for several months now along with simvastatin for high cholesterol (hereditary). All blood work shows perfect numbers. I have done several variations with my macros monitored by a trainer. I have not been able to drop any weight in 3 years. No one understands, not even the doctors. I am a personal trainer my self and work out 5-6 days a week. I’m about to stop all prescribed meds because I don’t know if they may be causing the issue. I feel like I’ve been beating my head against a brick wall! Any suggestions? ## Synthroid has been known to cause increased appetite, but both the Linzess, and the Simvastatin are known to cause weight los...

2 REPLIES Updated
controlled constipation relief

I'm a stroke survivor who, post stroke, suffers from extremely irregular bowel movements sometimes going 5 days without a BM, I don't have pain or bloating, I do suffer from acne breakouts ocassionally which is kinda embarrassing for a man in his 50's. Testing provided a diagnosis of 'slow motility', i.e. part of my brain injury from the stroke affected the function of my digestive system) I was prescribed Linzess 290 mcgm daily to address this problem and to restore BM regularity. I only take the medication on Mondays and Fridays as i work from home on those days and my home office is next door to the toilet, otherwise I run the risk of a bowel evacuation at the office which would be humiliating. I take the medication on an empty stomach with a 12oz glass of water a...

2 REPLIES Updated
how long after you take linzess to work

The 290 gave me severe diarrhea and cramps but lower soaw no bm I tried waiting a day then take again had horrible round hard stool a few of them passed only with manipulation and bleeding so I took same day the 290 and nothing but can feel it there making it difficult to sit or walk. ## I'm sorry, perhaps I am not understanding you. You said you did not have a BM, but also say it gave you severe diarrhea, and diarrhea is having a BM, even though it is runny and likely not your usual consistency. Can you please clarify? Did you make sure to take it correctly, which is a half hour, before eating, or drinking anything else? Diarrhea can be a normal side effect of Linzess, along with nausea, cramping, and flatulence.

1 REPLY Updated
New Insuance denied my Linzess RX B/C I don't have cancer!

I have been on Linzess for over a year now, and happy enough with the results. I had been covered through Blue Cross/Blue Shield of NC. There was NO problem getting the rx filled. Now I am covered through BC/BS of Minnesota. I received a letter denying the rx stating that I am not eligible because I don't suffer from active cancer pain! What the heck are they talking about?!?! Has anyone else run into this kind of issue with their insurance?? ## Appeal it and they might. Your doctor may have to do a prior auth, but I would fight it. I have before with other meds and other insurance and it works. ## Thanks for your reply. Unfortunately I have already appealed and I have still been denied. ## That is very odd, since Linzess is used to treat IBS with constipation, and idiopathic chroni...

3 REPLIES Updated
72 mg Linzess experiences

Anyone taking the 72mg dose of Linzess, and what are your experiences with it? I just filled the prescription and want to try, just worried. Thanks. ## Hello Drew, According to the NIH linzess has the following adverse reactions. For all of these only 10% of users experienced these symptoms. - Diarrhea - Abdominal pain - Flatulence - Abdominal distension - Viral Gastroenteritis - Headache It's smart and understandable to be cautious when taking new medications. If you feel that any of your symptoms are out of the ordinary or too severe for you to handle please consult your doctor as you may be having an allergic reaction. Have a wonderful day and I hope this helps.

1 REPLY Updated
Page:1Next PageLast Page