Linzess Not Working As Well

Kaye Says:

I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like small rocks and hard to pass. I sometimes go several times a day but only small amounts at a time. I take 290mcgs every morning at least 30 minutes before I eat. It's usually over an hour before I eat anything. I do drink coffee or Diet Dr Pepper. Can you think of a reason why I'm having problems?

4 Replies

Earliest Newest Votes
Verwon Says:

Hello, Kaye! How are you?

Your body might just have become tolerant to the medication, this happens to everyone after having taken something for awhile, for some people one medication may last for years, but for others they can become tolerant much sooner.

Linzess has also not been successful for everyone that's tried it, quite a few people reported that it didn't work at all, or it worked for a short period of time, then stopped.

Has anything else changed recently, such as your diet or any other medications?

Typical side effects may include nausea, dizziness, gas, bloating and stomach pain.

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Leo Says:

Does an empty stomach mean liquids or can you have coffee before you take your Linzess?

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Richard Says:

Taking higher dose of Linzess for short of one week, have had neurogenic bowel for 20 years caused by spinal nerve compression at L4-5. Perform digital stimulation but nothing works except mineral oil / milk of magnesia or become impacted.
Recently put on higher dose of linzess and stool is slowly moving small amounts but while I've always had some blood present the blood has increased 5 fold. My GI Doctor seems like it's no big deal. Takes a while to get used to but I am not sure he has much experiece with CES / neurogenic bowel. Nothing new for me.
1. I've had it with the blood as it dissolves lubricant and makes it too slippery to pull out stool.
2. Can I use mile of magnesia with linzess.
Don't want bag as main exercise is in pool.

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Free at last Says:

Magnesium oxide 400 mg. 2-3 times per day cured my IBS-C. No more constitution. My life is 100% improved.

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