Linzess Not Working As Well

Updated

I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like small rocks and hard to pass. I sometimes go several times a day but only small amounts at a time. I take 290mcgs every morning at least 30 minutes before I eat. It's usually over an hour before I eat anything. I do drink coffee or Diet Dr Pepper. Can you think of a reason why I'm having problems?

4 Replies

Earliest Newest Votes
1

Hello, Kaye! How are you?

Your body might just have become tolerant to the medication, this happens to everyone after having taken something for awhile, for some people one medication may last for years, but for others they can become tolerant much sooner.

Linzess has also not been successful for everyone that's tried it, quite a few people reported that it didn't work at all, or it worked for a short period of time, then stopped.

Has anything else changed recently, such as your diet or any other medications?

Typical side effects may include nausea, dizziness, gas, bloating and stomach pain.

Was this helpful? 2
2

Does an empty stomach mean liquids or can you have coffee before you take your Linzess?

Was this helpful? 0
3

Taking higher dose of Linzess for short of one week, have had neurogenic bowel for 20 years caused by spinal nerve compression at L4-5. Perform digital stimulation but nothing works except mineral oil / milk of magnesia or become impacted.
Recently put on higher dose of linzess and stool is slowly moving small amounts but while I've always had some blood present the blood has increased 5 fold. My GI Doctor seems like it's no big deal. Takes a while to get used to but I am not sure he has much experiece with CES / neurogenic bowel. Nothing new for me.
1. I've had it with the blood as it dissolves lubricant and makes it too slippery to pull out stool.
2. Can I use mile of magnesia with linzess.
Don't want bag as main exercise is in pool.

Was this helpful? 0
4

Magnesium oxide 400 mg. 2-3 times per day cured my IBS-C. No more constitution. My life is 100% improved.

Was this helpful? 0

More Discussions:

Linzess not working

I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be...

8 REPLIES
Linzess not working for me

I was on Amitiza 24 mcg twice a day and Miralax was switched to Linzess 3 weeks ago. I am having so many issues, feeling...

3 REPLIES
Linzess not working completely

I've been taking Linzess about every other day for 2 months. Does anyone else experience some runny spurts than noth...

2 REPLIES
Linzess is not working!!!!

I started taking the low dose now I take too of them a day...only had one bowel movement when I started ...don't kno...

3 REPLIES
On Linzess for a week, NOT "Working" - HELP!

Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat...

59 REPLIES
I take linzess and it not working

I was told by my gastro doctor to take linzess 30 minutes before I eat anything on a empty stomach. but it not working. ...

6 REPLIES
Opana not working as well as OxyContin

I just had to switch from 2 x 80mg OxyContin ERs a day, to 2 x 40mg Opana ERs with 3 x 15mg oxycodone for breakthrough p...

2 REPLIES
adderall ir is not working as well as adderall xr

I recently switched from adderall xr 30mg to adderall ir 20mg because of the price of the medication. Now im in space an...

58 REPLIES
Phentermine 30 mg not working as well

The Phentermine 30 mg is not working as well as it use to. Will it hurt for me to take 1 1/2 pills at a time in the morn...

1 REPLY
Vyvanse and Armour Thyroid not working as well

I am 28 and had taken 30-60mg of vyvanse for 2 weeks and it was working very well. I recently started taking 30mg armour...