Janumet Xr (Thread 229049)

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Mary Says:


what is the differance between Janumet xr 50mg/100 mgand Glipizide 5 mg and can the be used together



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Verwon Says:

Janumet XR contains the active ingredients Metformin and Sitagliptin in a time released formulation to help better lower and control blood sugar in diabetic people.

https:/­/­www.medschat.com/­wiki/­Janumet/­

The Glipizide is a different oral antidiabetic medication.

https:/­/­www.medschat.com/­wiki/­Glipizide/­

Has your doctor instructed you to use both medications?

They can be taken together, but only if someone is experiencing high sugar levels that are hard to control, because it increase the risk of hypoglycemia.

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David Says:

The active ingredients of Janumet XR are Sitagliptin + Metaformin. Both of these medications are used in the management of type 2 diabetes. Glipizide is generally used along with diet and exercise, and (sometimes) with other medications, to treat type 2 diabetes. The primary differences between all three of these drugs lie within the chemical makeup of each drug, as well as the addition of certain "inactive" ingredients that may or may not be present in each tablet.

Both of these factors play a detrimental role as to how each drug is metabolized and used by your body. Because everyone is different, your body may agree with one medication over the other, due to how you feel or based on whatever side effects present themselves.

In regards to taking them together, the only interaction is of that between Glipizide and Sitagliptin. This interaction states the following:

"ADJUST DOSE: Coadministration of a dipeptidyl peptidase-4 inhibitor with an insulin secretagogue (e.g., sulfonylurea, meglitinide) or insulin may potentiate the risk of hypoglycemia.

MANAGEMENT: A lower dosage of the insulin secretagogue or insulin may be required when used in combination with a dipeptidyl peptidase-4 inhibitor."

Personally, I wouldn't want to risk the interaction of taking them together, coupled with the side effects of each drug. You may want to just make some dietary changes to help make 1 drug more effective.

NOTE: studies have proved that a low fat - high carb - raw vegan diet can reverse and cure diabetes type 2, and even control diabetes type 1 without the use of medication. Just thought I'd throw that in there! :)

I hope this helps!

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