Interactions Lisinop/hctz 20-12.5 Tab & Hydroc10/apap325 & Bupropion Hydrochloride Sr 150mg

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Kathy Says:


Is there any bad drug interactions when taking Lisinopril and Hydrochlorothiazide 20/12.5mg for high blood presure-once a day with Norco 10/325 twice a day for pain with Bupropion Hydrochloride Extended-release tab (SR) 150 mg twice a day for depression?
I have already been experiencing constipation but is there any others anyone can share or tell me about?



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David Says:

Based on my research, a few of your medications do list potentially unsafe drug interactions. Quoted below are the precautions you should be aware of:

Applies to: Bupropion + Norco (acetaminophen/hydrocodone)

"Talk to your doctor before using Bupropion together with Hydrocodone. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol during treatment."

Applies to: Bupropion + Hydrochlorothiazide/Lisinopril

"Hydrochlorothiazide/Lisinopril and Bupropion may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position."

That said, you may still want to go ahead and discuss these concerns with your doctor just to make sure you remain on the safe side of a potentially serious interaction.

I hope this info helps to answer your question!

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