How Many Minutes Hours Is Active Ingredient Hydroquinone Effective

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Tink Says:

After hydroquinone is applied to face, how long is that ingredient active on the skin? Minutes/hours?c

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David Says:

Even though human absorption of Hydroquinone upon topical application is less efficient than with oral administration, Hydroquinone elimination occurs rapidly, primarily via urine.

It's half life can vary based on my research, but one trial concludes that:
A review found that in "F344 rats", the blood elimination half-life of hydroquinone administered i.v. was 18.7 min and that with oral administration was 14.8 min. With i.p. administration to "B6C3F1 mice", the hydroquinone half-life was 9 min.

As that study was done with rats, I did opt to look for other details, which indicated that the half life was 12 hours or roughly half a day, with it's peak plasma concentration levels at the 4 hour mark.

Trying to piece this information together is a challenge indeed since there doesn't seem to be enough definitive claims on the drug as of yet. However I would imagine that after the 4 hour mark and certainly by the 12 hour mark, it wouldn't be nearly as active on your skin.

Hopefully someone else can step in to verify these details, but going off of the half-life is probably the most accurate way of depicting a drug's activity.

I hope this helps!

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