Having Problems With Delzicol

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Don Says:

I have been taking 400 MG No problems, been feeling fine. When I renewed these pills, they are somewhat different. Instead of one red pill, it comes in a clear capsule 4 pieces of the pill in 1 capsule. Shortly after taking these pills I have been having problems. Stomach pains, nausea, cramps. Been going on for a few weeks now. Any suggestions??

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Mark Says:
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I also have not agreed with the new capsules. I feel like they are better than nothing at all but not doing their job in comparison to the last formulation. I wonder if we can open them up and take the small capsules...

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David Says:


Sorry to hear about your experience with this new refill. I'm assuming it's probably from a different manufacturer with different binders and fillers that could be to blame... However, it's important to note that the US National Institute of Health lists, "severe cramping, stomach pain & nausea" as side effects of Delzicol (Mesalamine) that should be reported to your doctor immediately.

Source: ncbi.nlm.nih.gov/pubmedhealth/PMHT0011105

Given this information, these symptoms may or may not go away on their own; until you stop taking what's causing them to begin with. Maybe for future scripts, your doctor can specify a particular manufacturer's version of the pill that you received before?


I've heard of people attempting to do what you suggested with regards to others types of medication (taking the beads out to get a smaller dose)...but I'm not sure if the capsule itself lends its own unique properties that affect absorption? I'd consider asking a pharmacist or the drug manufacturer themselves just to be on the safe side. It's an interesting question that I've never seen a straight answer to...

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