Generic Modafinil, Provigil (brand) Or Nuvigil Experiences

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MostlySaneCatGentleman Says:

Hey all,

1. Anyone tried varying generics of Modafinil? Which ones, and did they work? Anyone tried brand Provigil (super pricey!) as well and can compare the two?

2. Anyone try Modafinil or Provigil and also tried the considerably cheaper brand Nuvigil (or even generic Nuvigil; please specify which generic). Did they affect you differently? How so, especially in terms of mood, motivation, energy, wakefulness, and task initiation (the latter for ADHD people). How long did it last, and how much longer than Modafinil/Provigil?

Please include what doses were optimal!

The full story:

I have severe ADHD and severe excessive daytime sleepiness since childhood and adolescence, respectively. Perfect physical health otherwise. ADHD meds help many of my ADHD symptoms, but do nothing for my fatigue and lack of energy. On the contrary, they (paradoxically) relax my hyperactive and impulsive brain so much that they may even contribute to my fatigue!

My psychiatrist suggested trying Modafinil (Provigil) or Armodafinil (Nuvigil) for the EDS and since it is also used off-label for ADHD, she thought it might also help the few symptoms my ADHD meds aren't helping: procrastination and low motivation.

I thought this was very promising, as a few years ago I was on a road trip and getting very tired and a friend gave me a pill to wake me up that she told me was "an energy supplement, but not caffeine" (caffeine makes me jittery, drops my blood sugar too low and does not wake me up much). Turns out it was adrafinil, the no-prescription-needed cousin to Moda, sold as a dietary supplement. It is weaker than Moda and, as I learned later, is tougher on the liver and takes longer to kick in/lasts long enough to impede sleep, so it's definitely not recommended! But I found it did keep me awake, and also made me feel more motivated to accomplish tasks.

The issue is this: I have always had issues with various generics and never with brand names of psychotropic drugs. Since my state does electronic scripts only, I cannot ask around what pharmacies have what generics, and truth be told I'm tired of generic roulette. So I have my Dr mark "brand only".

The problem here is that the cost of brand Provigil is ASTRONOMICAL. The cost of brand name Nuvigil is a lot less, but it only has the R-antinomer of modafinil (and therefore the generic is called armodafinil) while Provigil has both R and S entianomers. Since I responded to Adrafinil, which breaks down to Modafinil in the liver, I worry that I might need both R and S for therapeutic efficacy re: both wakefulness and motivation, so Nuvigil might not work as well. Another concern is I believe Nuvigil lasts longer (how much so if true?) and I do like a regular sleep schedule.

My other option is just taking the generic Modafinil offered by Aurobindo, a generic I have had problems with in terms of generic Adderall IR. The only other common generic around here is Teva (whose generic Adderall IR, generic dextroamphetamine IR, AND generic Zolpidem didn't work for me either!) I have heard one person online, though, say that generic Aurobindo Modafinil was fine, but I'd like more than a sample size of one!

Please let me know what doses worked/didn't work/caused side effects. My doctor told me that sometimes less is more for this drug!

Thank you so much! My appointment is soon, and once I have enough information to go on, I can make a choice and hopefully it will be the right one and won't spend half my daytime hours napping!

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Bobby Says:
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I know I personally went through all the amphetamine meds and Adderall ir prob worked the best but that was years ago when the generic s were better quality. I tried nuvigil hoping maybe it would have less side effects and be better. It felt ok for like an hour than I got really depressed and the rest of the day I felt awful. So never again as far as those. I since went back on Adderall ir and the only one that I can tolerate is the teva but it's not the same as it was years ago even. I guess you could try more of those generic modafinil products if you like the effects better but I found them to have less positive effects than Adderall or dextro and more negative personally. Good luck

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Hop63 Says:

I take modafinil generic. I liked Provigil much better. I have narcolepsy. I have been taking it since 2008. It does work but there is a difference between the Provigil and generic modafinil. I think there are differences among the different generic brands I have received. My insurance won’t pay for the brand name. Must take whatever generic is given to me. I have not had any side effects.

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w john Says:

Re: Hop63 (# 2)

I have been on Modafanil for over 3 years. We discussed what my Doctor described as the "adrenalin drugs" i.e. Ritalin, and other amphetamine based drugs. My Doctor (and the research I read) said, that while the amphetamine based drugs is tantamount to pharmaceutical speed, Modafanil and/or Provigil is not addictive. That is a big plus to me. I do NOT want to become addicted to pharmaceutical speed. For that one reason alone Modafanil is my choice. I have stopped taking this medication for up to three weeks at a time with no withdrawal whatsoever. Anyone that takes any pharmaceutical speed for any length of time wil lbecome AT LEAST dependent on the medication. Modafanil and/or Provigil can be stopped immediately without any withdrawals. As far as brands go I have only tried two brands--Mylan and Cephalon. I prefer the Cephalon brand. if you like the "speed" high and rush you will not like Modafanil because, while Modafanil will keep you awake, it will not give you any "high" or "rush". I PERSONALLY find it better to take 200 mg--100 mg in the morning and 100 mg in the early afternoon. Taken too late in the day for ME will keep me up too long. This is my PERSONAL experience of over 3 years. I hope it helps. Btw, before this Modafanil was prescribed I had to go to TWO overnight sleep studies two weeks apart AND under go CPAP therapy which I am still on.

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