Glyx-13 Discussion (Page 2)

There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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@Catpower- I will look for the DBT, I never heard of it either.
AZD6765 - I did a lot od research, especially in other countries. It is almost the same as Ketamine, and lasts a vert short time. Shorter than Ketamine.
@Daisy too, what will happen when the studies are over? Will you still be able to get the medication? Or when it's over, it is over?

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All - below is hopefully a link to an article about J&J's phase 1 drug, esketamine! There is a (ph 1) trial going on in Belgium right now showing good response. Sounds like the whole NMDA receptor theory in depression/anxiety is Pharma's big new thing. Note, esketamine is an intranasal spray, not an IV drug. ****YAY****

seekingalpha.com/article/1542392-from-party-drug-to-antidepressant-johnson-johnson-vs-rivals?source=email_rt_article_readmore

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ALL, ACCORDING TO A 2012 SCHOLARLY ARTICLE, IT IS POSSIBLE THAT THERE ARE OTHER NMDA RECEPTOR MODULATORS, IN USE, AND FDA APPROVED, SAFE, BEING USED FOR OTHER HEALTH ISSUES RELATED TO THE SAME AREA OF THE BRAIN AND THE GLUTAMATE SYSTEM.
IT IS POSSIBLE THAT ONE OF THEM COULD ACCELERATE AND OR ENHANCE ANTIDEPRESSANT EFFECTS OF CURRENTLY AVAILABLE TRADITIONAL ANTIDEPRESSANT DRUGS.
THIS IS THE BEST NEWS YET, AS IT IS ALL SAfe and available now!
i.e. MEMANTINE AND AMANTADINE ARE BOTH NMDA RECEPTOR AGONISTS, WITH FLUOXETINE.
APPARENTLY AN NMDAR IS NOT THE WHOLE STORY, AS SHOWN BY THE TEMPORARY IMPROVEMENT WITH ALL OF THESE NOVEL MNDA RECEPTOR AGONISTS. THAT THE NEURO TRANSMITTERS AFFECTED BY ANTIDEPRESSANTS ARE STILL AN IMPORTANT PART OF THE PICTURE. NEITHER ALONE WORKS.
AS OF NOW THERE IS NO RX FOR TRD.
IF ANYONE WANTS TO READ ORIGINAL ARTICLE FROM PUBMED, LET ME KNOW AND I WILL SEND THE LINK. I AM GOING TO START ASKING MY DOCTORS FOR THESE MEDICATIONS, SINCE THEY ARE SAFE AND TRADITIONAL.
****HAVE ANY OF YOU LONG TIMERS NOTICED COGNITIVE IMPAIRMENT?
IT APPEARS THAT UNTREATED TRD CAUSES IT AS WELL AS EARLY DEMENTIA. THIS IS SCARRY, AS I HAVE NOTICED EVER INCREASING.
EARLIER HELP MAY BE COMING!

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Blueheelercd, yes, I've noticed a slight improvement in memory. What is a TRD, btw?

Had another treatment yesterday. Feeling pretty tired today, but I know it will wear off.

Catpower, I tried the ketamine nasal spray, and it made me feel really strange, so I discontinued. I would sure like to give the esketamine spray a try if/when it's approved, though.

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BlueheelerCD, can you post the link to the 2012 pubmed article? I don't think MedsChat has a problem with posts tho seems like sometimes they like to review stuff before posting. Thanks and thanks for all the info.

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ALL - TRD IS TREATMENT RESISTANT DEPRESSION
MDD - IS MAJOR DEPRESSION DISORDER
NASAL SPRAY OF ANYTHING DOES NOT HAVE ENOUGH BIO-AVAILABILITY AND DOES NOT CROSS THE BRAIN BARRIER. THIS HAS ALREADY BEEN PROVEN IN CLINICAL TRIALS AND SCHOLARLY ARTICLES.
YOU ARE JUST GETTING RIPPED OFF.
KETAMINE AND GLYX-13 ARE NMDA RECEPTOR MODULATORS.
THAT IS WHY IT IS EXCITING THAT THERE ARE AT LEAST TWO OTHERS THAT ARE ALREADY IN USE, FDA APPROVED, AVAILABLE NOW. MINIMAL SIDE EFFECTS. PILLS. BIOAVAILABLE! THIS IS WHAT IS SO IMPORTANT.
IT WILL BE AGES BEFORE GLYX-13 IS AVAILABLE.
THAT IS WHY WE HAVE TO ASK OUR DOCTORS FOR WHAT CAN POSSIBLY WORK NOW PLUS AN OLD RELIABLE ANTIDEPRESSANT WITH THE FEWEST SIDE EFFECTS.
DAISY-THAT IS WHAT AN MDNA RECEPTOR MODULATOR DOES, IT WORKS ON ALL COGNITIVE PROCESSES. GLAD TO HEAR IT HELPED!
BEFORE TRIAL WERE YOU BEGINNING TO OR HAD COGNITIVE AND MEMORY PROBLEMS????
NEW INFORMATION HAS COME OUT THAT BECAUSE KETAMINE IS SO DANGEROUS AND CONTROLLED IT WILL NEVER BE AVAILABLE. THE BEAUTY IS THAT IT OPENED UP THIS WHOLE NEW ARE OF BRAIN RESEARCH CALLED THE GLUTAMATE SYSTEM AND ITS DISFUNCTION BEING A MAJOR PLAYER IN DEPRESSION.

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Blueheelercd, are the caps on for a reason? Feels like you're shouting...

There is actually a doctor administering ketamine intravenously for depression in my city, I've been told. His name is Dr. David Faifel, and he works at UCSD Medical Center.

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All-sorry I just can just type faster. Time will tell. Ketamine is Not sanctioned by the National Institute of Mental Health. Nor is anyone trying to get approval from the FDA for an Intravenous Anesthetic for Depression. Nor are there anymore trials. Dangerous side effects,
Daisy, are you in LA? me too. Who is your regular Psychiatrist?
Where are you doing the GLYX-13 trial?
I got rejected for Breast Cancer. I cannot get into any trials.....
I called USC way back. They only use it for pain for a specific type of disease for pain treatment. That is what they told me on the phone. The MD that was doing it at UCLA, where I go, stopped.....

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As I stated before, I'm in a trial of AZD6765. I don't live in LA, but you can check to see which trials are being conducted there by going to clinicaltrials.gov

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Daisy- what are the specifics of the AZD6765 trial? You mentioned that there was a high-dose and a low-dose group. Is there a placebo group? Typically these trials will always have a placebo group.

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Please add me to the GLYX-13 discussion thread...I am in the ketamine thread.

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Temp798,

Yes, there is a placebo. I know that I'm not in that group though, because of the way I'm feeling.

I can post which dose I'm on if/when Astra Zeneca unblinds the trial, if anyone wants me to.

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I went to the trial place for GLYX-13 and they were about to interview me to be in the trial. But then, the bombshell...2 week washout period for the Wellbutrin, I can't take the chance of becoming so depressed I will need to be hospitalized. So I decided not to participate. ): The woman there said she had seen some incredible results for people, I know this, I have experienced 'the miracle'. I just can't go back to *the hole*, barely hanging on now. But very interested to hear of others experiences. Best of luck to everyone!

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Paula,

AZD6765 is being studied only as an adjunct medication, so you actually have to be on an A/D to qualify for a clinical trial.

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Dear All - There's been some discussion on this thread about FDA-APPROVED drugs that are NMDA receptor antagonists (i.e. same class as ketamine, and related to experimental drugs like GLYX-13). One of these approved drugs is Namenda, aka memantine, an Alzheimer's drug that is also being studied off-label for use in migraines, depression and anxiety (among other things, but those are the 3 from which I suffer the most). Anyway my neuro gave me a sample pack yesterday!! so I have started down the Namenda path. The pack is a month's worth so I can't say I've noticed anything yet, in fact I've had 2 migraines since starting it yesterday, but that could be the horrible hot and humid weather we're having in the Chicago area right now. At least I'm hoping it's the weather, because I'll be very disappointed if Namenda turns out to be a freaking migraine trigger for me. Anyway I'll keep posting about this drug if folks are interested. It is a legal drug, available by prescription, and as has been mentioned previously I think works on the glutamatergic system, instead of serotonin like most current ADs. All SSRIs and SNRIs are migraine triggers for me, so this new approach could be a breakthrough for some of us, maybe a lot of us. Best wishes to all :)

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Catpower,

A doctor prescribed Namenda for my depression last year for the reasons you stated, but I was afraid to take it for fear of the side effects I'd read about it.

Regarding your migraines, have you tried the SNRI Remeron (mirtazapine)? I used to get migraines too, and they pretty much disappeared after I started taking Remeron. It's the only a/d I can tolerate, and I still take it. I realize that everyone's different, though.

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Yes, I tried remeron. It didn't help the migraines but made it impossible for me to stop eating :) I haven't met a SSRI or SNRI yet that I can tolerate. Thanks for the thought tho!

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Daisy, after only 3 days on Namenda, it appears to be a migraine TRIGGER for me all. Either that or it's the weather. I'm going to stop taking it and maybe give it another try when the weather clears up, if I can stand the thought of it.

I was curious what side effects you had when you tried it? I had 3 days of unrelenting migraines almost from the minute I took the first pill. Very disappointing to say the least, because I was hoping it would help my anxiety. If anyone else has experience with this, I would appreciate hearing (tho maybe I should switch to the Namenda page - if there is one - arrrrggghhhh)

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Hey Catpower,

I filled the Rx for Namenda but didn't take it. I forget what I read about the side effects that decided me against it. I wouldn't be surprised if that's what's causing your migraines.

I'm still very pleasantly surprised at how few side effects I've experienced from the AZD6765 infusions compared to all the pills I've tried. I'm having my next-to-last infusion on Wednesday.

Sorry about the weather you're experiencing. I'm originally from NYC, so I know from humidity. Live in San Diego now, which is much more bearable...I've met people who do suffer headaches when the barometer moves in one direction or the other.

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Hi Daisy

If it's not too much to ask, could you tell us a bit more about how the treatment works for you in terms of attention, memory, cognition, energy and emotional depth? I too have quit SSRIs because of terrible side effects and I am awaiting this new drug class. SSRIs made me have dampened feelings and killed my libido. Have you noticed anything similar with AZD6765??

I wish you all the best with the trial.
thanks

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