Desvenlafaxine (pristiq) And Simvastatin

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Karen Says:

For at least a year or more I've been taking pristiq (generic) and simvastatin at the same time. I felt that the pristiq was no longer working because I was so very tired all of the time. It dawned on me that maybe there was an interaction between taking simvastatin and pristiq at the same time. I took them separately at least 3 hours apart and today have more energy and as the day wore on kept felling better. I know there isn't supposed to be an interaction if you take them together, but I can't help but think there is. Has anyone else taken them at the same time and then stopped taking them together and had better results with not feeling so tired all of the time and listless?

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David Says:

Hi Karen,

I just wanted to add another perspective or insight into your understanding that there's no interaction taking place... Could the tiredness simply be a common side effect of taking either medication and not relating to interactions at all - in so far as both meds weighing too heavily together on your system at once, at that specific dose, whereas a lesser dose or taking them a few hours apart allows for your body to more easily process and take in the chemical response, so to speak? I hope that makes sense. It just occurred to me that if there's no drug interaction then maybe this could be an underlying cause...

On a side note, "unusual tiredness" is specifically listed as a general side effect of Simvastatin.


"Tiredness & sleepiness" are also listed as general side effects of Desvenlafaxine (Pristiq).


Hope this helps!

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Kathie Says:

Re: David (# 1)

I take the genericPristique and am exhausted all of the time. I sleep 10 hours at night and have to have about a 2 hour nap during the day.

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Shiraz Says:

Re: David (# 1)

Almost all antidepressants make you tired and also kill your emotions.I am on effexor and mirtaz. Feel tired and numb.

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Karen Says:

Re: David (# 1)

Thanks so much David for your replies.

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