Why Is Contrave Not Working Anymore?

Just Me In CC Says:

I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it has not been working after that 10 months. I don’t have any side effects, but have a ridiculous appetite now. Almost to the point of wanting to binge eat. Anybody else been on it a while and have it stop working? I’ve gained almost 10 pounds back in the last few months. I’m not sure whether to ask my doctor about stopping it, but I’m afraid my appetite will be even worse. Anybody?

57 Replies (3 Pages)

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Sammy123 Says:

I had the same problem. I was starving hungry and wanted to eat and eat. Weirdest thing was that I felt constantly hungry even after a week?

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Verwon Says:
Top Answer

Why is Contrave not working?

According to the official manufacturer’s website, there are a number of possible reasons why you’re not losing weight: MedlinePlus also goes on to note that patients should not take Contrave with a high-fat meal; as I presume that doing so may impair the drug’s absorption and overall efficacy.

On a side note, you are not the only people who have experienced such issues. Most people who have tried Contrave have reported eventually hitting a plateau period, where it seems to stop working for a while, but they have also said that it does start working again after about a month or so, though that can vary from person to person.

The FDA lists its typical side effects as possibly including nausea, dizziness, dry mouth, headache, anorexia, and mood changes.

Can anyone that's taken this chime in with their experience?

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Vixenvella Says:

Re: Verwon (# 2) Expand Referenced Message

I took contrave for about 7 months lost about 18 lb then it just started not working and my blood pressure was getting increasingly higher even to the point where I would have to go on medication. Went off the contrave for 3 months and took Adipex basically just maintain the weight loss of 15 lb. I went off Adipex and started back on the contrave and I'm on week 4 just started the four pills a day and it doesn't seem to be doing anything. Any advice?

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Susie Says:

I am on week 3 of taking Contrave. I have seen no results. In fact it has increased my appetite and I am gaining weight. Depression is setting in now. I am so bummed out and don’t know what to do. I have changed up my diet and workout 3 times a week. My dr also has me on phentermine. When I was taking phentermine alone I lost over 30 pounds (of the baby weight I gained and couldn’t lose). I hit a plateau and my dr suggested this. I am trying to stay positive but it has been hard watching my hard work, work against me! I called my dr today and left a voicemail. Anyone else have this happen? All my hard work of losing the 30lbs just to start gaining it back has me super upset!

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Mretz Says:

Re: Verwon (# 2) Expand Referenced Message

I am just where you folks were. I’ve been taking it since October and was doing great. Took my cravings away, made me not want any alcohol and no side effects. All of a sudden the cravings are back and I’ve gained 2/3 of my weight back in a month. Really depressed about it.

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slow go Says:

After 2 full months on contrave I've only had 2 pounds of weight loss. I have been wise about my eating. Has anyone else had this problem?

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Sheryl Says:

I have the same problem I have lost only 24# in 5 months and it stopped working l’m running out of options

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Damiana Says:

Yes! I’ve been taking it for two years. I lost 150 lbs and was within 10 lbs of my goal weight. Then a number of things happened in my life, and I have gained 30 of it back. I exercise religiously and try to eat well, but I know I’m eating more. And, I haven’t been able to say no to the sweets. I’m pretty stable at this higher weight, but it isn’t where I want to be.

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Damiana Says:

I had that problem with Meridia. I didn’t eat all for two weeks. Then I spent two weeks literally eating everything edible in sight. I haven’t had that problem with Contrave. The change has been much slower, but the appetite definitely has come back.Sammy123 (# 1) --

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Tom Says:

I've been taking contrave for 3 months, lost 10 pounds. Seems contrave does not curtail my appetite any more. Should I stop taking it for a while then restart?

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Donna Says:

Re: Verwon (# 2) Expand Referenced Message

much hair loss along the front hair-line. Stopped taking after noticing this. Appetite has returned. Gaining weight again. Using Nioxin shampoo and conditioner and biotin. Seeing hair returning. Afraid to take Contrave now. Help....

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Judi Says:

For how long does Contrave remain effective? I have been on it for 6 months and it seems to be much less effective. Is there a time period for taking Contrave?

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Patsy Says:

I’ve been taking Contrave for six months and have lost all the weight Inwsntrd to bIt was wonderful, my appetite went away I had to remember to eat. I went off Contrave for two months. My appetite returned but not to bad. But I still needed to lose more weight. I was put back on Contrave and it doesn’t have the same effect as it did the first time. Has anyone had this problem? Has anyone ever had their contrave increased? Has anyone had the same problem? Please let me know.

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Christine Says:

Re: Damiana (# 8) Expand Referenced Message

I had a similar experience. I lost 76 pounds in the first year and an additional 10 the second year. I'm now on the 3rd year and have gained back 11 pounds. I have cravings worse than I ever had and have no idea how to stop them. It's definitely discouraging, especially after how amazing I felt before.

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Patsy Says:

I stopped taking it after achieving my ideal weight. A few months passed and I was eating everything. I went back on Contrave to no avail. It wasn’t working.
What happens ?

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Tawktame Says:

Re: Patsy (# 15) Expand Referenced Message

I've been on Contrave since Dec 4, 2018. I lost the majority of my weight the first 4 to 6 weeks (about 20 pounds). The past three weeks I've had little, if any, weight loss and my appetite and cravings are coming back.

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Frustrated Says:

I lost 60 lbs in a year and a half. Didn't want sweets or alcohol, felt amazing. Then one day the cravings came back and I cannot stop eating. It's worse than before and I'm gaining the weight back, 10 lbs in last 4 weeks. Looks like we're not alone but sure wish I was seeing a solution on here.

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Patricis Says:

Why are you asking us to talk about how Contrave is now not working ??? Why isn’t the manufacturer telling us why ? I can complain all day and post it so others in my shoes can add to it. We want answers.

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Netty Says:

Same. I started May 2018 and I stopped losing November. Down 30 pounds and yes I’m starving

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Dee Says:

Re: slow go (# 6) Expand Referenced Message

I started Contrave on 12/4/18 and lost about 23 pounds in an 8 week period. At around the 8-week mark (January 21, 2019) was when my weight loss completely stopped. I have been on the script for 6 months and have had NO weight loss since January. Doc said I have plateaued and he said I could now stop taking the medication because it will no longer work. I asked if I could just stop taking this medication abruptly and he said YES? Hmm...I don't know about that. You just don't stop taking an anti-depressant with no side effects. I'm finishing my last script and calling it quits. The meds are doing absolutely nothing for me. I have my full appetite back and all my night-time cravings are back, too. Contrave did work and I lost the weight I wanted to lose, but it does stop working. Mind you, this was following a 1200 calorie a day diet. The 1200 calories daily was doable the first 8 weeks and after that my appetite and cravings all came back with a vengeance. There's very little positive feedback with Contrave. Results are minimal. I don't think this medication is for anyone who is "obese" and looking to lose an extraordinary amount of weight. You may be able to reach that goal by implementing a calorie deficit while taking the medication. If you're looking to lose about 15 to 25 pounds this medication may be helpful in reaching that goal. I've read where people have been on the meds a year and only lost 18 to 20 pounds?? Not sure if that sort of weight loss is worth the cost of the script and the amount of pills you have to take daily (this medication is an antidepressant (Wellbutrin) and also contains Naltrexone (used to blocks the effects of opioids)). I am a 51 year old woman going through menopause. I am currently on Effexor for hot flashes (works GREAT for hot flashes - horrible to come off that medication though). Anyhow, once I started taking Contrave the Effexor stopped working immediately and my hot flashes are all but unbearable. That's my story. I hope it was helpful.

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Most Recent Replies:

BM Says:

Hi, I’ve been takeing Contrave for about 9 weeks now first 5weeks I lost 11 pounds but since then I’ve kinda hit a platue but still seems to be loosing some inches I don’t exercise scatter walk so his this normal.

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Monica Says:

Re: Damiana (# 8) Expand Referenced Message

My sweet tooth has been crazy the last year, too!

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Di Ane Says:

Re: Red (# 35) Expand Referenced Message

Which one worked for you?

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Di Ane Says:

Re: Polly (# 50) Expand Referenced Message

Polly, how have things been going? I have had a similar response but I don't want to go off of it just yet. Down 7 pounds in 3 months of being at full dosage. No side effects just not working too well.

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Stefani Says:

Re: Red (# 35) Expand Referenced Message

If you don’t mind me asking, what did you have better luck with?

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Parker Says:

same here. Binge binge binge on Ben & Jerries Ice Cream

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Stefani Says:

Re: Patsy (# 13) Expand Referenced Message

Did you get any answers? I’m having the exact same issue.

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Polly Says:

I started contrave and over 2.5 months lost 15 pounds. I didn’t think about food and was not hungry. 5 days ago I felt the urge to binge eat and it’s still with me. I’m taking the max dose. I hope this goes away because it was great not to obsess over food finally.

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NanaBird Says:

Re: Rachel (# 48) Expand Referenced Message

Hi Rachel...just have a question for you. Does the contrave give you excessive energy and motivate you to get things done? I've lost 30 lbs. since March and have 70 left to go. It isn't working as far as the weight loss right now but I'm not eating a very healthy diet. It did really help improve my sleep for awhile but doesn't do that anymore.

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Rachel Says:

It's stopped working for me too. I've been on it for 5yrs. I did lose 65 pounds at the beginning, but I could tell it wasn't working like before. I asked my doctor about it, and he said I was probably immune to it. They're are times that I feel it's working. Since Covid I've gained 15 pounds, and having a hard time losing it. I do feel the cravings, and I catch myself wanting to eat. I'm afraid to get off them, and risk gaining all my weight back.

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