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I've been doing very well with Complera since January. I have been wondering if I can take 5HTP with it. I am a 50 year old female in fairly good physical health but I'm really depressed and low on energy. I use to take 5HTP a few years ago and had great results with it but need to see if it can work again. Don't want to mess up the Complera so any help would be appreciated! ## Hello, Bear 50! How are you? I didn't find any interactions listed between them in the MedScape database, but it's always best to double check such information to be safe, but if your doctor approves, there shouldn't be any problem with your taking it. According to the FDA, Complera is used to treat HIV and it may cause side effects, such as nausea, headache and insomnia. Is there anything...6 REPLIES Updated