Citalopram And Phentermine

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Andrea Says:


I've been taking Citalopram for a week now, so far so good except for feeling a little tired but hoping it will go away. I want to continue with my weight loss program taking a half of 37ml of phentermine so I can get the energy I need in the morning at the gym, don't want to feel too anxious. Has anyone experienced any interactions or any weird side effects with this combination? Thank you so much.



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David Says:

Hi Andrea,

Based on my research, there is an interaction listed between these two medications; which states the following:

"GENERALLY AVOID: Several case reports suggest that serotonin reuptake inhibitors may potentiate the pharmacologic response to sympathomimetic agents. The exact mechanism of interaction is unclear. In one case report, a patient experienced jitteriness, racing thoughts, stomach cramps, dry eyes, palpitations, tremors, and restlessness following a single dose of phentermine ingested approximately a week after she had discontinued fluoxetine. Because of the long half-life of fluoxetine and its metabolite, an interaction with fluoxetine is possible. Similar toxic reactions have been reported when fluoxetine was used concomitantly with amphetamine or phenylpropanolamine. Additionally, some sympathomimetic agents such as amphetamines may possess serotonergic activity and should generally not be administered with serotonin reuptake inhibitors because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. The interaction was suspected in a patient treated with dexamphetamine who developed symptoms consistent with the serotonin syndrome approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine."

"MANAGEMENT: In general, amphetamines and other sympathomimetic appetite suppressants should not be combined with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Close monitoring for enhanced sympathomimetic effects and possible serotonin syndrome is recommended if these agents must be used together. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea."

I'd like to also add that weakness and excessive tiredness are both listed as side effects of Citalopram. If these side effects become too bothersome or severe, you may want to consider switching medications or opting for a more natural approach.

I hope this information helps!

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Andrea Says:

Thank you David!!

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jennifer Says:

Can I take citalopram10mg and phentermine 27.5mg together

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Bigmike1285 Says:
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My Dr. prescribed me 37.5 mg of phentermine and 20 mg of celexa (citalopram) because I'm so over weight and I have social anxiety with a bad stutter. Is it safe to take these together? Because I have read a lot of reviews saying it's not safe to do so.

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Cyn Says:
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Re: Bigmike1285 (# 4)

Yes it is safe to take together I have been taking this combination for 5 Years or more for my PTSD / depression and weight control

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