Brintellix (trintellix) Withdrawal

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Judi Says:


Started 10 mg Trintellix 3 weeks ago. Vomiting at least 2x a day and constant nausea, fatigue, muscle and back pain. Trying to wean off it - doctor said take it every second day for a week then go see her. What is the normal time frame for withdrawal? I am terrified of this drug. I am diabetic and it is making my sugars wildly fluctuate too.


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Judi Says:

Called Lundbeck (canadian office in Montreal) today to get advice on how to wean off/stop taking Trintellix. Shocked to be told "there is NO protocol for weaning/stopping this drug. You have to let your doctor decide how to proceed"! "Everyone has a different reaction". My doctor is away for a week so. My pharmacist and I are trying to figure something out, but I am absolutely stunned at Lundbeck's answer

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David Says:

Hi Judy,

Sorry to hear about your challenges with Trintellix. The answer that Lundbeck gave you sounds like the ugly / sad truth with many types of pharmaceutical medications... where it seems patients are the guinea pigs of this vast experiment society calls big pharma. I believe their clinical trials only go so far and that's why they don't know what to do... However with a doctor's help there are "safe" ways to taper off anything and they can help you do it in the most subtle and concise manner to mitigate possible risks or side effects upon doing so. In the meantime I would encourage you to stay positive and optimistic when it comes to finding a solution and peace of mind in the process. Will look forward to any future updates you might have. Warm regards~

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Kywoman Says:
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I want to wean off of trintellix. I started it in March. Dr worked me up from 5 mg to 20 mg. But the weight gain is horrible. I came off of effexor a couple of years ago and the withdrawals were horrible. Any experience with this?

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Greg Says:
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I started around march also. I am taking 20 mg and i am very nauseous. I am not sleeping very well also. I have decided to stop taking it, not sure how. I'm thinking i will go to 10 mg a day for a week, then the following week every other day. Then the following week i will stop. Too much nausea and very tired and still very depressed and anti social. I also think of dying too much. I have tbi from 2 years ago. I wish you the best of luck!

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Click Says:
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Good day everyone,

After taking Trintellix for over a year now, I decided to quit cold turkey. This medication made me feel nauseous, super depressed, caused weight gain, made me antisocial and I regularly had thoughts of suicide. Since quitting on June 29th, 2017: Days 1 through 5, I have had no bad side effects. The positive side effects for me are crystal clear thoughts, zero depression and no suicidal thoughts whatsoever. I feel like a new person, well actually, I feel like myself again. I can't believe that I let this medication screw my life up for so long. I decided to take control of my life on June 29th. Instead of taking medication, I am using physical activity to get back into shape. I am taking over my life again. I will no longer be visiting the pharmacy each month to pick up meds. I feel invigorated now. 5 days and counting, no longer in the routine of waking up and starting my day washing down pills.

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Kywoman Says:
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How did the weaning go? I had no withdrawals, and feel so much better. I still have the extra weight I gained on meds, but I've not gained any additional.
Best of luck!

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Gb Says:
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Well , a bit of a failure. I went to 10mg and stopped taking sleeping pill too.
I ran out of 10 mg after 5 days , after a few days without i went bAck to the 20mg.
I am going on bike ride in early morning and falling asleep around 8 or 9..
Oh well , no sleeping pills is great for me .i see neuro doc next week and will ask her for 10 mg . If i can stay on my bike i will just stop within a few weeks.
Thanks for asking.


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Helper Says:
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Nausea and vomiting are transient side effects that some people might experience for the first 2 weeks. You can stop the medication if you want.

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Jenn Says:
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I take mine at night because of the nausea. I am presently weaning off this med. Dr. Advised me for first week take every other day. Second week, every 2 days, etc.

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EarlAge76 Says:

I took 5-10 mg of Brintellix for 5 weeks. Didn't like the brain fog. Was told by my MD to stop the current dosage of 5 mg after 3 more days. Since then my brain fog has not cleared. Any idea how long approximately before I get relief? My brain has always been sensitive to this type of medication.

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wauden Says:

Click (# 5) -- I read your post about withdrawing from Trintellix and I'm hoping you will post about your experience and how you're doing now. I'm in the process of withdrawing from this drug as well and would benefit from your experience.



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Zee zee Says:
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Kywoman (# 3) --

Did you figure out how to taper off? I am in the same situation. Also how much weight did you gain? My doctor said it shouldn't cause weight gain it I have also gained a lot of weight and think it might be the Brintellix. It hasn't helped that much with my depression so I don't mind going off it. I hope you have found suitable replacement medication. Thanks!

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Stacy Says:
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Zee zee (# 12) --

Just a little info for anyone taking this. I started it about a year ago. It took a few months to kick in. But if you can handle the wait time. It could help you...but everyone's different. Also my doctor made me stop cold turkey 2 days ago until I can get my blood pressure back on track. I was devastated. So far I am having bad headaches and body aches. I'm hoping I get back on it soon. It took a while bit it did help

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me Says:

Greg (# 4) --

my experience sounds exactly like yours...i am also going to stop...but get dizzy when i went from 10mg to 5 mg...don't know what to do...it has made me feel more depressed than I have ever felt in my life

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usurpossum Says:
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Zee zee (# 12) --

I just stopped Trintellix. I've gained at least 10 pounds over the 3 or 4 months on it. When I told my psych I was gaining weight, she attributed it to this med. I believe last night was my last pill. Maybe it's my imagination, but I feel like my heart is racing today. I can only hope my Ambien and muscle relaxer will help me sleep and it will pass. I'll try to post again...if I find my way back to the board.

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Joshsgirl Says:

usurpossum (# 15) --

I just stopped it a week ago and I have been dealing with my heart racing and I feel weirdly tingly all over. So far that is the only sypmtoms I have. I would love to know how long this lasts though....this feeling is for the birds....

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Nila Says:
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usurpossum (# 15) --

I have been on this med for a year and feel like my depression and anxiety are worse recently. Also have insomnia that is worsened on this med. Side effects of wt gain, sweating and itchiness as well. I tapered my dose now to 10 mg. It's been about 6 days and experiencing muscle cramps in hands and feet. Plan on taking every second day now. Hopefully this will subside.

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JUDY 18 Says:

Click (# 5) --

after all these months...how are you feeling now...

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Kali Says:
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Nila (# 17) --

I am off of trintellix for the first time in at least 2 years. A lot of your side effects especially the insomnia have been really difficult - how are you feeling off it now? I’m cautiously optimistic aside from the lack of sleep so far.

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Nicola Says:
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Joshsgirl (# 16) --

Omg joshsgirl, you're the only other person I know that's felt the tingling all over (strange sensation). I'm currently on day 16, first week on 10 then 2nd week on 5mg and then stop. This is day 2 with no brintellix and still feel like s*** however it could also be side effects of starting seroquel.

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