Belladonna-phenobarbital And Norco

Kim Says:
Wed, Jul 20 '11, 8:46 PM

Is it safe to take Belladonna-Phenobarbital liquid prescription with my norco prescription?

David Says:
Mon, Dec 26 '11, 3:16 PM
Hi Kim,

There are actually a few moderately unsafe interactions found between Norco + Belladonna-Phenobarbital that are listed below:

"Acetaminophen + Phenobarbital"
-Barbiturates may increase the hepatotoxic potential of acetaminophen and decrease its therapeutic effects. This interaction is of greatest concern in cases of acetaminophen overdose.

"Phenobarbital + Hydrocodone"
-Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

"Belladonna + Hydrocodone"
-Coadministration of narcotic analgesics with anticholinergic agents may result in additive central nervous system (CNS) and gastrointestinal (GI) adverse effects, and increase the risk of severe constipation or paralytic ileus and CNS depression.

"Acetaminophen + Belladonna"
-Anticholinergic agents may delay and/or decrease the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying. However, the clinical relevance is probably minimal.

That said, I personally wouldn't deem it safe to take these drugs together, but if you do, make sure you notify you doctor so he can monitor you if anything goes wrong.

I hope this helps!