Avoiding Seroquel Drug Interactions

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Go Away Parkinsons Says:

My Mum is diagnosed Parkinsons Dimentia or Lewy Body Dementia. She has been prescribed and has been taking low dose Seroquel (25mg) which dose has been dropped to 12.5mg approx 6 weeks ago. The drugs Mum is on aren't working for her (she is very sensitive to Benzo lines and other drugs) and I'm discussing with her Doctor the feasibility of switching to cholinesterase inhibitor drugs instead. Rivastignmine (Exelon) is one of those drugs but I note it does moderately interact with Seroquel. As Mum is incredibly sensitive to drugs and their effects, I'd rather Mum be completely off Seroquel before commencing something such as Rivastignmine. What period of time would be a safe duration to suggest that the Seroquel would no longer be in her system?

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Verwon Says:

Approximately 36 hours, but it would likely be best for her to take a few days off of it to be certain.

What has the doctor advised about her stopping it?

Will you be replacing it with anything else?

The U.S. databases don't list Rivastigmine as interactive with Seroquel, at all.

Side effects to Rivastigmine may include nausea, diarrhea. dizziness and headache.

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Go Away Parkinsons Says:

Thank you for your reply. Reasons for withdrawing from Seroquel was because instead of preventing her periods of anxiety, it would cause a small period of confusion and then cause her to sleep. For the majority of the day, the effect was merely drug-induced sleep. Mum complained of the constant tiredness and feeling "as though her eye-balls would fall out".

Escipalotram was introduced in favour of Seroquel, but not found effective (and side-effects apparent). This is currently also being weaned off.

Rivastigmine (or "Elexon", as it is named here) patch medication has recently been commenced.

Since these changes, periods of alertness, wakefulness, ability to vocally communicate noticeably increased. Periods of anxiety still proved a problem, however these appeared to be somewhat (albeit slightly) further between than before. Unfortunately, monitoring with reliability has been interrupted due to a recent fall, causing Mum to break her hip which has subsequently received surgery (partial hip replacement). The shock and pain, change of environment, fear of the surgery, sudden (further) loss of independence as a result of absence of free ambulation etc. have all had an impact on anxious behaviour and I'm working on trying to steady Mum back to a base-line where monitoring for positive/negative signs of new medication regime may resume.

More time required, but considering conversing with her Doctor about the inclusion of "Namenda" (Memantine) in tandem with current Elexon medication.

From readings, these medications are useful in cases of mild to moderate PD and DLB. Mum is considered "severe", however she has shown to be exceptionally sensitive to the SSRI drugs already tried, I am hoping these drugs may be sufficiently effective for her.

Also considering use of natural medication "Kavva" to trial - plans are to commence this once Mum is weaned off the Escipalotram. Tinkering also with the idea of adding Huperzine A, but need more time and more self-research to see how things settle in before going there.

Thoughts? Comments very welcomed.

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Go Away Parkinsons Says:

I forgot to add that whilst Mum is weaning of Escipalotram, "Alprazolam" is being used (half of lowest dosage) as a PRN to bouts of anxiety that cannot be resolved else wise. We are not using the Kavva until weaned off from Escipalotram as Kavva can interact with Escipalotram.

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