i am tring to find out why my husband was on these as a child he was a bleeder on the brain and was also on papaverine 150 i found what they are for but cant find what the Arlidin are for he is a little slow and is 43 years old and is fully deaf i have these two prescription here that his parents never gotten filled from back in 1979 so can you help me on this thank you
ARLIDIN® (nylidrin hydrochloride) acts predominantly by beta-receptor stimulation. Beta stimulation with nylidrin has been demonstrated in a variety of isolated tissues from rabbits, guinea pigs and dogs. It has been shown to dilate arterioles in skeletal muscle and to increase cardiac output in the anesthetized dog and cat and in unanesthetized man. An increase in cerebral blood flow and a decrease in vascular resistance has also been reported. The result of this combination of actions is a greater blood supply to ischemic tissues, with usuallyminimal change in blood pressure.
The mechanism whereby nylidrin may provide relief of selected symptoms in some elderly patients with organic brain disorders is not known.
INDICATIONS and CLINICAL USE
ARLIDIN® (nylidrin hydrochloride) may be of benefit in elderly patients with mild to moderate symptoms that are commonly associated with organic mental disorders. Short-term (3 months’ duration) and long-term (12 months’ duration) clinical studies have demonstrated a modest improvement in ability to perform general activities of daily living, self-care and in a capability for social interactions.
Although the patients appeared to be less confused, more alert, and more aware of their surroundings, an objective improvement in cognitive function has not been quantitatively determined.
In peripheral vascular disorders, ARLIDIN® (nylidrin HCl) increases walking ability and promotes healing of trophic ulcers associated with :
- arteriosclerosis obliterans
- thromboangiitis obliterans (Buerger’s disease)
- diabetic vascular disease
- night leg cramp, Raynaud’s phenomenon
- ischemic ulcers
- frost bite
ARLIDIN® has been shown to be of possible benefit in the above peripheral vascular disorders. While improvement does occur in advanced cases, experience has shown that the better the condition of the vascular bed the greater the degree of early therapeutic benefit from ARLIDIN®.
Acute myocardial infarctions, paroxysmal tachycardia, progressive angina pectoris and thyrotoxicosis.
WARNINGS and PRECAUTIONS
Medication with ARLIDIN® should not be initiated before a careful diagnosis of chronic organic brain syndrome or organic mental disorder is established since it is essential to identify the many treatable or reversible conditions or mental changes in those patients that will benefit from specific therapy.
Among the most common causes of reversible or treatable organic mental disorders are drug-induced mental changes and those due to alcohol, metabolic imbalances, nutritional deficiencies, hepatic cardiovascular and pulmonary conditions, trauma, tumors and particularly depressive and other emotional disorders.
ARLIDIN is not indicated in the management of normal aging or of patients with pre-senile dementia (Alzheimer’s Disease).
The safety of use of ARLIDIN during pregnancy and lactation has not been established; therefore, it should not be administered to women of child-bearing potential, unless in the opinion of the physician, the expected benefit to the patient outweighs the potential hazard to the fetus.
In patients with cardiac disease such as tachyarrhythmias and uncompensated congestive heart failure the benefit to risk ratio should be weighed prior to therapy and reassessed periodically during treatments.
Trembling, nervousness, weakness, dizziness (not associated with labyrinthine artery insufficiency), palpitations, nausea and vomiting may occur. Postural hypotension and allergic manifestations may also occur.
SYMPTOMS and TREATMENT OF OVERDOSAGE
Transient headache, flushing, shortness of breath, palpitation, or increased cardiac awareness, sinus tachycardia, transient loss of diastolic pressure and transient non-radiating chest pain.
Administer mild sedative or beta blocking drug titrated against cardiovascular response.
DOSAGE and ADMINISTRATION
The recommended dose range for relief of manifestations of peripheral vascular disorders is 12-48 mg/day given in 3-4 divided doses.
The recommended dose range for relief of selected symptoms in patients with organic mental disorders is 12-24 mg/day in 3-4 divided doses.
ARLIDIN® Tablets, 6 mg: Each round, white tablet, 6.4 mm wide biconvex, 2.5 mm high, imprinted with “A” in shield, bisected one side, contains 6 mg nylidrin HCl. Available in bottles of 100 tablets.
CHEMISTRY and PHARMACOLOGY
The chemical name of nylidrin hydrochloride is : p-hydroxy-a- [1[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl-alcohol.
Experimental studies in animals and humans show ARLIDIN® (nylidrin hydrochloride) to have a direct vasodilating action selectively upon the small arteries and arterioles of skeletal muscle, with relaxation of the muscle fibers in the media of the vessel wall. It also increases cardiac output (minute stroke volume). The effects on pulse rate and blood pressure are minimal as are untoward effects.
In a comparative study of the effect of various vasodilators on blood flow to the muscle and skin, Hensel and colleagues found that ARLIDIN 5 mg intravenously “caused the greatest increase in muscle blood flow to about 200 percent of the resting value, whereby skin blood slow remained practically unchanged”.
Stein demonstrated plethysmographically in 35 patients with occlusive arterial disease disease that intra-arterial injection of single doses of 6 mg ARLIDIN produced a marked increase in blood flow in the calf muscle. This increase ranged from 200 to 800 percent and depended upon the vascular reserve present. The average was a 300 to 400 percent increase which lasted for several hours. It is Stein’s opinion that the absence of skin flush in the presence of a tremendous increase in blood flow to muscle indicates that the site of action is predominantly the skeletal muscle blood vessels rather than those of the skin.
Powers measured the alteration in blood following intra-arterial injection of ARLIDIN (nylidrin HCl) in 20 patients with peripheral arterial insufficiency. “A rather striking increase in blood flow in the majority of patients”occurred following injection of 5 mg in the femoral artery and “indicated that this drug will produce significant vasodilation of the muscle bed in patients with disease involving the major arteries and where intermittent claudication is the principal complaint”.
De Crinis, et al. were able to demonstrate by plethysmography that ARLIDIN® increases blood flow in muscle beyond that produced physiogically by exercise. They tested the blood flow response to exercise in ten subjects (three healthy and seven with a diagnosis of occlusive vascular disease of the lower extremities) before and after intravenous administration of the drug. They found an average increase in peripheral flow of 65.5% after exercise and of 112.6% after exercise and ARLIDIN®. ARLIDIN® thus produced and additional increase in blood flow of 47.1% over exercise alone. The surface temperature was essentially the same after exercise with or without the drug. Other vasodilating drugs which are sympatholytic agents, tested in the same way, produced negligible additional rise in blood flow rate in muscle in response to exercise, while surface temperature showed a significant increase.
® Registred Trademark of Aventis Group. Used under license by ERFA Canada Inc. Westmount, Quebec H3Z 1E8
Sorry, I didn't mean to copy the whole thing but I didn't know how to cut and paste the name where you could go back into and retrieve it. Hope this helps.
sorry zippysgoddes....I didnt know you had already done it the RIGHT way.
LOL! Not a problem, you can't use cut and paste by itself to do it the way I did, you have to use the HTML I told you about with the cut and paste.
Makes sense, I am a very slow learner when it comes to cut and paste and doing it through hotmail.
Did you mean HTML? If so, that is not hotmail, that is Hypertext Transfer Protocol, that is what makes links, images, etc. usable and clickable on the internet.
Don't need hotmail to do it, just type or paste in the stuff I sent you in the email.
HTML is the basic form that the internet is created from, though there are others that are also used. But it makes the links compatibile with all browsers.
Shows you how little I know about cutting and pasting! My daughter usually has to help me. I am a 100% auditory learner (was tested and actually scored as being 98%). It is hard when most of the world are 50% auditory and 50% visual, give or take 10% each way!
OOps, guess we need to talk on the phone sometime, or I need to send you a tape recording. I am actually more on the visual side, I would rather see things first hand or read them myself to learn, rather than listen to someone explain it or sit through a lecture. So I actually do better with at home learning on my own. Andy is more in the middle, and he can handle a balance of both, so he does great in his college classes, he has a 3.9 grade average and made Provost Scholar in his junior year.
Good for him! I had it rough in college. I was taking care of my nephew who was 3 weeks old, taking 19 credits per semester, (I figured that if I was paying for school myself then I was taking the maximum amount of credits possible), and working 60 hours per week. I raised my nephew by myself for 3 years before my brother and sister-in-law came back around, got it together and took him back. I had to work 60 hours a week to make ends meet. Believe it or not I graduated with a 3.89 gpa. I think working hard in everything I had to do just made me thrive. Now I'm too old to do all of that! I have 15 siblings and none of them went to college, masters, Phd, or even did anything constructive with their lives except for maybe 1. I don't bother with them much. Been on my own since I was 16 and had a better life because I had social workers and teachers and friends who believed in me. I think it was a good move.
Have a good one!