Anybody Else Get Hives After Linzess?

Brenda Says:

Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared about half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms?

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Verwon Says:

Hello, Brenda! How are you? I'm very sorry about the problems you've had with this medication.

Some people have been known to be hypersensitive to this medication, so that may be what you experienced.

Alternatively, as listed by the FDA, hives can also be a side effects, as well as sinusitis, headache and dizziness.

Has anyone else experience this?

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SG Says:

Hi, I've been having the same issues. Started taking linzess in April and have noticed my sinuses and allergies have gotten worse. In addition, I have broken out in a horrible rash on my face. I've tried Cortizone and Benedryl cream which both work but if I stop it gets worse and spreads. It looks like poison ivy reaction. I thought it was rosacea (which I've never had) but have noticed it's been since starting linzess. Is this normal? And should I call doc? I do have diarreah and occasional cramping but all other side effects (dizziness and nausea have subsided).

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Kay Says:

I started taking Lizness about 1 week ago. Only took about 2 pills on Friday and Monday. I have bad hive all over my body when I noticed that when I atd fruit snacks I would start itching all over withing 5 mins of eating them. Its now 12:29 in the morning June 27 and been off eating fruit snack and my hand is noe itching and breaking out again. I did eat hamburger helper about 9:30pm. I think I need to keep a dairy on me.

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maegj Says:

Hello. I got this script on June 11th. Took 2 pills the 1st night because I am so constipated all the time. Within a few hours, I was literally blowing up the toilet & it lasted for several hours. I thought maybe because I took 2. I continued to take 1 upon waking & same thing every time. Nothing but runny stools for several hours & I cannot leave the house. I also noticed severe bloating afterwards & weight gain. I feel miserable the rest of the day. I have also been feeling shortness of breath & my sinus problems which are horrible anyway, have gotten way worse. I will not take this medication again. If I want to have explosions for several hours, I can drink some milk of magnesium without the other symptoms. I thought I had found cure to my horrible constipation but I would rather stay that way then to have these side effects. Now I am back to trying to find something else. Sighhh!

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kay Says:

Hi, try to take 1 pill and skip a day and take 1 again. I really love the pills but noticed that with certain foods I have to not eat with it. So I keep a food diary on when I took the pill and what I ate and if I had any allergic reactions or not. Plus I called my doctor when I started breaking out and she said that the pills should break me out because it normally starts after 4 days taking the pills. I do understand some people are different when it comes to taking meds. It does sound like you make be allergic to it with having to go to the bathroom all day. It only does me like that about 1 hour after taking it. I take it about 30mins or an hour before I eat. After I eat Ican feel my stomach rumbling and making noise and then I know its time to go to the bathroom. Hope it gets better

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maegj Says:

I did try that Kay. It's not getting any better. It has caused me more problems than solutions. This is the only new med I have started & didn't even think it could cause me so many problems. I took the last one i will ever take Friday I believe. I hope this gets out of my body soon & I will know for sure this has been causing all my problems lately. Thank you & good luck

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FLO Says:

I'm not allergic to it. Life altering for me. Had to go to 290mg. But I also started taking Nortriptoline Mar. 8 and it caused my constipation and sometimes Linzess causes constipation not always. So the two together work great. FYI I'm taking nortriptoline for the abdomen and calf pain. Was awful. From Dec 2014 to 3-8-15 wanted to die. The pain was horrid!!! Horrid!!! Sorry you are allergic. Bummer. Maybe try Amitiza.

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Anna Says:

Going to stop linzess .. Having worse than normal even odd congestion, wheezing and tightness in chest. Urgent care dr said it was most likely bronchitis and prescribed steroid shot and antibiotics, well.. That was two weeks ago and still sick. Stopping linzess

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FLO Says:

EXTREME FATIGUE. EXTREME. ALSO I TAKE Nortriptoline. Diarhea if taken with meals. Don't go if taken b4 meals. Might try 5 mins b4 I eat. But bottom line I'm much better on Linzess and nortriptoline. But it's SO HARD TO WORK. can't take off own my own business.

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Boomdia Says:

I started on the higher dose in December. Two weeks later I was having diahrea ( I was heading to work and no rest stop with 20 mins ). Needles to say I had cleaned myself up and went and bought new cloths to go to work in. They lowered my dose to 145. Today on my way home from work I started feeling really ill. Like I was going to throw up then it settled then thought I had to go accompanied by bad dizzy spells. I was able to get home this time. I have 2 "normal " bathroom issues the rest has been diahrea. I have gone online and come to find out that if you are expierencing diahrea while on this treatment it says to stop and call dr emmidialy. Has anyone else had this?

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yes Says:

took 145mg this morning at 7:00am
have had diarrhea all day?
not what I was looking for.

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MikeR Says:

Having a problem with constipation at the end of the day after Linzess in the AM continuing into early AM next day until I take my next dose (145mg). Wish there was a way to take it without a constipation chaser each evening. It's much like what happens when u take Milk of Magnesia - next day is constipated in reaction to the magnesium and loose bowels. Any recommendations?

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Stephanie Says:

I have been on it for about a week now and the past two days my whole body has broken out in hives. Nothing I take seems to help. I didn't realize it was medicine until I looked up the side effects. Sadly, this was really helping my constipation but now I will have to stop taking it because I can't focus on anything right now because I can't stop scratching all the time. I am stopping the meds tonight and see whay happens in the next 24 to 48 hours if I dont get better I will be visiting my Dr.

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Ckrm Says:

I took one sample capsule eight days ago. Within 25 minutes I have explosive diarrhea. Eight day gone and still have extreme abdominal pain cramping and diarrhea. Have been in contact with doc office. "Continue on medication." No, I never took another. Still suffering.

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Ckrm Says:

I took 1 Linzess capsule sample from my gastro doctor 4 weeks ago. I have had diarrhea and cramping since. That is the result of only 1 capsule 4 weeks of not eating much, drinking water. When will this stop.

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Sandra Says:

I was on the 290 and it caused diareaha really bad, then the doctor put me on 145 with a stool softener a day, and I have been walking over two miles a day now and drink 5-7 20oz bottles of water a day and watching what I am on day 8 I still have not had a bowl movement, and that is on top of two suppositories....please help...what do I do next.

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Vickie Says:

I am having trouble with watery bowels all the time when I take this. Lasts for days. Took one last Wednesday and Thursday had an accident in a store. Thank God for papertowels because I had it everywhere including my clothes. Have had several cases of very watery stool including today, 4 days after taking it.

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Kate Says:

Well, this might be an older post but I was looking for help but I can say that THIS is the reason I started searching for a blog. 8 have been on Linzess 290 since November 2015 so 10 months everyday. Each morning must be planned out in advance so I have time to go to bathroom before leaving house. My dr told me originally take dose in am wait 45 min then eat but then she told me to try taking the pill as soon as I woke up and waiting 30 minutes to eat and hopefully the diarrhea would stop. Apparently most people it stops after a month. Not I though. Every morning it is the same thing within an hour of eating. I have added apple pectin (fiber) and magnesium in hopes of the severe daily episodes of diarrhea going away but here I am 10 months later. The fiber helps I think and so does eating things like oatmeal for breakfast. I hope you find something that works but I am searching now for blogs for the same reason. Good luck!

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Jarjar Says:

Nobody is talking about gas I've been on this med linzess for a few months and I have the worst gas with stomach bloat any ideas as to what to do

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Tom Says:

I just started Linzess a short time ago 290mcg. Took 2 a day first two days then one daily by dr. direction first few times fast, loose b.m.'s. Missed day and took at 9or 10 o'clock, up at 2:00 took a second and a third at 5;30 because of large hard very difficult movement. Required physical assist to remove. I am scared now because I have taken too much without realizing it. Hope and pray I will be o.k. Med. seems to have stopped working.

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