Abuse Deterrent Xtampza Vs. Oxycontin (Page 3)

Newly FDA approved Xtampza ER has a different abuse deterent additive than Oxycontin, however I have not tried it yet for effectiveness. I have taken Oxycontin over 10 years so I felt the huge difference when they began adding abuse additive to it. I am curious if anyone has info on this new med, how it works as compared to Oxycontin, or all info on it that may help me decide if I should switch? I always had excellent results with Oxycontin but when the abuse stuff was started it took so much away from effectiveness. Appreciate any info. Thanks.

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Re: Retired Nurse helper PT to others (# 33)

I can understand your frustrations on how you're going to make the switch to Xtampza er especially since it's being forced on you starting on the first of the year. Just a really short explanation on how I got to this point. I was referred to a pain mgt. group to deal with opioid rx's. They started me out on 4 5mg pills a day. Progressed to 7.5. My primary said to ask about going on er to make sure I got the 4 pills in every day. They agreed. Started 13.5. Upped to 18. Sorry, I can't make anything short. What got me on this site was questioning what food and how much to take. Have learned a lot by just reading all these posts. The most helpful thing I've picked up is from Mr. Ryan on another group also on this site. Only way I know to tell you how to find his posts is to search Xtampza er at the top and scroll down to the left where it points you to 80+ posts and scroll till you find him. He goes into such detail on his story and what he has found that works for him. His trick is to set his alarm for 3:00 am, eats a bit, takes his pill, then goes back to sleep til 5:00 when he has to go to work. This gives his pill time to kick in. If you find his posts on the other group you'll get the rest of his story. If you can't find him, give me a shout and I'll try to get you there. Personally, I have my pill, snack and drink right next to my bed and follow what he does. Like you, I can't move first thing. One thing I will tell you, in case you don't know, is that Xtampza er does not have acetaminophen in it. I take some with my first dose of Xtampza. I think this kicks in pretty quickly so that might help. I wish I could tell you what magic would help. Read up on anything you can find on this site. You'll get a lot of ideas you never thought of and can explore on your own. I'm not the sharpest knife in the drawer so I have read over this stuff numerous times and am still learning. I encourage you to work with your prescriber until you get it worked out. Don't be afraid to talk to them. If you don't, they won't know that you need help. So much for keeping it short, huh? Hope you'll check back with your progress. Best of luck!

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Part of the effectiveness of opioids is that they change your brains perception of pain so when they put something in it to change that aspect it isn't going to work as well. Opioids do not do anything for pain in the aspect of affecting the nerve or reducing inflammation. They work by working on the chemical receptors in your brain and changing how it deals with the pain signals coming into the brain. The euphoria you feel is part of that medication working. When it's reduced so is the effectiveness.

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More people die every year from diabetes, heart disease, and cancer than from opioid deaths. From my research, to date I'm sure that there are many other types of comparisons that can be made. How about someone else come up with some stats on how many of those were from legally prescribed meds to the patients that they were prescribed to Vs. illicit drugs or if the person had been using unprescribed meds to try to get more relief after having had their "medical professionals" cut them off, while still in pain verified by other Doctors, diagnostics/evaluations by mental health professionals. I've got unfortunately more time on my hands from my last surgery a month ago to further follow up on while waiting to recuperate for the next of at least 2 more surgical procedures to look forward to. I know of one individual, personally, that couldn't handle the pain. The begging & fighting between his Doctors and on verge of losing everything after being cut off from his medications by his insurance company. He took what he felt would be the final end to his pain, suicide. It totally destroyed his family and friends as well. As selfish as I can only imagine he felt, he ran out of options. He was a good husband, father to his children, and friend. It bothers me to my core to have to share this at all. I know that there are plenty of junkies out there who blew all their bridges "chasing the Dragon". He wasn't one of them, he couldn't bear for his loved ones to go through it anymore. I don't recall too many eulogies putting that heartwrenching stuff into the obituaries of the people they Loved in Life, and lost them. Unfortunately, he is now just another number to these statistics that will only continue to rise. Very Sincerely. Just one more statistic to open the eyes of "those people" running our pitiful healthcare system. What stigma is left behind for the poor families and friends that they have left behind. Congratulations to our state reps right up to the FDA & DEA for protecting those most dearest to us. Are they just too stupid or just do not care about we the little people who still have the luxury of friends and family to stand by us through all of this?

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Re: Verwon (# 1)

I have used Xtamza since it came out and have been in the health care field, specifically pharmaceuticals about 35 years. I do know a little about pharmacology and half life. Oxycontin is NOT a twice a day medication, never will be. It's half life is too short. But because it is an opioid, that's what we're stuck with. Xtamza has a half life of a little over 10 hours where Oxycontin is 4-6. It lasts much longer, is fairly gentle, and have been very satisfied with the pain relief. The problem is you have to take an IR medication for immediate relief. It takes several hours to reach peak blood levels and doesn't relieve tough severe pain straight away, if at all. It keeps the blood levels up so it does help and you can tell when it is wearing off. The problem is the next dose takes a while and there are gaps where you need an IR complement. Hope this helps.

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Re: Phil (# 44)

Phil is that in same family as hydrocodone and oxycodone? What I mean is I get hives and the meds for lupus started making my stomach bleed plus I got sphincter of oddi disfuction after gallbladder surgery that went wrong . I found I couldn't take dilaudid but could take low dose morphine but they switched it to IR and for some reason on bad days it wears off in 4-6 hours . Do you think the new drug you said was gentle might work or could I still have that same allergic reaction ? It seems everything even patches I was allergic to so right now I'm paying attention to these forums and trying to educate myself Bc I feel so lost with this incurable disease ! Thanks

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Re: Ktb (# 45)

Xtampza is oxycodone with a different delivery system. So if someone is allergic to oxycodone then this would not be the drug for them. Also the half life of oxycontin is 4.5 to 5 hours but that is only when half the drug is metabolized and it is at its peak. So it would take another 5 hours to be completely metabolized. That means that thus drug is a twice a day medication as the manufacturer and the physicians state. Now every body is different and some may get rid of the drug faster or slower than the average. I have seen it written for 3 times a day before but no more than that. From what I have heard and read about xtampza has about the same half life but seems to take effect quicker than the oxycontin and may stay around a little longer. Obviously, the main difference is that the oxycontin is a tablet that has to release slowly whereas the xtampza is a capsule with small abuse deterrent beads inside that release the medication in a small amount at a time. The beads are different sizes that metabolize at different times. I personally would prefer the xtampza delivery vs the oxycontin delivery but both are made for twice-daily dosing.

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Been on OxyContin for 18 years now. In the old day's I was getting 120 mg when they first came out! Then only 80 mg, then tamper proof in late 2009 which were no where near as good! Now this! Been on almost everything, Fentora which by the way was the best (GREAT) however, after 2.5 years at a cost of $5,000K for 121 doses per month, Busted Cross & Broken Shield declined to cover any longer. Their reason was that the pain wasn't derived from Cancer! This may help some people in FL with legit pain! BCBS of FL will cover OxyContin with prior auth. until 04/1/2018. That may give u more time to find another Provider. In addition, they will still cover Oxycodone with prior auth. Simply put, I will seek an alternative to Xtampza. I'm the only one that can say what helps me deal with my Handicap, not the insurance company or the Gov!

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Really agitated right shoulder Oxycontin guy (# 43) --

I'm on a roll tonight. Yup, very sorry to point this one out, please don't take offense Kenny Kane. I actually lived in Jax Beach for a time back in the 80s. Supposedly met one of dudes from Skynrd, not sure if I was being goofed on, met a lot of characters while I was down there. This was one of the states where the "pill mills" originated, as far as my research shows. Once again greed of a medical "professional". I believe it was DEA that finally got him, but not before his greed messed a lot of people up. Now people are getting fentanyl from China. Another thing, up around here it's been a big problem of late. As messed up as it sounds, yet another bit of my research. Drug dealer was shown bagging up his illicit drugs for street sales, with whatever particular stamp he put on his packages. That's for "marketing" purposes, they pretty much all do it. New twist, I hadn't seen this seen this one until earlier this year. He would randomly pick out a package for the street sales, and put enough fentanyl in it to cause an overdose. Like I stated, rest was straight up illicit drugs. Once people get to that point in their, I'll say spiral (I hate seeing & talking about this stuff, but I feel it needs to be put out there). Please don't take it as me judging anyone. When the cash is flowing in every dirtbag wants there blood money. Whether they are street dealers or the ones wearing their white coats in a nice comphy setup with secretaries greeting & scheduling. I'll get this stuff off my chest before I have to lay down and look at the clock. While dwelling, I refer to it as my thoughts "rat racing". Like with gerbils in their cages, going round & round on their spinning wheels. I say "rat racing" because it just seems to be more fitting. Feels like another uncomfortable sleepless night coming on. Just putting it out there for others in this forum THAT CAN RELATE TO EXACTLY, maybe not using my rat analogy, WHAT IM TALKING (more like rambling to me) TALKING ABOUT. Would ranting seem more appropriate? Thanks for "listening". My regards to all.

Sorry - I just checked out one of my posts from the 10th. I got a statement backwards. More people die from the pain meds than those other combined. My apologies. Always try to correct any of my stuff if I've screwed something up.

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Re: Phil (# 44)

Thanks for the info. I'm not sure if I like the sound of that though. It seems it could be a little confusing if I were put on Xtamza as opposed to the 10 mg. of Oxycodone I take every five hours. How would I know if I'm getting too much oxy using Xtamza and the quick release less often?
Does that make sense?

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Xtapza er 13.5 seemed about the same as OXy 10 er, but caused occasional nausea problems. Was increased to 18 mg and can't stop puking. Taking two OXy 10 at a time never did this. Also, did not seem to be equilivant, but slightly less. (Ymmv). Have been on OXy for over 20 years, both er and ir, and had two surgerys so far. More recomended.

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Re: Dan (# 16)

I agree. I took morphine at 100mg 3xday for years. I have cerebral palsy w/spina bifida, multiple sclerosis and Lupus. When I was on that amount I could manage my dose depending on my pain, I rarely took more than 200mg. I worked as a public law paralegal, did my own housework, gardened. rode my horse etc. Now after being "cut-off" for years after the FDA quidelines that frightened all the dr.'s and insurance companies, I only get 15 mg.s 3x a day. I don't even feel it. They tried to put me on methadone, which is a very dangerous drug, and tramadol which does nothing, and I refused. They wanted to do spinal blocks. I can't do that due to an autoimmune blood clotting disorder for which I have to take warfarin. They have tried to replace morphine and like drugs with methadone and others that are dangerous and don't work as well. All to appease the FDA and DEA. I am 64 and they say they don't want me to be a drug addict. How ridiculous. My time is limited due to my diseases which have cased permanent organ damage. Taking too much anti-inflammatories because I couldn't get morphine has caused kidney failure. The other "neuroleptics" and drugs that are supposed to help pain have terrible side-effects and don't work well for my diseases. I have been through all of them. We need to get the govt. out of our pain control. Every person should be evaluated on a case-by-case basis. We aren't gutter hypes. Pain kills.

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Re: Markemark (# 4)

I tried xtampza 18mg for the ER aspect 2x daily for 1 month. I was taking 6 to 7 10 mg oxycodone for several years and I was becoming tolerant. I have a bad diagnosis of degenerative disc disease which I will need fusion from bottom of Cervical to tail bone I am going to be 47. The xtampza is the worst medication I have ever taken. It has 23 side effects to include back and muscle pain which makes no sense. I got no relief none whatsoever. I think the FDA rushed this to appease the judging public. My meds were changed to 20mg oxycontin ER 2x and 20 mg oxycodone for breakthrough pain. That is working. People who need these to just survive should not be judged or kept from what they need because the popular opinion of anyone who takes these meds is a junkie. I have almost taken my own life to relieve the pain. The psychological aspect of chronic pain is often overlooked unfortunately. Sorry I rambled. Xtampza is horrible and was created to make people who don't need them feel like they are doing something. That is BULL S***!!!

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I was on 40mg of oxycontin , 3 times a day. I was switched to xtampza er 36. I like most see abuse deterrent and thought would be weak. WRONG! If you do not abuse or even if on oxycontin since 1996 this formulation is strong like the 1st ones to come out. Purdue is suing the makers for billions in fact for infringement. They are twice as efficient as the O.P.'s. There bio-availability is 89% on empty stomach as opposed to 67% in OP's. This is from an independent lab. Most insurances cover or will with p.a.

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Re: Beagle mom (# 26)

Im curious about who ur pain doc is. I live in south florida.

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Re: Markemark (# 4)

Good to hear as I have been on 20mg ext release plastic for ten years and just got prescribed Xtampza. From what I’ve read, the 20mg oxy ext release I’ve taken all these years, gets digested before all the medicine gets into your system but, with Xtampza, your supposed to get close to 100%. I’m looking forward to taking them and I’ll let everyone know how it goes!

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Re: Kris (# 55)

I just started xstampa 27mg. 4 per day. I was on oxycotin 60mg 3 x a day. The xstampa does NOT WORK AS WELL. Supposively u must eat high fat foods to make it more effective. I dont eat high fat foods for health reasons. I wish i could go back to oxycotin.

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Re: Markemark (# 4)


To the makers of XTAMPZA ER, the new opiate deterrant pain medication recommended by my pain control doctor *KENDALL HANSEN MD. Founder of INTERVENTIONAL PAIN SPECIALIST of CRESTVIEW HILLS KY. Xtampza ER is wonderful. I was prescribed oxycontin 30s for a miserable chronic pre-existing back and spinal conditions. Also I have an Astrocytoma (probably spelled that wrong as well, sorry) in my right frontal lobe a miserable painful brain tumor causing excruciating migraines.I also was diagnosed with epilepsy (severe extreme grandma seizures) which can cause painful migraines b4 and after a seizure! When DR. HANSEN is performing his back and or spinal shots with his ultrasounds guidance and his knowledgeable medical background, I feel extremely safe and comfortable during my shots i know I'm in very safe hands on his table that even if a seizure was to happen during a procedure then Doctor HANSENS got my back (lol get it? Got my back) offered with or without sedation... lastly, a fashyodemy caused by rabidomaylsis (capartment syndrome), one day i had a severe seizure falling down my steps knocking my self unconscious). I had to have the majority of my right hip muscle removed. Spending 67 days in the ICU learning to walk again shortly after I developed MESSER. I WAS in constant pain and been on every opiate PAIN med out there. From fentanyl 100 mg. patches combined with ms contin, combined with lortab 10s for breakthrough relief! After opanas, morphine, hydromorphone, many more opiates -every single thing and, some all at once, I went to oxycontin IR back years ago and non deterrent OXYS. When opana was discontinued, i was at a loss.

Then finally my current pain control DOCTOR, KENDALL HANSEN MD. (whom btw is a most excellent doctor and started his practice) at INTERVENTIONAL PAIN SPECIALIST, 340 Thomas More PKway Crestview Hills, Ky. 41017 # (859) 957-0700, recommended Xtampza ER, considering a switch (no tapering btw), myself and DR. HANSEN decided to instantly switch from my oxycontin 80 mgs to the new Xtampza ER. After a few dosage adjustments, trial and error (as with most of us opiate, chronic pain med patients), from Fentanyl 100mg patches to opana, to oxycontin, have found the most wonderful newest pain med FOR ME, this XTAMPZA ER on the market to date! As u can well see, as many health issues i have, and serious pain issues for an abuse-deterrent med such as this Xtampza is and, has been such a blessing in my life) ty makers of XTAMPXA ER! As my review here's written i truely am shedding joy of new found relief and comfort for the 1st time in 11 years!!! I'd recommend Xtampza ER to any 1 in chronic long term pain... Hope my story helps... Good luck and give it a try y'all, extremely relieved patient with very minimal current pain to date! Also, if you're a northern ky. Resident or, near us here in northern ky. Check into KENDALL HANSEN MD. at the Interventional pain Specialist. His specialty is in any type of back pain treatments along with the 2 Phenol SI shots, the medication of XTAMPXA ER in combination AGAIN FOR ME WORKED which, may not be for everyone with chronic back pain and opiate pain meds combo was the PERFECT match!!! Ty DR. HANSEN and makers of XTAMPZA ER. Sincerely, Chad H. 36 yr. old Northern Kentucky resident.

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Re: Kenny Kane (# 47)

Im curious what ur research will show. I would like to try something other than xstampa.

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Re: Flormart (# 52)

We need to remember that medications work differently in different people. We metabolize medications differently, so what works for one person may not work for others. Good luck, hope you find relief.

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Re: Axl (# 2)

Time for you to be honest with Yourself before you end up dead. You have a high tolerance because you are abusing and clearly addicted to opiates. The Levels you are taking are extremely highhigh and very dangerous. You may think I'm being judge mental which I am because from your post you have a serious problem. Please seek the help you need.

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