2-pam Chloride (protopam Chloride Or Pralidoxime Chloride) For Injection For Rsd

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Carol S Says:


Can anyone tell me if this has been used for treatment of pain due to RSD
(Reflex Sympathetic Dystrophy) or CRPS (Chronic Regional Pain Syndrome)?

Thanks for your response. Carol S



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Verwon Says:

Hello, Carol! How are you?

I'm not finding anything on it being used for such.

Has your doctor suggested it?

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Carol Says:

No, I haven't been told by a doctor, but I've been researching possible ways to manage this disease for my daughter.

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Carol Skilling RN BSN Says:

No, I'm just following a thought process that possibly my daughter who has Reflex Sympathetic Dystropy, a nerve disease, was exposed to Malathion while she was living in our basement for 6 years with her family. (After a small injury as an EMT, the symptoms of RSD began. A small injury that isn't consistent with the pain of this disease usually signals the diagnosis of RSD. Thermography was also a tool which our daughter had done in the care of Dr. Hooshang Hooshmand, Neurologist in Vero Beach, FL. She also had many nerve blocks which helped her a great deal in treatment of this horrible unrelenting disease over the 15 times we took the trip from Boston. I'll always be grateful to him but unfortunately he is no longer practicing.

The history of RSD goes back to the Crimean War where nerve gas was used. Malathion which I've had on the shelf in the basement for gardening, which could be smelled each time you descended the stairs, has similar properties of nerve gas which affects the cholinesterase. Cholinesterase is the enzyme which stops a nerve from continuing to fire the muscle to make movement. In other words, the nerve activated by acetylcholine is not inhibited by the blocked cholinesterase because of the exposure to Malathion. and that is how I believe, may start an RSD problem. This is just a thought process--trying to combine my education in Anatomy and Physiology and the history of RSD disease. I just recently removed this Malathion from my cellar stair shelf and was amazed at how the odor we've been smelling for years was suddenly gone, so I proceeded to read about this Nerve agent. This insecticide is used in Lice treatments and is also used in pest control in the garden. It is an organophosphate insecticide that binds to the enzyme acetylcholinesterase (AChE) at nerve endings throughout the bodies of insects and other organisms. Under normal circumstances, AChE binds to the neurotransmitter Acetylcholine (AChe) at the nerve junction, effectively ending the stimulation of the next neuron. When AChe is bound by Malathion's metabolite, Malaoxin, ACh accumulates at the nerve junction in overstimulation of the nervous system. Doesn't that sound like RSD?

This information was obtained from the NPIC/Pesticide Information on line, or 1-800-858-7378. Other information was gleaned from PubMed Commons. Wikipedia also has information about "Nerve agents."

Antidote Protopam Chloride (pralidoxime chloride) is a CHOLINESTERASE REACTIVATOR. So to recap, this drug was my question in the use of RSD.

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