Trintellix

Hi everyone! I have been diagnosed OCD in the past and now I have been prescribed Trintellix to treat my depression symptoms which seems to have worsen by the COVID-19 pandemic, all the strict measures because of the virus and challenging life implications. I am on my 5th day taking Brintellix on a 10mg dose. On this 5th day with Trintellix I am feeling a very slightly better in my mood overall, kind of calmer and relaxed, but so far I have not experienced such a big difference overall. Thank God I have not felt any serious side effect such as nausea, vomiting, or constipation; which was one of my main concerns about the usage of this drug, since many patients that are on it report such side effects as common. My question to anyone out there is if by having the same or a similar diagnos...

Why did I read that you should not take this medicine till 2020? I was just given a lot of samples of 5mg that my doctor wants me to start for my depression. I am scared to death to start because of the horrible reviews & side effects that sound horrible. I have never heard of this drug. Can you please help me with this. Also if I do decide to start when is the very best time to take it? ## Has anyone else gone down from 10 to 5 mg of trintellix? I am afraid I will have some anxiety doing this. Can anyone give me advice? ## I've been on Brintellix/ Trintellix for going on 2 years. Saved my life. I am on a low dose, with buspar piggy back, but no longer a handful of drugs. If you've failed the rest, give it a shot. Start low. I am great on just 10mg, and I was suffering from ...

23 REPLIES

Tapering off of Cymbalta and starting 10 mg of Trintellix for 7 days soon to increase to 20 mg. I have suffered with Major Depressive Disorder for 23 years. Tried so many antidepressants and settled with Cymbalta. Take Abilify 20 mg. No side effects so far. Seem to have less fatigue, more energy and increased ability to focus. I have ADD and take 70 mg Vyvanse. Overall, very pleased with Trintellix. I can honestly say this was a Godsend. My family has noticed a difference in me already. Amazing drug well worth the high cost. Blessed insurance finally agreed to cover after several appeals and pleas for help. ## Awesome! I am so happy that this medication is working so well for you. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, and constipation....

3 REPLIES

I was given 50 mg trintellix and seroquel 10 mg to take combined. They don't know if I'm manic depressive or just have major depressive disorder. Wondering what it might be supposed to do for me exactly. I recently lost my insurance and now I just have my prescription. ## These medications can be used to treat depression, anxiety, schizophrenia, and some cases of bipolar disorder. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, dry mouth, mood swings, and weight changes. How are you doing on them? ## The highest recommended dose for Trintellix by the manufacturer is 20 mgs. daily. Did a doctor actually prescribe you such a high dose of Trintellix? ## Yes my insurance will only pay for 20mgs of trintellix, so far the FDA has only approved...

3 REPLIES

I have been on Trintellix 20 mg for quite some time, my pshychiatrist started tapering me off gradually ,during this process i experience several symptoms that were listed but also noticed problems of paronoia and now that i have stopped taking trintellix the paronoia has sky rocketed as well as the anxiety and vomiting has anyone experienced a problem with paronoia while being TAPERED OFF of trintellix or once they completely STOPPED taking trintellix? ## That is possible, depending on how long you were taking it and how rapid the taper was, it might have been too fast for you. In many cases, stopping such a medication needs to be tapered very slowly, and occasionally, it must be adjusted according to how each individual reacts to the taper. The NIH also warns that stopping the medicat...

1 REPLY

I have been taking 10mg of Trintellix in the mornings for just under 3 weeks and it works well for me, but I can't sleep well and the lack of sleep alone is making me consider stopping this medication. Would it be better to take it at night? Is the sleep issue something that normally goes away? ## If the Trintellix is making you drowsy, it may be a good idea to try taking it at night, like you mentioned. Another issue is, were you already having difficulty sleeping before you started taking the Trintellix? If you were, it may not be the Trintellix. If you weren't, it probably is. You can also maybe lower it to 5 mgs for maybe 3 weeks, then jack it back up to 10 mgs if you feel you have to. That may help your body adjust to it. Good luck. ## Most medications in this class can cau...

7 REPLIES

My wife is prescribed Trintellix for depression. This is anti-depressant #3 in our effort to alleviate both anxiety and depression. She has a propensity for abusing benzos, but that is not an option now. We’re only on day 8, but she doesn’t appear to be making any progress. She has access to gabapentin and is finding that if she takes a large amount of this med (gabapentin), she can get temporary relief, experiencing some energy and mood enhancement. We’re talking about 2000mg to 3000mg at a time (once a day). Questions are: Is Gabapentin adversely masking any headway we might be making with Trintellix? Can Gabapentin, taken in these dosages, cause short-term and/or longterm negative effects for her? Obviously, we will run out of Gabapentin and this won’t be an o...

19 REPLIES

Like many of you, I struggled through finding the best anti-depressant for my journey. What I've learned is what may work well for you, may not have the same outcome with my body chemistry. SSRI's are most successful in treating my anxiety symptoms; however, the loss for words (brain fog) impacts my professional togetherness. I also experience bladder urgency, fatigue and passivity on them. I've also tried SNRI's with similar outcomes. Thus, whenever my doctor offered Trintellix, I openly gave it a try. Albeit, a lack of alleviation to my anxiety level, this is the first medication that doesn't promote brain fog or fatigue. I promise, I do not work for the company, I just wanted to foster hope. Keep trying if you haven't found your best one. Prayers to all! ## Th...

1 REPLY

I'm scared to start Trintellix. I have Major Depression. I get scared to start any new medicines but especially depression meds. My Dr gave me samples. I was also waiting to see if my insurance would cover it. (New insurance Oct. 1st) They said no unless I can produce dates and why others wouldn't work. That's impossible. I take Vyvanse and Klonopin. I've taken myself off depression medicines if they make me feel bad or weird. I can't take any that will make me gain weight. That just adds to the depression. After back surgery I only have 10 more lbs to lose. I can't do anything that I used to do because of back problems, so inactivity and not doing the things I love has made my depression worse. Other issues as well. I feel empty, things that used to make me shin...

3 REPLIES

Hi....I was given a 2 week sample of Trintellix to add to my Paxil 60mg. I'm one to do all the research that's possible & also one to read all the reviews available before starting a new medication when it comes to my mental health. I'm very hesitant after reading so many negative reviews with people complaining of severe nausea and stomach pain. I'm absolutely cannot handle vomiting.... I'd rather take a beating than to vomit. However, can I get some advice about this situation? Is it really worth the awful side effects? Should I also ask my doctor to prescribe me some antibiotics nausea medication to take along with the Trintellix? I certainly could use some advice on this. Thanks! ## There are quite a few typos in my original message I see. I did not mean to p...

9 REPLIES

I'm currently taking adapex & topamax for weight loss. Can I take trintellex also? I think I'm going through menopause & I'm not sleeping & having problems with speaking my mind... in your face. I know that adapex is an amphetamine... I've been on it before & had no problems with sleeping or anger. My Dr. prescribed trintellex... I'm not depressed either. ## Some of these medications can help with perimenopause or menopause symptoms. I take Prozac for mine and it helps tremendously. You do have to be cautious taking these together, since the Trintellix may increase the effects of the Adipex, so you should only take them together if they have all been prescribed for you and your doctor is monitoring you regularly. The FDA warns that you may also experi...

2 REPLIES

I've been on 20 mg for 7 months, working awesome but now I feel it's time to get off it. My choice would be to stop it cold turkey. Had anyone else done this yet, and how hard/easy was it? ## That's usually not a good idea after taking it for months, because according to the U.S. FDA, it could cause you to experience withdrawal effects, which may include nausea, diarrhea, headache, rebound depression, pain, and anxiety. A slow taper would be the best choice. Why do you want to stop it, if it is working so well for you? ## Hi, I just didn't want to be on pills anymore. Update, I did stop taking it CT, I did have the side effects they said, albeit reasonably mild and only a few days. My Dr wanted me back on it but it was up to me. I just started back on it at 10 mg but I...

2 REPLIES

Started 10 mg Trintellix 3 weeks ago. Vomiting at least 2x a day and constant nausea, fatigue, muscle and back pain. Trying to wean off it - doctor said take it every second day for a week then go see her. What is the normal time frame for withdrawal? I am terrified of this drug. I am diabetic and it is making my sugars wildly fluctuate too. ## Called Lundbeck (canadian office in Montreal) today to get advice on how to wean off/stop taking Trintellix. Shocked to be told "there is NO protocol for weaning/stopping this drug. You have to let your doctor decide how to proceed"! "Everyone has a different reaction". My doctor is away for a week so. My pharmacist and I are trying to figure something out, but I am absolutely stunned at Lundbeck's answer ## Hi Judy, Sorry to ...

26 REPLIES

Which is more apt to cause weight gain, Seroquel (400mg) or Trintellix (10mg)? ## Hi Heather, Because everyone's body reacts and responds differently to each and every medication, there is no way to know ahead of time how your body will respond. The only way to find out is to take each medication for a specific period of time through trial and error. However - NIH.gov does list "weight gain" specifically as a side effect of Seroquel; whilst they list nothing of that sort under Trintellix (vortioxetine). So if I had to guess, Seroquel may be more likely to cause weight gain based off this information alone. I hope this helps!

1 REPLY

I started Trintellix in December 2015. I did have nausea in the beginning but only short term. It worked pretty well for me-took it mainly for anxiety. I noticed I lost a couple pounds when I first started it but it seemed to normalize for the most part. At the first of this year I found out my insurance won't pay for it and the monthly cost is too much. I tapered off over about 10 days-was only on 5 mg. I have experienced multiple side effects, more than I bargained for-runny nose, fatigue, shortness of breath, feeling cold, bursts of irritability, decreased alcohol tolerance, and most disturbing: weight gain. I'm a small person-5,3", usually 112 pounds. But I am gaining 0.5-1 pound/week. Has anyone else experienced weight gain after stopping? The other side effects seem to...

4 REPLIES

I need to know if I will gain weight while taking the medicines, Trintellix & Klonopin, together? ## There is a chance that might, but it should not be a significant amount, it usually tops out around 10 pounds. The FDA warns that Klonopin carries the risk of being habit forming and may cause side effects, such as nausea, dizziness, headache, and irritability. Have you gained much weight? ## I take both and have actually lost weight. My appetite is reduced. ## Not if you’re lucky but I did. It came out of nowhere...bam, 20lbs in two weeks and extreme bloating. Stopped taking the trintellex almost a month ago and waiting patiently to see the weight come off but so far there has been no change and I’m miserable!

3 REPLIES

Hi everyone, Please can someone help me? 4 weeks ago I increased dosage of brintellix to 20mg (bc I started feeling very low again) after taking 10mg since December and finding improvement. After 4 weeks of still feeling low, I have suddenly started feeling nausea and general sickness. Is this normal after 4 weeks of increased dose? Thanks in advance. The gp I spoke to about increasing had not even heard of the med before so I doubt she would have been able to advise on side effects of increasing unfortunately.. here in uk it's still a relatively new drug. ## Yes, if you increase your dosage, it is normal to experience more side effects for awhile, they usually taper off, after about 4 to 5 weeks, according to NIH reports. You may also experience anxiety, and weight changes. Are you...

3 REPLIES

I have struggled with depression for most of my life, and am always in search of the perfect antidepressant. I work with a psych doctor who is always willing to try new things. 10 months ago I started 5 mg of Brintellix daily, within a week my mood was significantly elevated, I was sleeping better, waking up much earlier and was more motivated to do things in the morning. I went up to 10mg daily However the nausea was dreadful! I pushed through for a couple of weeks, changed to taking the brintellix at night and after a while it subsided. My mood got better and better, I had recently turned 50, and had gained a little weight, so with my new found morning energy I started working out 2times a week with a trainer, and then walking most other mornings! The walking then changed gradually to...

51 REPLIES

What My doctor has given me Vibryd 40 mg for anxiety 5 years ago. My anxiety level increased so she changed to trintellix 20 mg. I acutely stopped Taking vibryd and started taking trintellix. If I was to forget to take a vibryd I would have a severe itch all over especially on my face and head. I am having this same problem. Is this a withdrawal from vibryd? It has been 1 week since the change intreatment. ## These are both medications that are used to treat depression, anxiety, and panic attacks. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, dry mouth, and mood changes. How are you doing, now? Has there been any change? Itching could be a symptom of either one. Are you on any other medications?

1 REPLY

Hello, My husband has been depressed for almost 4 years. He can't sleep and and is angry all the time. He's had every test under the sun done but nothing is abnormal on a physical level. He sees a therapist who has prescribed him every type of medication out there and nothing has worked. He's been taking adderrall which works to a point but it does not help the anger. Fast forward to a month ago when he was prescribed Trintellix for the first time. We were both skeptical but it actually worked WONDERS. He was happy, motivated and taking control of his life again. I was over-the-moon because I felt like I finally got my husband back. Today he comes home from his parents in tears and tells me that the Trintellix stopped working. Now we are both so scared that things will go ba...

1 REPLY