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Cytisine

Cytisinicline, also known as baptitoxine, cytisine, or sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation.[1] Although widely used for smoking cessation in Eastern Europe, cytisinicline remains relatively unknown beyond it.[citation needed] However, it has been found effective in several randomized clinical trials, including some...

Capmatinib Hydrochloride

Capmatinib, sold under the brand name Tabrecta, is a medication for the treatment of adults with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to the exon 14 skipping of the MET gene, which codes for the membrane receptor HGFR, as detected by an FDA-approved test.[1][2][3] The most common adverse reactions are peripheral edema, nausea, fatigue, vomiting, dyspnea, and decreased appetite.[1]&...

Betamethasone Dipropionate + Calcipotriene Hydrate

Calcipotriol/betamethasone dipropionate, sold under the brand name Taclonex among others, is a fixed-dose combination medication of the synthetic vitamin D3 analog calcipotriol (also known as calcipotriene) and the synthetic corticosteroid betamethasone dipropionate for the treatment of plaque psoriasis.[3][4][5] It is used in the form of ointment, topical suspension, gel, aerosol, and foam.[2][3][4&#9...

Calcipotriene + Betamethasone Dipropionate

Calcipotriol/betamethasone dipropionate, sold under the brand name Taclonex among others, is a fixed-dose combination medication of the synthetic vitamin D3 analog calcipotriol (also known as calcipotriene) and the synthetic corticosteroid betamethasone dipropionate for the treatment of plaque psoriasis.[3][4][5] It is used in the form of ointment, topical suspension, gel, aerosol, and foam.[2][3][4&#9...

Drug Index

Tacrine is a centrally acting acetylcholinesterase inhibitor and indirect cholinergic agonist (parasympathomimetic). It was the first centrally acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Tacrine was first synthesised by Adrien Albert at the University of Sydney in 1949. It also acts as a histamine N-methyltransferase inhibitor.[1] Contents 1 Clinical use 2 Adverse Effects 2.1 Overdose 3 ...

Drug Index

Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disea...

Drug Index

Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.[5] It is a tablet taken by mouth.[5] Onset is typically within half an hour and the duration is up to 36 hours.[5] Common side effects include headache, muscle pain, flushed skin, and nausea.[5] Caution is advised in those with cardiovascular di...

Tadalafil

Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.[5] It is a tablet taken by mouth.[5] Onset is typically within half an hour and the duration is up to 36 hours.[5] Common side effects include headache, muscle pain, flushed skin, and nausea.[5] Caution is advised in those with cardiovascular di...

Drug Index

Tafamidis, sold under the brand names Vyndaqel and Vyndamax,[3] is a medication used to delay disease progression in adults with certain forms of transthyretin amyloidosis. It can be used to treat both hereditary forms, familial amyloid cardiomyopathy and familial amyloid polyneuropathy, as well as wild-type transthyretin amyloidosis, which formerly was called senile systemic amyloidosis. It works by stabilizing the quaternary structure of the protein transthyretin. In people ...

Drug Index

Tafasitamab, sold under the brand name Monjuvi, is a medication used in combination with lenalidomide for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).[1] Tafasitamab may cause serious side effects including infusion related reactions, bone marrow suppression, infections, and harm to an unborn baby.[2] The most common side effects of tafasitamab are low blood cell counts, fatigue, diarrhea, cough, fever, limb swellin...

Drug Index

Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria.[3] With respect to acute malaria, it is used together with other medications to prevent relapse by Plasmodium vivax.[3] It may be used to prevent all types of malaria.[3] It is taken by mouth.[4] Common side effects include vomiting, headache, and dizziness.[4] Other side effects may include methemo...

Dabrafenib Mesylate

Dabrafenib, sold under the brand name Tafinlar & Rafinlar[1] ( both by Novartis) among others, is a medication for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF (V600)-mutated metastatic melanoma.[...

Drug Index

Tafluprost (trade names Taflotan by Santen Pharmaceutical and Zioptan by Merck in the US) is a prostaglandin analogue. It is used topically (as eye drops) to control the progression of open-angle glaucoma and in the management of ocular hypertension, alone or in combination with other medication. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.[1][2] Contents 1 Adverse effects 2 Interactions 3 Pharmacology 3.1 Mechani...

Cimetidine

Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production.[1][7][8] It is mainly used in the treatment of heartburn and peptic ulcers.[1][8][9] The development of longer-acting H2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidine, decreased the use of cimetidine, and ...

Drug Index

Tagraxofusp, sold under the brand name Elzonris, is an anti-cancer medication for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN).[3][4] It was approved for use in the United States in 2018,[5] and after a second review, in the EU in January 2021.[2] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[6] Tagraxofusp is a fusion protein consisting of i...

Osimertinib

Osimertinib, sold under the brand name Tagrisso,[3] is a medication used to treat non-small-cell lung carcinomas with specific mutations.[4][5] It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor. The most common side effects include diarrhea, rash, musculoskeletal pain, dry skin, skin inflammation around nails, sore mouth, fatigue and cough.[6] Osimertinib was approved for medical use in the Unit...

Lanadelumab (shp643)

Lanadelumab (INN; trade name Takhzyro) is a human monoclonal antibody (class IgG1 kappa)[2] that targets plasma kallikrein (pKal)[3] in order to promote prevention of angioedema in patients with hereditary angioedema.[4][5] Lanadelumab, was approved in the United States as the first monoclonal antibody indicated for prophylactic treatment to prevent hereditary angioedema (HAE) attacks.[6][7] Takhzy...

Acetaminophen + Pentazocine

Paracetamol, also known as acetaminophen,[a] is a medication used to treat fever and mild to moderate pain.[11][12] At a standard dose, paracetamol only slightly decreases body temperature;[11][13][14] it is inferior to ibuprofen in that respect,[15] and the benefits of its use for fever are unclear.[11][16][17] Paracetamol may reliev...

Drug Index

Talazoparib, sold under the brand name Talzenna, is an orally available poly ADP ribose polymerase (PARP) inhibitor developed by Pfizer for the treatment of advanced breast cancer with germline BRCA mutations.[2] Talazoparib is similar to the first in class PARP inhibitor, olaparib.[3][4] It was approved in October 2018, in the United States and June 2019, in the European Union for germline BRCA-mutated, HER2-negative locally advanced or metasta...

Drug Index

Talc, or talcum, is a clay mineral, composed of hydrated magnesium silicate with the chemical formula Mg3Si4O10(OH)2. Talc in powdered form, often combined with corn starch, is used as baby powder. This mineral is used as a thickening agent and lubricant; is an ingredient in ceramics, paint, and roofing material; and is a main ingredient in many cosmetics.[5] It occurs as foliated to fibrous masses, and in an exceptionally rare crystal form. It has a perfect basal cleavage and...