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Drospirenone + Ethinyl Estradiol

Drospirenone is a progestin medication which is used in birth control pills to prevent pregnancy and in menopausal hormone therapy, among other uses.[1][7] It is available both alone under the brand name Slynd and in combination with an estrogen under the brand name Yasmin among others.[7][2] The medication is taken by mouth.[2][1] Common side effects include acne, headache, breast tenderness, weig...

Pegcetacoplan

Pegcetacoplan, sold under the brand name Empaveli among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH).[2][3][4][5] The most common side effects include injection-site reactions, infections, diarrhea, abdominal pain, respiratory tract infection, viral infection, and fatigue.[2][4] Paroxysmal nocturnal hemoglobinuria is characterized by red blood cell destruction, a...

Ethinyl Estradiol + Levonorgestrel

Extended or continuous cycle combined oral contraceptive pills are a packaging of combined oral contraceptive pills (COCPs) that reduce or eliminate the withdrawal bleeding that would occur once every 28 days in traditionally packaged COCPs. It works by reducing the frequency of the pill-free or placebo days. Extended cycle use of COCPs may also be called menstrual suppression,[2] although other hormonal medications or medication delivery systems (hormonal intrauterine devi...

Siltuximab

Siltuximab (INN, trade name Sylvant; also known as CNTO 328, anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6.[1][2] Siltuximab has been investigated for the treatment of neoplastic diseases:[3] metastatic renal cell cancer,[4] prostate cancer,[5] and Castleman's disease,[6][7] among ot...

Hyoscyamine

Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane (Hyoscyamus niger), mandrake (Mandragora officinarum), angel's trumpets (Brugmansia spp.), jimsonweed (Datura stramonium), tomato (Solanum lycopersicum), the sorcerers' tree (Latua pubiflora), and deadly nightshade (Atropa belladonna). It is the levorotary isomer of atropine (third of the t...

Budesonide/formoterol Fumarate Dihydrate

Budesonide/formoterol, sold under the brand name Symbicort among others, is a fixed-dose combination medication used in the management of asthma or chronic obstructive pulmonary disease (COPD).[2] It contains budesonide, a steroid and formoterol, a long-acting β2-agonist (LABA).[2] The product monograph does not support its use for sudden worsening or treatment of active bronchospasm.[2] However, a 2020 review of the literature does support...

Fluoxetine + Olanzapine

Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder as well as treatment-resistant depression.[1] Contents 1 Medical uses 2 Side effects 3 See also 4 References 5 External links Med...

Ivacaftor + Tezacaftor

Tezacaftor is a drug used for the treatment of cystic fibrosis (CF) in people six years and older, who have a F508del mutation, the most common type of mutation in the CFTR gene .[1][2] It is sold as a fixed-dose combination with ivacaftor under the brand name Symdeko.[3][4][5] It was approved by the U.S. FDA in 2018.[1] The combination of elexacaftor, tezacaftor, and ivacaftor is being sold as Tr...

Efavirenz + Lamivudine + Tenofovir Disoproxil Fumarate

Efavirenz (EFV), sold under the brand names Sustiva among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.[1] It is generally recommended for use with other antiretrovirals.[1] It may be used for prevention after a needlestick injury or other potential exposure.[1] It is sold both by itself and in combination as efavirenz/emtricitabine/tenofovir.[1] It is taken by mouth.[1] Common side e...

Epinephrine

Adrenaline, also known as epinephrine, is a hormone and medication[7][8] which is involved in regulating visceral functions (e.g., respiration).[7][9] Adrenaline is normally produced both by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart by acting on the SA node,[10] pu...

Pramlintide

Pramlintide (trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca).[1] Pramlintide is sold as an acetate salt. Contents 1 Pharmacology 2 Approval 3 Design and structure 4 References 5 External links Pharmacology Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β cells of the pancreas along ...

Amantadine

Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance.[5][6] It acts as a nicotinic antagonist, dopamine agonist, and noncompetitive NMDA antagonist.[7][8] The antiviral mechanism of action is antagonism of the influenzav...

Clobazam

Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968.[1] Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxioselective anxiolytic since 1970,[2][3] and an anticonvulsant since 1984.[4] The primary drug-development goal was to provide greater anxiolytic, anti-obsessive efficacy with fewer benzodiazep...

Naldemedine

Naldemedine (brand name Symproic in the US and Rizmoic in the European Union) is a medication that is used for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. It is a peripherally acting μ-opioid receptor antagonist and was developed by Shionogi.[1] Clinical studies have found it to possess statistically significant effectiveness for these indications and to be generally well tolerated, with predominantly mild to moderate gastrointesti...

Darunavir + Cobicistat + Emtricitabine + Tenofovir Alafenamide

Some of these combinations are complete single-tablet regimens; the others must be combined with additional pills to make a treatment regimen. Brand name(s) Ingredients (INN) Food and Drug Administration (FDA) approval date European Medicines Agency (EMA) approval date Health Canada approval date Company Single-tablet regimen? NRTIs / NtRTIs NNRTI INSTI PI PK enhancer Combivir lamivudinezidovudine September 26, 1997 ViiV Healthcare No Kaletra (developed coun...

Guaifenesin + Pseudoephedrine

Guaifenesin, sold under the brand name Mucinex, among others,[3] is a medication used as an expectorant, intended to help cough out phlegm from the airways.[3] Chemically it is an ether of guaiacol and glycerine. It is unclear if it decreases coughing.[3] Use is not recommended in children less than 6 years old.[4] It is often used in combination with other medications.[3] It is taken by mouth.[3] ...

Dextromethorphan + Guaifenesin + Pseudoephedrine

Benylin is a brand name owned by Johnson & Johnson for a range of cough, cold and flu medications. Some Benylin products also contain codeine, which is used to treat pain, cough and diarrhea. The flagship cough syrup and cold care brand is marketed in several countries as Benylin DM, for its active ingredient, dextromethorphan. However, the range of products available in both solid dosage and liquid forms have formulations with multiple ingredients including pseudoephedrine, paracetamol (...

Palivizumab

Palivizumab, sold under the brand name Synagis, is a monoclonal antibody produced by recombinant DNA technology used to prevent severe disease caused by respiratory syncytial virus (RSV) infections.[4][3] It is recommended for infants at high-risk for RSV due to conditions such as prematurity or other medical problems including heart or lung diseases.[4][3] The most common side effects include fever and rash.[4]&a...

Fluocinolone

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching.[citation needed] It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.[1] Preparations containing it were first marketed under the name Synalar. A typical do...

Aspirin, ASA + Caffeine + Dihydrocodeine

Dihydrocodeine is a semi-synthetic opioid analgesic prescribed for pain or severe dyspnea, or as an antitussive, either alone or compounded with paracetamol (acetaminophen) (as in co-dydramol) or aspirin. It was developed in Germany in 1908 and first marketed in 1911.[3] Commonly available as tablets, solutions, elixirs, and other oral forms, dihydrocodeine is also available in some countries as an injectable solution for deep subcutaneous and intra-muscular administration. As...